ID   Q12GR9_POLSJ            Unreviewed;       637 AA.
AC   Q12GR9;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   SubName: Full=Diguanylate cyclase/phosphodiesterase {ECO:0000313|EMBL:ABE42273.1};
GN   OrderedLocusNames=Bpro_0308 {ECO:0000313|EMBL:ABE42273.1};
OS   Polaromonas sp. (strain JS666 / ATCC BAA-500).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Polaromonas.
OX   NCBI_TaxID=296591 {ECO:0000313|EMBL:ABE42273.1, ECO:0000313|Proteomes:UP000001983};
RN   [1] {ECO:0000313|Proteomes:UP000001983}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JS666 / ATCC BAA-500 {ECO:0000313|Proteomes:UP000001983};
RX   PubMed=18723656; DOI=10.1128/AEM.00197-08;
RA   Mattes T.E., Alexander A.K., Richardson P.M., Munk A.C., Han C.S.,
RA   Stothard P., Coleman N.V.;
RT   "The genome of Polaromonas sp. strain JS666: insights into the evolution of
RT   a hydrocarbon- and xenobiotic-degrading bacterium, and features of
RT   relevance to biotechnology.";
RL   Appl. Environ. Microbiol. 74:6405-6416(2008).
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DR   EMBL; CP000316; ABE42273.1; -; Genomic_DNA.
DR   RefSeq; WP_011481280.1; NC_007948.1.
DR   AlphaFoldDB; Q12GR9; -.
DR   STRING; 296591.Bpro_0308; -.
DR   KEGG; pol:Bpro_0308; -.
DR   eggNOG; COG5001; Bacteria.
DR   HOGENOM; CLU_000445_109_2_4; -.
DR   OrthoDB; 5894408at2; -.
DR   Proteomes; UP000001983; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   CDD; cd06225; HAMP; 1.
DR   Gene3D; 3.30.110.200; -; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   Gene3D; 6.20.270.20; LapD/MoxY periplasmic domain; 1.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR032244; LapD_MoxY_N.
DR   InterPro; IPR042461; LapD_MoxY_peri_C.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   PANTHER; PTHR33121:SF32; RNASE E SPECIFICITY FACTOR CSRD; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF16448; LapD_MoxY_N; 1.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001983};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        150..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          170..221
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          263..395
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          404..637
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
FT   REGION          383..403
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   637 AA;  69901 MW;  968508AB057CD45C CRC64;
     MSLIKQLWIA IIVVMTIAFG GSMVVSVLSA RHYLEQQLQV KNIDNATALA LSLSQLPKDP
     VTVELQVATQ FDAGHYRFIR IVSPTGQTVV ERVFTGQLQG APAWFARLIP IRAVPGQALI
     QDGWKQYGTL TLASHEQYVY KSLWDGTLEL LLWFVLGSVI TGIAGTLAIR FITRPLGDVV
     GQAEAIAERR FLRIAEPRTP ELRSVVRAMN SMVERLKALF SEEAARLEAL RQKVNLDALT
     GLSGREHFLS QLRELLVGED SGAEGVLVML RVNDLNMLNA RLGHQRADTL LQQLGGVLKD
     SMREHSGQQA GRLKGGDFAL ACPGITSPAQ AASELHQRLN QAWLPNWVAE VPDLFHLAAV
     PYQRAESIGD LLSRADEALA RAEAEGPNSW HASEADSGST ARPAEQWRSL LTEAVASGKL
     RLAFYRVVGS GSQNAIHQEG VIRLQIDDTG TLLPARDFMP MAAHLNLSAP IDLEVVRLAI
     AHLRTTPGDI AVNLSAETIA DFSFRYELRM LLEFHPEICK RLLFEVPEQG VFKQFNAFRD
     LVLTLKPLGC RVGIEYFGQR FAEGDKLADL GLDYIKVHPS YVRDIAHNPG NQEFLKGLCK
     VARNFGIVVI ALGVESDSDL PLLASLGFDG VTGPGVK
//