ID   Q164T4_ROSDO            Unreviewed;       499 AA.
AC   Q164T4;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   27-MAR-2024, entry version 100.
DE   RecName: Full=methylmalonate-semialdehyde dehydrogenase (CoA acylating) {ECO:0000256|ARBA:ARBA00013048};
DE            EC=1.2.1.27 {ECO:0000256|ARBA:ARBA00013048};
GN   Name=mmsA {ECO:0000313|EMBL:ABG32509.1};
GN   OrderedLocusNames=RD1_2990 {ECO:0000313|EMBL:ABG32509.1};
OS   Roseobacter denitrificans (strain ATCC 33942 / OCh 114) (Erythrobacter sp.
OS   (strain OCh 114)) (Roseobacter denitrificans).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Roseobacter.
OX   NCBI_TaxID=375451 {ECO:0000313|EMBL:ABG32509.1, ECO:0000313|Proteomes:UP000007029};
RN   [1] {ECO:0000313|EMBL:ABG32509.1, ECO:0000313|Proteomes:UP000007029}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33942 / OCh 114 {ECO:0000313|Proteomes:UP000007029};
RX   PubMed=17098896; DOI=10.1128/JB.01390-06;
RA   Swingley W.D., Sadekar S., Mastrian S.D., Matthies H.J., Hao J., Ramos H.,
RA   Acharya C.R., Conrad A.L., Taylor H.L., Dejesa L.C., Shah M.K.,
RA   O'huallachain M.E., Lince M.T., Blankenship R.E., Beatty J.T.,
RA   Touchman J.W.;
RT   "The complete genome sequence of Roseobacter denitrificans reveals a
RT   mixotrophic rather than photosynthetic metabolism.";
RL   J. Bacteriol. 189:683-690(2007).
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DR   EMBL; CP000362; ABG32509.1; -; Genomic_DNA.
DR   RefSeq; WP_011569125.1; NZ_FOOO01000002.1.
DR   AlphaFoldDB; Q164T4; -.
DR   STRING; 375451.RD1_2990; -.
DR   KEGG; rde:RD1_2990; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_1_10_5; -.
DR   OrthoDB; 9812625at2; -.
DR   Proteomes; UP000007029; Chromosome.
DR   GO; GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity; IEA:UniProtKB-EC.
DR   CDD; cd07085; ALDH_F6_MMSDH; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR010061; MeMal-semiAld_DH.
DR   NCBIfam; TIGR01722; MMSDH; 1.
DR   PANTHER; PTHR43866; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR43866:SF4; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:ABG32509.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007029}.
FT   DOMAIN          15..479
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
SQ   SEQUENCE   499 AA;  53737 MW;  91B462ABBDC5B07D CRC64;
     MQDLTHYLNG EHVAGTSGRF ADVMNPATGE VQARVPLASS AEIDRAVEIA ASVQPAWAAI
     NPQRRARVLM KFVDLLNRDM DKLAEALSRE HGKTLPDAAG DVQRGLEVVE YCIGAPHLLK
     GEYTDSAGPG IDMYSMRQPL GVSAGITPFN FPAMIPMWMF APAIACGNAF ILKPSERDPS
     VPLMLAELFE EAGLPKGVLQ VVNGDKEAVD AILHHDVIQS IGFVGSTPIA EYIYGTGCAN
     GKRVQCFGGA KNHMIIMPDA DMDQAADALV GAGYGAAGER CMAISVAVPV GDETADRLIE
     KLVPRIEKLK VGPYTAGNDV DYGPVVTAAA KANIERLVET GVAQGAKLVV DGRNFNLQGY
     ENGFFIGPHL FDHVTRDMDI YKHEIFGPVL STVRAQSYEE ALSLAMDHEY GNGTAIFTRD
     GDAARDFANR VNVGMVGINV PIPVPLAYHT FGGWKKSVFG DLNQHGPDAF KFYTRTKTVT
     SRWPSGIKEG GEFSIPVME
//