ID Q15I74_PIG Unreviewed; 86 AA.
AC Q15I74;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE RecName: Full=Ras-related GTP-binding protein {ECO:0000256|RuleBase:RU367014};
DE Flags: Fragment;
GN Name=RRAGD {ECO:0000313|EMBL:ABC58681.1};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:ABC58681.1};
RN [1] {ECO:0000313|EMBL:ABC58681.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16783645; DOI=10.1007/s00335-005-0188-7;
RA Grapes L., Rothschild M.F.;
RT "Investigation of a QTL region for loin eye area and fatness on pig
RT chromosome 1.";
RL Mamm. Genome 17:657-668(2006).
CC -!- FUNCTION: Guanine nucleotide-binding protein that plays a crucial role
CC in the cellular response to amino acid availability through regulation
CC of the mTORC1 signaling cascade. {ECO:0000256|RuleBase:RU367014}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU367014}.
CC Lysosome {ECO:0000256|RuleBase:RU367014}.
CC -!- SIMILARITY: Belongs to the GTR/RAG GTP-binding protein family.
CC {ECO:0000256|ARBA:ARBA00007756, ECO:0000256|RuleBase:RU367014}.
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DR EMBL; AH015505; ABC58681.1; -; Genomic_DNA.
DR AlphaFoldDB; Q15I74; -.
DR HOGENOM; CLU_047421_1_1_1; -.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:UniProtKB-UniRule.
DR GO; GO:0032008; P:positive regulation of TOR signaling; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR006762; Gtr1_RagA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11259; RAS-RELATED GTP BINDING RAG/GTR YEAST; 1.
DR PANTHER; PTHR11259:SF5; RAS-RELATED GTP-BINDING PROTEIN D; 1.
DR Pfam; PF04670; Gtr1_RagA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU367014};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU367014};
KW Lysosome {ECO:0000256|RuleBase:RU367014};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU367014}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABC58681.1"
FT NON_TER 86
FT /evidence="ECO:0000313|EMBL:ABC58681.1"
SQ SEQUENCE 86 AA; 9954 MW; F96D0ACA2F2125C0 CRC64;
TRAYKVNTDI NFEVFIHKVD GLSDDHKIET QRDIHQRAND DLADAGLEKI HLSFYLTSIY
DHSIFEAFSK VVQKLIPQLP TLENLL
//
