ID Q124J4_POLSJ Unreviewed; 312 AA.
AC Q124J4;
DT 22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT 22-AUG-2006, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein {ECO:0000313|EMBL:ABE46048.1};
GN OrderedLocusNames=Bpro_4156 {ECO:0000313|EMBL:ABE46048.1};
OS Polaromonas sp. (strain JS666 / ATCC BAA-500).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Polaromonas.
OX NCBI_TaxID=296591 {ECO:0000313|EMBL:ABE46048.1, ECO:0000313|Proteomes:UP000001983};
RN [1] {ECO:0000313|Proteomes:UP000001983}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JS666 / ATCC BAA-500 {ECO:0000313|Proteomes:UP000001983};
RX PubMed=18723656; DOI=10.1128/AEM.00197-08;
RA Mattes T.E., Alexander A.K., Richardson P.M., Munk A.C., Han C.S.,
RA Stothard P., Coleman N.V.;
RT "The genome of Polaromonas sp. strain JS666: insights into the evolution of
RT a hydrocarbon- and xenobiotic-degrading bacterium, and features of
RT relevance to biotechnology.";
RL Appl. Environ. Microbiol. 74:6405-6416(2008).
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DR EMBL; CP000316; ABE46048.1; -; Genomic_DNA.
DR AlphaFoldDB; Q124J4; -.
DR STRING; 296591.Bpro_4156; -.
DR KEGG; pol:Bpro_4156; -.
DR eggNOG; COG0111; Bacteria.
DR HOGENOM; CLU_019796_1_0_4; -.
DR Proteomes; UP000001983; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:UniProt.
DR CDD; cd12164; GDH_like_2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43333; 2-HACID_DH_C DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43333:SF1; 2-HACID_DH_C DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001983}.
FT DOMAIN 103..273
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 312 AA; 33959 MW; 8A1A7F051ABBCDC4 CRC64;
MNPMRISFCC TDTKAQPWLE GLRAALPDSQ VELWSAGAAL ADYAVVWAPP QQFLDEQTRL
KGIFNIGAGV DALMKLRLPA GIPVVRLDDA GMSVQMAEYV CHAVIRHFRE FDGYEADAAQ
GKWSYRKTRL RKDFPVGVMG LGVLGERVGQ ALAQFDFPVM GWSRSAKNVA GMQCFAGEAG
FPEFLAATRI LVCLLPLTPD TEGIMRRDTL ARLQPGAYVI NVARGGHLVD EDLIALIDSG
HIAGAMLDVF RTEPLPASHP FWAHPRITVT PHTSARTLRE ESIAQIAGKI RALHSGTPIA
SLAGVVDPKK GY
//
