ID   Q12UV7_METBU            Unreviewed;       291 AA.
AC   Q12UV7;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   SubName: Full=Cystathionine-beta-synthase and DUF293 domains-containing protein {ECO:0000313|EMBL:ABE52769.1};
GN   OrderedLocusNames=Mbur_1886 {ECO:0000313|EMBL:ABE52769.1};
OS   Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 /
OS   ACE-M).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanococcoides.
OX   NCBI_TaxID=259564 {ECO:0000313|EMBL:ABE52769.1, ECO:0000313|Proteomes:UP000001979};
RN   [1] {ECO:0000313|Proteomes:UP000001979}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 6242 / NBRC 107633 / OCM 468 / ACE-M
RC   {ECO:0000313|Proteomes:UP000001979};
RX   PubMed=19404327; DOI=10.1038/ismej.2009.45;
RA   Allen M.A., Lauro F.M., Williams T.J., Burg D., Siddiqui K.S.,
RA   De Francisci D., Chong K.W., Pilak O., Chew H.H., De Maere M.Z., Ting L.,
RA   Katrib M., Ng C., Sowers K.R., Galperin M.Y., Anderson I.J., Ivanova N.,
RA   Dalin E., Martinez M., Lapidus A., Hauser L., Land M., Thomas T.,
RA   Cavicchioli R.;
RT   "The genome sequence of the psychrophilic archaeon, Methanococcoides
RT   burtonii: the role of genome evolution in cold adaptation.";
RL   ISME J. 3:1012-1035(2009).
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DR   EMBL; CP000300; ABE52769.1; -; Genomic_DNA.
DR   RefSeq; WP_011499912.1; NC_007955.1.
DR   AlphaFoldDB; Q12UV7; -.
DR   STRING; 259564.Mbur_1886; -.
DR   GeneID; 3997678; -.
DR   KEGG; mbu:Mbur_1886; -.
DR   HOGENOM; CLU_926289_0_0_2; -.
DR   OrthoDB; 64432at2157; -.
DR   Proteomes; UP000001979; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd04588; CBS_pair_archHTH_assoc; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR016436; UCP005063_CBS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   PANTHER; PTHR48108; CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR48108:SF26; CBS DOMAIN-CONTAINING PROTEIN MJ0729; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005063; UCP005063_CBS_MJ1232; 1.
DR   SMART; SM00116; CBS; 2.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51371; CBS; 2.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW   CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW   ProRule:PRU00703}; Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167}.
FT   DOMAIN          177..233
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   DOMAIN          239..291
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   291 AA;  31872 MW;  5D9390C865F676F9 CRC64;
     MELTPIQKEI IIELINLQRQ KASAVKGEEI AELIDRNPGT VRNQMQSLKM LGLVEGVPGP
     KGGYRATGDA YEALNVTAMD KEAEVPIYKN ETIVNGATVA EISFTTVRHP DLCNGRIKVL
     GNIKAFNSGD RVQVGPTPVN RLIVRGEVVG RDDTENSLLF TITEMVSLPK KSVKHYIKKD
     TISVEPNYTI QEAARIFITN KIHGAPVEDN GKIVGMVTFM DIGETLASGK MTLKIKDIMT
     KNVITIDGDS SLSDAVHLFN EHNIGRLIVT IDGIPRGMIS KTDVLHELVI C
//