GenomeNet

Database: UniProt
Entry: Q12C71_POLSJ
LinkDB: Q12C71_POLSJ
Original site: Q12C71_POLSJ 
ID   Q12C71_POLSJ            Unreviewed;       535 AA.
AC   Q12C71;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   24-JAN-2024, entry version 91.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   OrderedLocusNames=Bpro_1940 {ECO:0000313|EMBL:ABE43871.1};
OS   Polaromonas sp. (strain JS666 / ATCC BAA-500).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Polaromonas.
OX   NCBI_TaxID=296591 {ECO:0000313|EMBL:ABE43871.1, ECO:0000313|Proteomes:UP000001983};
RN   [1] {ECO:0000313|Proteomes:UP000001983}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JS666 / ATCC BAA-500 {ECO:0000313|Proteomes:UP000001983};
RX   PubMed=18723656; DOI=10.1128/AEM.00197-08;
RA   Mattes T.E., Alexander A.K., Richardson P.M., Munk A.C., Han C.S.,
RA   Stothard P., Coleman N.V.;
RT   "The genome of Polaromonas sp. strain JS666: insights into the evolution of
RT   a hydrocarbon- and xenobiotic-degrading bacterium, and features of
RT   relevance to biotechnology.";
RL   Appl. Environ. Microbiol. 74:6405-6416(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000316; ABE43871.1; -; Genomic_DNA.
DR   RefSeq; WP_011482870.1; NC_007948.1.
DR   AlphaFoldDB; Q12C71; -.
DR   STRING; 296591.Bpro_1940; -.
DR   REBASE; 12115; M.PspJORF1940P.
DR   KEGG; pol:Bpro_1940; -.
DR   eggNOG; COG0286; Bacteria.
DR   HOGENOM; CLU_013049_4_1_4; -.
DR   OMA; NSADWAW; -.
DR   OrthoDB; 9784823at2; -.
DR   Proteomes; UP000001983; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1260.30; -; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR022749; D12N6_MeTrfase_N.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR038333; T1MK-like_N_sf.
DR   PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR   PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR   Pfam; PF12161; HsdM_N; 1.
DR   Pfam; PF02384; N6_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000313|EMBL:ABE43871.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001983};
KW   Transferase {ECO:0000313|EMBL:ABE43871.1}.
FT   DOMAIN          5..148
FT                   /note="N6 adenine-specific DNA methyltransferase N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12161"
FT   DOMAIN          161..494
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
SQ   SEQUENCE   535 AA;  59042 MW;  6A64E3C20F270BDA CRC64;
     MLDDIKKTLW ATADKLRANM DAAEYKHLVL GLIFVKYISD TFAARRSEVA TRLADPKDEY
     FFEGATPKTL AVELEDRDYY KSVNVFWVPE AARWESLRAA AKQPDIGKRI DEALTLVEVE
     NPKLKGILDK RYARAQLPDG KLGELVDLIS TVGFGDNPSV ARDILGQVYE YFLGMFASAE
     GKRGGQFYTP ASIVKTLVAV LNPHSGKVYD PCCGSGGMFV QSEKFIEAHG GKLGDASIYG
     QEANPTTWRL AAMNLAIRGI DFNLGREPAD TFVRNQHPDL RADFILANPP FNISDWWHAS
     LTGDARWQYG DPPTGNANYA WLQHMLHHLK PTGRAGIVLA NGSMSSSQNS EGQIRAAMVE
     ADVVEVMIAL PGQLFFNTQI PACLWFLVKK KTRRQGEVLF IDARKLATMI SRVQSEFTDE
     VIARIANTVA AWRGESLPLP LGLGEGEGEG EGSPAPAPYA DIPGFCRSVK LKEIAQHGHV
     LTPGRYVGAE EVEDNDEDFA TKMQQLTEKL GEQMAKGAEL DQLIRQKLGG LGYEF
//
DBGET integrated database retrieval system