ID Q153G7_CAPHI Unreviewed; 179 AA.
AC Q153G7;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=Insulin-like growth factor II {ECO:0000256|ARBA:ARBA00018566};
GN Name=IGF2 {ECO:0000313|EMBL:ABG33777.1,
GN ECO:0000313|Ensembl:ENSCHIP00000023369.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|EMBL:ABG33777.1};
RN [1] {ECO:0000313|EMBL:ABG33777.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17707215; DOI=10.1016/S1673-8527(07)60080-0;
RA Xing B., Xu Y., Cheng Y., Liu H., Du M.;
RT "Overexpression of IGF2R and IGF1R mRNA in SCNT-produced goats survived to
RT adulthood.";
RL J. Genet. Genomics 34:709-719(2007).
RN [2] {ECO:0000313|EMBL:ADD12956.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Liver {ECO:0000313|EMBL:ADD12956.1};
RA Kumar A., Mitra A.;
RT "Molecular cloning and characterization of IGF II gene in black bengal
RT goat.";
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AEP81448.1}
RP NUCLEOTIDE SEQUENCE.
RA Mu X., Zi X.;
RT "Single Nucleotide Polymorphism (SNP), cDNA Cloning and Tissue Expression
RT of GH, IGF-I, and IGF-II Genes in Lezhi Black Goat.";
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AEP81448.1}
RP NUCLEOTIDE SEQUENCE.
RA Zi X.-D., Mu X.-K., Wang Y.;
RT "Variation in sequences and mRNA expression levels of growth hormone (GH),
RT insulin-like growth factor I (IGF-I) and II (IGF-II) genes between prolific
RT Lezhi black goat and non-prolific Tibetan goat (Capra hircus).";
RL Gen. Comp. Endocrinol. 187:1-5(2013).
RN [5] {ECO:0000313|EMBL:ALZ41703.1}
RP NUCLEOTIDE SEQUENCE.
RA Naicy T., Venkatachalapathy R.T.;
RT "Cloning and expression of caprine IGF2 mRNA.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|Ensembl:ENSCHIP00000023369.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|Ensembl:ENSCHIP00000023369.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Preptin undergoes glucose-mediated co-secretion with insulin,
CC and acts as a physiological amplifier of glucose-mediated insulin
CC secretion. Exhibits osteogenic properties by increasing osteoblast
CC mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
CC {ECO:0000256|ARBA:ARBA00043916}.
CC -!- FUNCTION: The insulin-like growth factors possess growth-promoting
CC activity (By similarity). Major fetal growth hormone in mammals. Plays
CC a key role in regulating fetoplacental development. IGF2 is influenced
CC by placental lactogen. Also involved in tissue differentiation. In
CC adults, involved in glucose metabolism in adipose tissue, skeletal
CC muscle and liver. Acts as a ligand for integrin which is required for
CC IGF2 signaling. Positively regulates myogenic transcription factor
CC MYOD1 function by facilitating the recruitment of transcriptional
CC coactivators, thereby controlling muscle terminal differentiation (By
CC similarity). Inhibits myoblast differentiation and modulates metabolism
CC via increasing the mitochondrial respiration rate.
CC {ECO:0000256|ARBA:ARBA00025573}.
CC -!- SUBUNIT: Interacts with MYORG; this interaction is required for IGF2
CC secretion. Interacts with integrins ITGAV:ITGB3 and ITGA6:ITGB4;
CC integrin-binding is required for IGF2 signaling.
CC {ECO:0000256|ARBA:ARBA00011472}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR EMBL; LWLT01000026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DQ645739; ABG33777.1; -; mRNA.
DR EMBL; GQ246165; ADD12956.1; -; mRNA.
DR EMBL; JF896277; AEP81448.1; -; mRNA.
DR EMBL; JF896278; AEP81449.1; -; mRNA.
DR EMBL; KT445943; ALZ41703.1; -; mRNA.
DR EMBL; KT445944; ALZ41704.1; -; mRNA.
DR RefSeq; NP_001273970.1; NM_001287041.1.
DR STRING; 9925.ENSCHIP00000023369; -.
DR Ensembl; ENSCHIT00000031229.1; ENSCHIP00000023369.1; ENSCHIG00000020968.1.
DR GeneID; 100861277; -.
DR KEGG; chx:100861277; -.
DR CTD; 3481; -.
DR GeneTree; ENSGT00940000160745; -.
DR OMA; DERCRQP; -.
DR OrthoDB; 5402912at2759; -.
DR Proteomes; UP000291000; Chromosome 29.
DR Bgee; ENSCHIG00000020968; Expressed in metanephros cortex and 15 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0005158; F:insulin receptor binding; IEA:Ensembl.
DR GO; GO:0005159; F:insulin-like growth factor receptor binding; IEA:Ensembl.
DR GO; GO:0005178; F:integrin binding; IEA:Ensembl.
DR GO; GO:0043539; F:protein serine/threonine kinase activator activity; IEA:Ensembl.
DR GO; GO:0030297; F:transmembrane receptor protein tyrosine kinase activator activity; IEA:Ensembl.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
DR GO; GO:0060669; P:embryonic placenta morphogenesis; IEA:Ensembl.
DR GO; GO:0031017; P:exocrine pancreas development; IEA:Ensembl.
DR GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0051148; P:negative regulation of muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; IEA:Ensembl.
DR GO; GO:0046628; P:positive regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
DR GO; GO:0046622; P:positive regulation of organ growth; IEA:Ensembl.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0048633; P:positive regulation of skeletal muscle tissue growth; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0060720; P:spongiotrophoblast cell proliferation; IEA:Ensembl.
DR GO; GO:0051146; P:striated muscle cell differentiation; IEA:Ensembl.
DR CDD; cd04368; IlGF; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR022334; IGF2.
DR InterPro; IPR013576; IGF2_C.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR022350; Insulin-like_growth_factor.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR46886; INSULIN-LIKE GROWTH FACTOR II; 1.
DR PANTHER; PTHR46886:SF1; INSULIN-LIKE GROWTH FACTOR II; 1.
DR Pfam; PF08365; IGF2_C; 1.
DR Pfam; PF00049; Insulin; 2.
DR PRINTS; PR02002; INSLNLIKEGF.
DR PRINTS; PR02006; INSLNLIKEGF2.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 2: Evidence at transcript level;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR622350-50};
KW Glucose metabolism {ECO:0000256|ARBA:ARBA00022526};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Mitogen {ECO:0000256|ARBA:ARBA00023246};
KW Osteogenesis {ECO:0000256|ARBA:ARBA00022855};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..179
FT /note="Insulin-like growth factor II"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007699357"
FT DOMAIN 30..84
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
FT REGION 160..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 33..71
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 45..84
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 70..75
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
SQ SEQUENCE 179 AA; 19654 MW; A76BE5BEA51780DA CRC64;
MGITAGKSML VLLAFLAFAS CCYAAYRPSE TLCGGELVDT LQFVCGDRGF YFSRPSSRIN
RRSRGIVEEC CFRSCDLALL ETYCAAPAKS ERDVSASTTV LPDDFTAYPV GKFFQSDTWK
QSTQRLRRGL PAFLRARRGR TLAKELEALR EAKSHRPLIA LPTQDPATHG GASPEASSD
//
