ID Q0ZND2_9TELE Unreviewed; 215 AA.
AC Q0ZND2;
DT 22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT 22-AUG-2006, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Insulin-like growth factor 2 {ECO:0000313|EMBL:ABC60229.1};
GN Name=IGF2 {ECO:0000313|EMBL:ABC60229.1};
OS Ilyodon sp. 'Ameca'.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Goodeidae; Ilyodon.
OX NCBI_TaxID=208462 {ECO:0000313|EMBL:ABC60229.1};
RN [1] {ECO:0000313|EMBL:ABC60229.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17636118; DOI=10.1073/pnas.0705048104;
RA O'Neill M.J., Lawton B.R., Mateos M., Carone D.M., Ferreri G.C., Hrbek T.,
RA Meredith R.W., Reznick D.N., O'Neill R.J.;
RT "Ancient and continuing Darwinian selection on insulin-like growth factor
RT II in placental fishes.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:12404-12409(2007).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR EMBL; DQ337453; ABC60229.1; -; mRNA.
DR AlphaFoldDB; Q0ZND2; -.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd04368; IlGF; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR022334; IGF2.
DR InterPro; IPR013576; IGF2_C.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR022350; Insulin-like_growth_factor.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR46886; INSULIN-LIKE GROWTH FACTOR II; 1.
DR PANTHER; PTHR46886:SF1; INSULIN-LIKE GROWTH FACTOR II; 1.
DR Pfam; PF08365; IGF2_C; 1.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR02002; INSLNLIKEGF.
DR PRINTS; PR02006; INSLNLIKEGF2.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR622350-50};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406}.
FT DOMAIN 53..110
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
FT REGION 120..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 56..97
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 68..110
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 96..101
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
SQ SEQUENCE 215 AA; 24497 MW; AF9C88E6B427EE8E CRC64;
METQQRSGHH SLCHTCRTTE SCRMKVKKMC TTSRALLFAL TLTLYVVEMA SAETLCGGEL
VDALQFVCED RGFYFSRPTS RGNNRRIQTR GIVEECCFRS CDLNLLEQYC AKPAKSERDV
SSSSIQGTPV MPTPKQEVSR KPHVPIKYPT YETWQKKAAQ RLRRGIPAIL RAKKFRRQAQ
KMKAQEQAVI HRPLISLPSK LPAVLHTTDN FVSHK
//
