ID TYSY_METBU Reviewed; 217 AA.
AC Q12X17;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Putative thymidylate synthase {ECO:0000255|HAMAP-Rule:MF_01686};
DE Short=TS {ECO:0000255|HAMAP-Rule:MF_01686};
DE Short=TSase {ECO:0000255|HAMAP-Rule:MF_01686};
DE EC=2.1.1.- {ECO:0000255|HAMAP-Rule:MF_01686};
GN Name=thyA {ECO:0000255|HAMAP-Rule:MF_01686}; OrderedLocusNames=Mbur_1079;
OS Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 /
OS ACE-M).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanococcoides.
OX NCBI_TaxID=259564;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6242 / NBRC 107633 / OCM 468 / ACE-M;
RX PubMed=19404327; DOI=10.1038/ismej.2009.45;
RA Allen M.A., Lauro F.M., Williams T.J., Burg D., Siddiqui K.S.,
RA De Francisci D., Chong K.W., Pilak O., Chew H.H., De Maere M.Z., Ting L.,
RA Katrib M., Ng C., Sowers K.R., Galperin M.Y., Anderson I.J., Ivanova N.,
RA Dalin E., Martinez M., Lapidus A., Hauser L., Land M., Thomas T.,
RA Cavicchioli R.;
RT "The genome sequence of the psychrophilic archaeon, Methanococcoides
RT burtonii: the role of genome evolution in cold adaptation.";
RL ISME J. 3:1012-1035(2009).
CC -!- FUNCTION: May catalyze the biosynthesis of dTMP using an unknown
CC cosubstrate. {ECO:0000255|HAMAP-Rule:MF_01686}.
CC -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis. {ECO:0000255|HAMAP-
CC Rule:MF_01686}.
CC -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_01686}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01686}.
CC -!- SIMILARITY: Belongs to the thymidylate synthase family. Archaeal-type
CC ThyA subfamily. {ECO:0000255|HAMAP-Rule:MF_01686}.
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DR EMBL; CP000300; ABE52009.1; -; Genomic_DNA.
DR RefSeq; WP_011499157.1; NC_007955.1.
DR AlphaFoldDB; Q12X17; -.
DR SMR; Q12X17; -.
DR STRING; 259564.Mbur_1079; -.
DR GeneID; 3998016; -.
DR KEGG; mbu:Mbur_1079; -.
DR HOGENOM; CLU_084975_0_0_2; -.
DR OrthoDB; 50118at2157; -.
DR UniPathway; UPA00575; -.
DR Proteomes; UP000001979; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR HAMAP; MF_01686; Thymidy_synth_arch; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR014620; Thymidylate_synthase_arc.
DR NCBIfam; TIGR03283; thy_syn_methano; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR PANTHER; PTHR11548:SF1; THYMIDYLATE SYNTHASE-RELATED; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PIRSF; PIRSF036752; TSase_MJ051; 1.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Methyltransferase; Nucleotide biosynthesis; Transferase.
FT CHAIN 1..217
FT /note="Putative thymidylate synthase"
FT /id="PRO_1000000626"
FT ACT_SITE 139
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01686"
SQ SEQUENCE 217 AA; 24953 MW; 66DBEF456C5BFD54 CRC64;
MTHDAAIGRL IKARTISDAW YRGLNVIWNH GSLITDERGS QIREFMNLMV VIEDPYSNEI
PEDSAWNHER LEEYAKQLIT GENAQDFEYT YGQRLRNWDG KVDQIEYVIE KLTNNKTTRR
ATAVTWVPTI DTKVDEVPCM IIDDFKIRDD TVHLTTLFRS HDFAGAYPAN LYGLSKLLEY
VADKVGLAPG TITTMSVSAH IYDHDWDKIE KIIKGVQ
//
