ID Q148U5_MOUSE Unreviewed; 1299 AA.
AC Q148U5;
DT 22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT 22-AUG-2006, sequence version 1.
DT 24-JAN-2024, entry version 86.
DE SubName: Full=Plekhg1 protein {ECO:0000313|EMBL:AAI17966.1};
GN Name=Plekhg1 {ECO:0000313|EMBL:AAI17966.1,
GN ECO:0000313|MGI:MGI:2676551};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI17966.1};
RN [1] {ECO:0000313|EMBL:AAI17966.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=PCR rescued clones {ECO:0000313|EMBL:AAI17966.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; BC117965; AAI17966.1; -; mRNA.
DR AGR; MGI:2676551; -.
DR MGI; MGI:2676551; Plekhg1.
DR ChiTaRS; Plekhg1; mouse.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IBA:GO_Central.
DR CDD; cd13243; PH_PLEKHG1_G2_G3; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR043324; PH_PLEKHG1_G2_G3.
DR PANTHER; PTHR45924; FI17866P1; 1.
DR PANTHER; PTHR45924:SF1; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 21..201
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 225..324
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 363..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1122..1159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1207..1248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..396
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..649
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1207..1227
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1228..1244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1299 AA; 146062 MW; 0B2BF0BBDC49574A CRC64;
MDTSGTPQTT ADSATSPKLL YVDRVVQEIL ETERTYVQDL KSIVEGYLEC IRDQTKLPLV
TEDRAALFGN IQDIYHFNSE LLQDLENCEN DPVAIAECFV SKSEEFHIYT QYCTNYPRSV
AVLTECMRNK ILTKFFRERQ ETLRHSLPLG SYLLKPVQRI LKYHLLLHEI ENHLDKATEG
YDVVLDAIDT MQRVAWHIND MKRKHEHAVR LQEIQSLLTN WEGPDLTSYG ELVLEGTFRI
QKAKKERTLF LLDQLLLITK KRDDTFTYKA HILCGNLMLV EVIPKEPLSF SVFHYKNPKL
QHTVQAKSQQ DKRLWVLHLK RLILENHAAA AKIPAKAKQA ILEMDAIHYP GFCYSPEGEM
KTPCGSAPHR LRRKSEPSSR SHKVLKTSET SQDIQKVSRE ESPSQLTSAV PAQRNCQPGS
AAVINMLRGG GGVRSPWTDH HIRQRTDYHI RQPLFPSRRS PQENEDDDDD YQMFVPSFSS
SDLNSTRLCE ENASSRPCSW HLGLIEPTEI SSSGHRIVRR ASSAGESNAC PPEVRIRDCD
DSQYCPGRQL QNSPRPGGER GMTPYGSSVE LTIDDIDHVY DNISFEDLKL MVAKRDETEC
SFSKPSRDSV RPKSTPELAF SKRQVSHSTS SLHSRKEAGL GGQEASTQSV HEHQEVEENI
YDTIGLPDPP SMNLNHSSLH QPKRSTFLGL EADFACCDSL RPFVSQDSLQ FSEDDISYHQ
GPSDTEYLSL LYDSPRCNLP IADKALSDKL SEEVDEIWND LENYIKKNED KSRDRLLAAF
PVSKDDAPER LYVDSTHELG RDTGHATSML ALPTSQTFLL PGKSRVVRAS RANCSLDNDI
ISTEGSFLSL NQLSLASDGP PVDNPYDLAN CSLPQTDPEN PDPGMEVTDK TKSRVFMMAR
QYSQKIKKVN QILKVKSPEL EQPPSSQHRP SHKDLVAILE EKRQGGPAIG ARIAEYSQLY
DQIVFRETPL KAQKDGWASP QGPILHRPVS PPQAQGAGED WLWHSPYSNG ELADFSPQTE
QDSKSKYPIT LESTTKIRPR QLSGACSVPS LQVSDPLLGS VQQRCSVVVS QPHKENSGQS
PLYNSLGRKA ISTKPQPYSR PQSSSSILIN KSLDSINYPS ETETKQLLSS QKSPRGASQQ
DLPSGLANSC QQDRGKRSDL TLQDSQKVLV VNRNLPLSAQ IATQNYFCNF KDPEGDEDDY
VEIKSEEDEV RLDLSPRRGR KSDPQTPDPD CSDSICSHST PYSLKEPVSG RLGLPPYLTA
CKDSDKLNDY LWRGPSPNQQ NIVQSLREKF QCLSSSSFA
//
