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Database: UniProt
Entry: Q14K31
LinkDB: Q14K31
Original site: Q14K31 
ID   NUOH_FRAT1              Reviewed;         336 AA.
AC   Q14K31;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   01-OCT-2014, entry version 62.
DE   RecName: Full=NADH-quinone oxidoreductase subunit H {ECO:0000255|HAMAP-Rule:MF_01350};
DE            EC=1.6.99.5 {ECO:0000255|HAMAP-Rule:MF_01350};
DE   AltName: Full=NADH dehydrogenase I subunit H {ECO:0000255|HAMAP-Rule:MF_01350};
DE   AltName: Full=NDH-1 subunit H {ECO:0000255|HAMAP-Rule:MF_01350};
GN   Name=nuoH {ECO:0000255|HAMAP-Rule:MF_01350};
GN   OrderedLocusNames=FTF0038;
OS   Francisella tularensis subsp. tularensis (strain FSC 198).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=393115;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FSC 198;
RX   PubMed=17406676; DOI=10.1371/journal.pone.0000352;
RA   Chaudhuri R.R., Ren C.-P., Desmond L., Vincent G.A., Silman N.J.,
RA   Brehm J.K., Elmore M.J., Hudson M.J., Forsman M., Isherwood K.E.,
RA   Gurycova D., Minton N.P., Titball R.W., Pallen M.J., Vipond R.;
RT   "Genome sequencing shows that European isolates of Francisella
RT   tularensis subspecies tularensis are almost identical to US laboratory
RT   strain Schu S4.";
RL   PLoS ONE 2:E352-E352(2007).
CC   -!- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-
CC       sulfur (Fe-S) centers, to quinones in the respiratory chain. The
CC       immediate electron acceptor for the enzyme in this species is
CC       believed to be ubiquinone. Couples the redox reaction to proton
CC       translocation (for every two electrons transferred, four hydrogen
CC       ions are translocated across the cytoplasmic membrane), and thus
CC       conserves the redox energy in a proton gradient. This subunit may
CC       bind ubiquinone. {ECO:0000255|HAMAP-Rule:MF_01350}.
CC   -!- CATALYTIC ACTIVITY: NADH + quinone = NAD(+) + quinol.
CC       {ECO:0000255|HAMAP-Rule:MF_01350}.
CC   -!- SUBUNIT: NDH-1 is composed of 14 different subunits. Subunits
CC       NuoA, H, J, K, L, M, N constitute the membrane sector of the
CC       complex. {ECO:0000255|HAMAP-Rule:MF_01350}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01350}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01350}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_01350}.
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DR   EMBL; AM286280; CAL08054.1; -; Genomic_DNA.
DR   RefSeq; YP_666245.1; NC_008245.1.
DR   STRING; 393115.FTF0038; -.
DR   EnsemblBacteria; CAL08054; CAL08054; FTF0038.
DR   GeneID; 4200747; -.
DR   KEGG; ftf:FTF0038; -.
DR   PATRIC; 17958692; VBIFraTul133500_0041.
DR   eggNOG; COG1005; -.
DR   HOGENOM; HOG000228276; -.
DR   KO; K00337; -.
DR   OMA; AMWYIST; -.
DR   OrthoDB; EOG6B62B4; -.
DR   BioCyc; FTUL393115:GJUT-38-MONOMER; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050136; F:NADH dehydrogenase (quinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0048038; F:quinone binding; IEA:UniProtKB-KW.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Complete proteome; Membrane; NAD;
KW   Oxidoreductase; Quinone; Transmembrane; Transmembrane helix;
KW   Ubiquinone.
FT   CHAIN         1    336       NADH-quinone oxidoreductase subunit H.
FT                                /FTId=PRO_0000298814.
FT   TRANSMEM      4     24       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01350}.
FT   TRANSMEM     75     95       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01350}.
FT   TRANSMEM    108    128       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01350}.
FT   TRANSMEM    154    174       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01350}.
FT   TRANSMEM    181    201       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01350}.
FT   TRANSMEM    233    253       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01350}.
FT   TRANSMEM    272    292       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01350}.
FT   TRANSMEM    308    328       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01350}.
SQ   SEQUENCE   336 AA;  37642 MW;  28F125A9F17D822D CRC64;
     MLGYILWTSL YVLLIVIPLI LVVAYYTYAE RKVIGYMQDR IGPNRVGSFG LLQPIFDALK
     LFLKEIIVPT NSNRYLFFIA PILAFAPAYA AWAVIPFSKG VVLSDMNLGL LYILAMTSFS
     IYGIVIAGWA SNSKYSLFGA LRAGAQVISY ELAMGFAIVG VVIAAGSMGI TGIIEAQSGG
     IWHWYFIPLF PLFIVYFIAG IAETNRAPFD VVEGESEIVA GHHIEYTGSR FALFFLAEYA
     NMILISILTS IMFLGGWNSP FQATALESIF GFVPGVVWLF AKTGIFMFMF LWVRATYPRY
     RYDQIMRLGW KIFIPLTFVW VVIVACMVRL GVGPWW
//
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