ID   Q0ZCI4_HUMAN            Unreviewed;       125 AA.
AC   Q0ZCI4;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=Immunglobulin heavy chain variable region {ECO:0000313|EMBL:ABG38434.1};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ABG38434.1};
RN   [1] {ECO:0000313|EMBL:ABG38434.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=EM2-CON-14-VH3-93 {ECO:0000313|EMBL:ABG38434.1};
RX   PubMed=16860443; DOI=10.1016/j.vaccine.2006.06.045;
RA   Shriner A.K., Smithson S.L., Prinz D.M., Rabquer B., Khuder S., Goomber R.,
RA   Westerink M.A.J.;
RT   "Comparison of the human immune response to conjugate and polysaccharide
RT   pneumococcal vaccination using a reconstituted SCID mouse model.";
RL   Vaccine 24:7197-7203(2006).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004370}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}.
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DR   EMBL; DQ535070; ABG38434.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0ZCI4; -.
DR   PeptideAtlas; Q0ZCI4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   CDD; cd04981; IgV_H; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   PANTHER; PTHR23266; IMMUNOGLOBULIN HEAVY CHAIN; 1.
DR   PANTHER; PTHR23266:SF241; IMMUNOGLOBULIN HEAVY VARIABLE 3-30-RELATED; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   4: Predicted;
KW   Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Immunoglobulin {ECO:0000256|ARBA:ARBA00043265};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136}.
FT   DOMAIN          1..97
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ABG38434.1"
FT   NON_TER         125
FT                   /evidence="ECO:0000313|EMBL:ABG38434.1"
SQ   SEQUENCE   125 AA;  13599 MW;  A2210B82F8E9FB9A CRC64;
     PLVQLVESGG GVVQPGRSLR LSCAASGFTF SSYGMHWVRQ APGKGLEWVA VISYDGSNKY
     YADSVKGRFT ISRDNSKNTL YLQMNSLRAE DTAVYYCAKD QRGIVAVPAA TFDYWGQGTL
     VTVSS
//