ID Q14DP8_MOUSE Unreviewed; 846 AA.
AC Q14DP8;
DT 22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT 22-AUG-2006, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Slitrk2 protein {ECO:0000313|EMBL:AAI12407.1};
GN Name=Slitrk2 {ECO:0000313|EMBL:AAI12407.1,
GN ECO:0000313|MGI:MGI:2679449};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI12407.1};
RN [1] {ECO:0000313|EMBL:AAI12407.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=PCR rescued clones {ECO:0000313|EMBL:AAI12407.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the SLITRK family.
CC {ECO:0000256|ARBA:ARBA00010439}.
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DR EMBL; BC112406; AAI12407.1; -; mRNA.
DR AlphaFoldDB; Q14DP8; -.
DR PeptideAtlas; Q14DP8; -.
DR AGR; MGI:2679449; -.
DR MGI; MGI:2679449; Slitrk2.
DR ChiTaRS; Slitrk2; mouse.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007409; P:axonogenesis; IEA:InterPro.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IEA:UniProt.
DR GO; GO:1905606; P:regulation of presynapse assembly; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR InterPro; IPR043326; Slitrk.
DR PANTHER; PTHR45773:SF4; SLIT AND NTRK-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR45773; SLIT AND NTRK-LIKE PROTEIN 4-RELATED; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 10.
DR SMART; SM00082; LRRCT; 2.
DR SMART; SM00013; LRRNT; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS51450; LRR; 2.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..846
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004182997"
FT TRANSMEM 619..645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..64
FT /note="LRRNT"
FT /evidence="ECO:0000259|SMART:SM00013"
FT DOMAIN 216..264
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT DOMAIN 340..377
FT /note="LRRNT"
FT /evidence="ECO:0000259|SMART:SM00013"
FT DOMAIN 530..580
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT REGION 261..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 846 AA; 95482 MW; F61C57F88E224D0E CRC64;
MLSGVWFLSV LTVAGILQTE SRKTAKDICK IRCLCEEKEN VLNINCENKG FTTVSLLQPP
QYRIYQLFLN GNLLTRLYPN EFVNYSNAVT LHLGNNGLQE IRPGAFSCLK TLKRLHLNNN
KLEVLREDTF LGLESLEYLQ ADYNYISTIE AGAFSKLNKL KVLILNDNLL LSLPSNVFRF
VLLTHLDLRG NRLKVMPFAG VLEHIGGIME IQLEENPWNC TCDLLPLKAW LDTITVFVGE
IVCETPFRLH GKDVTQLTRQ DLCPRKSASG DSSQRSSHSD THVQRLTPTT NPALNPTRAP
KASRPPKMRN RPTPRVTVSK DRQSFGPIMV YQTKSPVALT CPSSCVCTSQ SSDNGLNVNC
QERKFTNISD LQPKPTSPKK LYLTGNYLQT VYKNDLLEYS SLDLLHLGNN RIAVIQEGAF
TNLTSLRRLY LNGNYLEVLY PSMFDGLQSL QYLYLEYNVI KEIKPLTFDA LINLQLLFLN
NNLLRSLPDN IFGGTALTRL NLRNNHFSHL PVKGVLDQLP AFIQIDLQEN PWDCTCDIMG
LKDWTEHANS PVIINEVTCE SPAKHAGEIL KFLGREAICP ENPNLSDGTI LSMNHNTDTP
RSLSVSPSSY PELHTEVPLS VLILGLLVVF ILSVCFGAGL FVFVLKRRKG VPNVPRNATN
LDVSSFQLQY GSYNTETNDK ADGHVYNYIP PPVGQMCQNP IYMQKEGDPV AYYRNLQDFS
YGNLEEKKEE PATLAYTISA TELLEKQATP REPELLYQNI AERVKELPSA GLVHYNFCTL
PKRQFAPSYE SRRQNQDRIN KTVLYGTPRK CFVGQSKPDH PLLQAKPQSE PDYLEVLEKQ
TAISQL
//
