ID ZN211_HUMAN Reviewed; 564 AA.
AC Q13398; B4DH10; B4DLC9; B4E3C9; B9ZVS7; B9ZVW1; Q05BQ7; Q2TAL7;
AC Q59EG4; Q59G36; Q5EBL6;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 29-MAY-2013, entry version 114.
DE RecName: Full=Zinc finger protein 211;
DE AltName: Full=Zinc finger protein C2H2-25;
GN Name=ZNF211;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 5; 6 AND 7).
RC TISSUE=Blood, Brain, Hepatoma, Tongue, and Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), AND VARIANT
RP VAL-314.
RC TISSUE=Brain, and Endothelial cell;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA Ohara O., Nagase T., Kikuno R.F.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 1-505 (ISOFORM 1), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 24-564 (ISOFORM 1), AND VARIANT VAL-314.
RC TISSUE=Chondrosarcoma, Skin, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 160-564 (ISOFORMS 1/2/3/4/5/6).
RC TISSUE=Brain;
RX PubMed=9096115; DOI=10.1007/s003359900414;
RA Becker K.G., Canning R.D., Nagle J.W., Dehejia A.M.,
RA Polymeropoulos M.H., Lee I.J., Gado A.M., Biddison W.E., Drew P.D.;
RT "Molecular cloning and mapping of a novel developmentally regulated
RT human C2H2-type zinc finger.";
RL Mamm. Genome 8:287-289(1997).
RN [6]
RP PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hippocampus;
RX PubMed=7633419; DOI=10.1093/hmg/4.4.685;
RA Becker K.G., Nagle J.W., Canning R.D., Biddison W.E., Ozato K.,
RA Drew P.D.;
RT "Rapid isolation and characterization of 118 novel C2H2-type zinc
RT finger cDNAs expressed in human brain.";
RL Hum. Mol. Genet. 4:685-691(1995).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=7;
CC Name=1;
CC IsoId=Q13398-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q13398-2; Sequence=VSP_035702;
CC Name=3;
CC IsoId=Q13398-3; Sequence=VSP_035704;
CC Name=4;
CC IsoId=Q13398-4; Sequence=VSP_035705;
CC Note=No experimental confirmation available;
CC Name=5;
CC IsoId=Q13398-5; Sequence=VSP_035703;
CC Name=6;
CC IsoId=Q13398-6; Sequence=VSP_035706;
CC Name=7;
CC IsoId=Q13398-7; Sequence=VSP_045643;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family.
CC -!- SIMILARITY: Contains 12 C2H2-type zinc fingers.
CC -!- SIMILARITY: Contains 1 KRAB domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA93261.1; Type=Erroneous initiation;
CC Sequence=AAH34351.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
CC Sequence=BAD93084.1; Type=Erroneous initiation;
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DR EMBL; AK026941; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK294869; BAG57971.1; -; mRNA.
DR EMBL; AK296942; BAG59491.1; -; mRNA.
DR EMBL; AK297047; BAG59573.1; -; mRNA.
DR EMBL; AK304666; BAG65441.1; -; mRNA.
DR EMBL; AB209273; BAD92510.1; -; mRNA.
DR EMBL; AB209847; BAD93084.1; ALT_INIT; mRNA.
DR EMBL; AC003682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC034351; AAH34351.1; ALT_SEQ; mRNA.
DR EMBL; BC089440; AAH89440.1; -; mRNA.
DR EMBL; BC110856; AAI10857.1; -; mRNA.
DR EMBL; U38904; AAA93261.1; ALT_INIT; mRNA.
DR IPI; IPI00012868; -.
DR IPI; IPI00394844; -.
DR IPI; IPI00419492; -.
DR IPI; IPI00746528; -.
DR IPI; IPI00883583; -.
DR IPI; IPI00914861; -.
DR IPI; IPI00915004; -.
DR RefSeq; NP_001252526.1; NM_001265597.1.
DR RefSeq; NP_001252527.1; NM_001265598.1.
DR RefSeq; NP_001252528.1; NM_001265599.1.
DR RefSeq; NP_001252529.1; NM_001265600.1.
DR RefSeq; NP_006376.2; NM_006385.3.
DR RefSeq; NP_942152.1; NM_198855.2.
DR UniGene; Hs.590977; -.
DR ProteinModelPortal; Q13398; -.
DR IntAct; Q13398; 1.
DR PhosphoSite; Q13398; -.
DR DMDM; 215273921; -.
DR PaxDb; Q13398; -.
DR PRIDE; Q13398; -.
DR Ensembl; ENST00000240731; ENSP00000240731; ENSG00000121417.
DR Ensembl; ENST00000254182; ENSP00000254182; ENSG00000121417.
DR Ensembl; ENST00000347302; ENSP00000339562; ENSG00000121417.
DR Ensembl; ENST00000391703; ENSP00000375584; ENSG00000121417.
DR Ensembl; ENST00000420680; ENSP00000399193; ENSG00000121417.
DR Ensembl; ENST00000541801; ENSP00000442601; ENSG00000121417.
DR Ensembl; ENST00000544273; ENSP00000441386; ENSG00000121417.
DR GeneID; 10520; -.
DR KEGG; hsa:10520; -.
DR UCSC; uc002qpp.2; human.
DR UCSC; uc002qpq.2; human.
DR UCSC; uc002qpt.2; human.
DR UCSC; uc010yhb.1; human.
DR UCSC; uc010yhe.1; human.
DR CTD; 10520; -.
DR GeneCards; GC19P058141; -.
DR HGNC; HGNC:13003; ZNF211.
DR HPA; HPA011340; -.
DR MIM; 601856; gene.
DR neXtProt; NX_Q13398; -.
DR PharmGKB; PA37582; -.
DR eggNOG; COG5048; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q13398; -.
DR KO; K09228; -.
DR Reactome; REACT_71; Gene Expression.
DR GenomeRNAi; 10520; -.
DR NextBio; 39896; -.
DR ArrayExpress; Q13398; -.
DR Bgee; Q13398; -.
DR Genevestigator; Q13398; -.
DR GermOnline; ENSG00000121417; Homo sapiens.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; -; 12.
DR InterPro; IPR001909; Krueppel-associated_box.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF01352; KRAB; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW Nucleus; Polymorphism; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 564 Zinc finger protein 211.
FT /FTId=PRO_0000047455.
FT DOMAIN 33 106 KRAB.
FT ZN_FING 131 157 C2H2-type 1.
FT ZN_FING 257 279 C2H2-type 2.
FT ZN_FING 285 307 C2H2-type 3.
FT ZN_FING 313 335 C2H2-type 4.
FT ZN_FING 341 363 C2H2-type 5.
FT ZN_FING 369 391 C2H2-type 6.
FT ZN_FING 397 419 C2H2-type 7.
FT ZN_FING 425 447 C2H2-type 8.
FT ZN_FING 453 475 C2H2-type 9.
FT ZN_FING 481 503 C2H2-type 10.
FT ZN_FING 509 531 C2H2-type 11.
FT ZN_FING 537 559 C2H2-type 12.
FT VAR_SEQ 1 72 MLGFPPGRPQLPVQLRPQTRMATALRDPASGSVTFEDVAVY
FT FSWEEWDLLDEAQKHLYFDVMLENFALTSSL -> MLENFA
FT LTSSLGLISSWSHVVAQLGLGEVPSVLHRMFMTPASARWDQ
FT RGPGLHEWHLGKGMSS (in isoform 2).
FT /FTId=VSP_035702.
FT VAR_SEQ 1 61 Missing (in isoform 5).
FT /FTId=VSP_035703.
FT VAR_SEQ 1 30 MLGFPPGRPQLPVQLRPQTRMATALRDPAS -> MRTLRQR
FT EVEYFSKATQLVRGSTKDRGAQVPIATEVLFKLTQ (in
FT isoform 3).
FT /FTId=VSP_035704.
FT VAR_SEQ 1 30 MLGFPPGRPQLPVQLRPQTRMATALRDPAS -> MISAYCN
FT LHLLGSSDSPASASQVAGTTGMRHHAQ (in isoform
FT 4).
FT /FTId=VSP_035705.
FT VAR_SEQ 1 20 Missing (in isoform 6).
FT /FTId=VSP_035706.
FT VAR_SEQ 30 30 S -> SVPIATEVLFKLTQ (in isoform 7).
FT /FTId=VSP_045643.
FT VARIANT 110 110 D -> N (in dbSNP:rs34897843).
FT /FTId=VAR_047278.
FT VARIANT 314 314 A -> V (in dbSNP:rs11879465).
FT /FTId=VAR_057402.
FT CONFLICT 178 178 V -> A (in Ref. 1; AK026941).
FT CONFLICT 276 276 Q -> L (in Ref. 1; BAG59491).
SQ SEQUENCE 564 AA; 64535 MW; 9506968ED6E36EE7 CRC64;
MLGFPPGRPQ LPVQLRPQTR MATALRDPAS GSVTFEDVAV YFSWEEWDLL DEAQKHLYFD
VMLENFALTS SLGCWCGVEH EETPSEQRIS GERVPQFRTS KEGSSSQNAD SCEICCLVLR
DILHLAEHQG TNCGQKLHTC GKQFYISANL QQHQRQHITE APFRSYVDTA SFTQSCIVHV
SEKPFTCREI RKDFLANMRF LHQDATQTGE KPNNSNKCAV AFYSGKSHHN WGKCSKAFSH
IDTLVQDQRI LTREGLFECS KCGKACTRRC NLIQHQKVHS EERPYECNEC GKFFTYYSSF
IIHQRVHTGE RPYACPECGK SFSQIYSLNS HRKVHTGERP YECGECGKSF SQRSNLMQHR
RVHTGERPYE CSECGKSFSQ NFSLIYHQRV HTGERPHECN ECGKSFSRSS SLIHHRRLHT
GERPYECSKC GKSFKQSSSF SSHRKVHTGE RPYVCGECGK SFSHSSNLKN HQRVHTGERP
VECSECSKSF SCKSNLIKHL RVHTGERPYE CSECGKSFSQ SSSLIQHRRV HTGKRPYQCS
QCGKSFGCKS VLIQHQRVHI GEKP
//
