ID Q12MB1_SHEDO Unreviewed; 356 AA.
AC Q12MB1;
DT 22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT 22-AUG-2006, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Iron-containing alcohol dehydrogenase {ECO:0000313|EMBL:ABE55415.1};
GN OrderedLocusNames=Sden_2133 {ECO:0000313|EMBL:ABE55415.1};
OS Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Shewanellaceae; Shewanella.
OX NCBI_TaxID=318161 {ECO:0000313|EMBL:ABE55415.1, ECO:0000313|Proteomes:UP000001982};
RN [1] {ECO:0000313|EMBL:ABE55415.1, ECO:0000313|Proteomes:UP000001982}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OS217 / ATCC BAA-1090 / DSM 15013
RC {ECO:0000313|Proteomes:UP000001982};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P.;
RT "Complete sequence of Shewanella denitrificans OS217.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0007829|PDB:3RF7}
RP X-RAY CRYSTALLOGRAPHY (2.12 ANGSTROMS) IN COMPLEX WITH IRON AND NAD.
RG Joint Center for Structural Genomics (JCSG);
RT "Crystal structure of an Iron-containing alcohol dehydrogenase (Sden_2133)
RT from Shewanella denitrificans OS-217 at 2.12 A resolution.";
RL Submitted (APR-2011) to the PDB data bank.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000302; ABE55415.1; -; Genomic_DNA.
DR RefSeq; WP_011496570.1; NC_007954.1.
DR PDB; 3RF7; X-ray; 2.12 A; A=1-356.
DR PDBsum; 3RF7; -.
DR AlphaFoldDB; Q12MB1; -.
DR SMR; Q12MB1; -.
DR STRING; 318161.Sden_2133; -.
DR DNASU; 4018625; -.
DR KEGG; sdn:Sden_2133; -.
DR eggNOG; COG1454; Bacteria.
DR HOGENOM; CLU_773153_0_0_6; -.
DR OrthoDB; 9815791at2; -.
DR Proteomes; UP000001982; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd08184; Fe-ADH_KdnB-like; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR001670; ADH_Fe/GldA.
DR InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR PANTHER; PTHR11496:SF104; 3-DEOXY-ALPHA-D-MANNO-OCTULOSONATE 8-OXIDASE; 1.
DR PANTHER; PTHR11496; ALCOHOL DEHYDROGENASE; 1.
DR Pfam; PF00465; Fe-ADH; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3RF7}; Calcium {ECO:0007829|PDB:3RF7};
KW Metal-binding {ECO:0007829|PDB:3RF7};
KW Nucleotide-binding {ECO:0007829|PDB:3RF7};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001982}.
FT DOMAIN 11..327
FT /note="Alcohol dehydrogenase iron-type/glycerol
FT dehydrogenase GldA"
FT /evidence="ECO:0000259|Pfam:PF00465"
FT BINDING 42
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0007829|PDB:3RF7"
FT BINDING 68
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0007829|PDB:3RF7"
FT BINDING 100
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0007829|PDB:3RF7"
FT BINDING 101
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0007829|PDB:3RF7"
FT BINDING 104
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0007829|PDB:3RF7"
FT BINDING 140
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0007829|PDB:3RF7"
FT BINDING 149
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0007829|PDB:3RF7"
FT BINDING 151
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0007829|PDB:3RF7"
FT BINDING 160
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0007829|PDB:3RF7"
FT BINDING 179
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0007829|PDB:3RF7"
FT BINDING 191
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0007829|PDB:3RF7"
FT BINDING 194
FT /ligand="Fe(3+)"
FT /ligand_id="ChEBI:CHEBI:29034"
FT /evidence="ECO:0007829|PDB:3RF7"
FT BINDING 198
FT /ligand="Fe(3+)"
FT /ligand_id="ChEBI:CHEBI:29034"
FT /evidence="ECO:0007829|PDB:3RF7"
FT BINDING 258
FT /ligand="Fe(3+)"
FT /ligand_id="ChEBI:CHEBI:29034"
FT /evidence="ECO:0007829|PDB:3RF7"
FT BINDING 272
FT /ligand="Fe(3+)"
FT /ligand_id="ChEBI:CHEBI:29034"
FT /evidence="ECO:0007829|PDB:3RF7"
SQ SEQUENCE 356 AA; 39477 MW; 78EB407D9123AD49 CRC64;
MSFKNFKCVP KMIFGRGSFV QLDTVLEQER TDANDFVVFL VDDVHQHKPL AARVPNKAHD
LVIYVNVDDE PTTVQVDELT AQVKAFNTKL PVSVVGLGGG STMDLAKAVS LMLTNPGSSS
EYQGWDLIKN PAVHHIGIPT VSGTGAEASR TAVLCGPVRK LGLNSDYTVF DQIIMDSELI
AGVPTDQWFY TGMDCFIHCV ESLQGTYLNE FAKAFAEKSM DLCREVYLDD HPEKDDKLMM
ASYMGGMSIA YSQVGACHAV SYGLGYVLGY HHGIGNCLAF DVLEEFYPEG VAEFRKMMEI
HNITLPKNIC KDLPDETIAK MVAVTKSMGP LWDNVYGKGW EEKVTDEMLT KLFRRI
//
