ID Q16EQ1_AEDAE Unreviewed; 2414 AA.
AC Q16EQ1;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:AAEL015065-PA};
GN Name=5566099 {ECO:0000313|EnsemblMetazoa:AAEL015065-PA};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EnsemblMetazoa:AAEL015065-PA, ECO:0000313|Proteomes:UP000008820};
RN [1] {ECO:0000313|EnsemblMetazoa:AAEL015065-PA, ECO:0000313|Proteomes:UP000008820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL015065-PA,
RC ECO:0000313|Proteomes:UP000008820};
RG Aedes aegypti Genome Working Group (AGWG);
RA Matthews B.J.;
RT "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AAEL015065-PA}
RP IDENTIFICATION.
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL015065-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826}.
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DR RefSeq; XP_001650465.1; XM_001650415.1.
DR STRING; 7159.Q16EQ1; -.
DR PaxDb; 7159-AAEL015065-PA; -.
DR EnsemblMetazoa; AAEL015065-RA; AAEL015065-PA; AAEL015065.
DR GeneID; 5566099; -.
DR KEGG; aag:5566099; -.
DR VEuPathDB; VectorBase:AAEL015065; -.
DR eggNOG; KOG0040; Eukaryota.
DR HOGENOM; CLU_000847_0_0_1; -.
DR OMA; FQIAQEE; -.
DR Proteomes; UP000008820; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR CDD; cd00051; EFh; 1.
DR CDD; cd11808; SH3_Alpha_Spectrin; 1.
DR CDD; cd00176; SPEC; 13.
DR Gene3D; 1.20.58.60; -; 19.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035825; Alpha_Spectrin_SH3.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014837; EF-hand_Ca_insen.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF422; PH_9 DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF08726; EFhand_Ca_insen; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF00435; Spectrin; 20.
DR PRINTS; PR00452; SH3DOMAIN.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00054; EFh; 2.
DR SMART; SM01184; efhand_Ca_insen; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00150; SPEC; 20.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 16.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008820};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443}.
SQ SEQUENCE 2414 AA; 277960 MW; 26155465B5E290C7 CRC64;
MEQFTPKEVK ILESAEDIQE RREQVLNRYN EFKVETRHKR EKLEDSRRFQ YFKRDSDELE
SWIHEKLQAA SEESYRDPTN LQAKIQKHQA FEAEVSAHSN AIVVLDNTGQ EMINQHHFAS
DTIQRRLDEL HRLWELLLSR LAEKGMKLQQ ALVLVQFLRH CEEVMFWIKD KEAFVTADEF
GQDLEHVEVL QRKFDEFQKD MASQEYRVTE VNELADKLLS NGHPERETIT RKKEELNEAW
QRLKQLAILR QEKLFGAHEI QRFNRDADET VAWIAEKDVV LSSDDYGRDL ASVQALQRKH
EGVERDLAAL EDKVATLGAE AGRLCSIHAD HSDQIREKQA EIAAYWQSLT AKAKERKQKL
DESYFLHRFL ADFRDLVSWI NGMKAIISAD ELAKDVAGAE ALLERHQEHK GEIDARGDSF
KVTTEAGRQL LEREHYAAAE VQEKLAALES DKSSLLALWE ERRILYEQCM DLQLFYRDTE
QADTWMAKQE AFLANEDLGD SLDSVEALIK KHEDFEKSLA AQEEKIKALD VFATKLIDGQ
HYAADDVAQR RSMLLARRSA LLEKSSVRRQ LLEDSSALQQ FERDCDETKG WISEKLKFAT
DDSYLDPTNL NGKVQKHTNF EHELTANKSR IEDITTNGQN LVEKGHYGAD QINSRMQEIV
TLWESLVQSS DKKGCKLQEA SQQQQFNRTV EDIELWLSEV EGQLMSEDYG KDLTSVQNLQ
KKHGLLEADV MAHQDRIEGI KVAANKFVES GHFDADNIRN KESALSKRYG ALATPMAERK
QRLLDSLQVQ QLFRDLEDEA AWIREKEPVA ASTNRGRDLI GVQNLIKKHQ AVLAEINNHE
NRVAGVIANG EQMLTEQPFA TEDIKLRLDA VKDQWNSLKE KANQRKQDLE DSLQAHQYFA
DANEAESWMR EKEPIVSNQD YGKDEDSSEA LLKKHEALVS DLEAFGNTIQ ALQEQAKNCR
QQETPVVDIT GKECVMALYD YTEKSPREVS MKKGDVLTLL NSNNKDWWKV EVNDRQGFVP
AAYIKKIDPG LSASQQNLVD GHSIAKRQAQ INSQYDNLLA LARERQNKLN ETVKAYVLVR
EAADLSAWIR DKESHAQIKD VGEDLEEVEV MQKKFDDFND DLKANEVRLA KLNEIAVQLT
SLGQTEAALK IKTQIQTLNE EWTVLQNITQ ERASQLGSAH EVQRFHRDVD ETKDWIGEKD
TALTNDDLGK DLRGVQTLQR KHEGLERDLA ALRDKIRQLD ETANRLMQSH PETAEQTYAK
QKEINEEWQQ VVAKTQQRKE KLLDSYDLQR FLSDYRDLMA WISSMMGLVT SEELANDVTG
AEALIERHQE HRTEVDARAG TFAAFDQFGA ELLQANHYAS PEIQEKIENL AKAREDLERA
WTARRLQLDQ NLDLQLYLRD CEQAENWMSA REAFLNAEEV DSKGDNVEAL IKKHEDFDKA
INGHEEKIAA LQVLADQLIA QEHYAGKLID DKRADVLDRW RHLKEDLIEK RSRLGDEQTL
QQFSRDADEI ENWIAEKLQL ATEESYKDPA NIQSKHQKHQ AFEAELAANA DRIQSVLAMG
SNLIDKNQCS GSEDAVQKRL TQIADQWEYL TQKTTEKSLK LKEANKQRTY IAAVKDLDFW
LGEVESLLTS EDAGKDLASV QNLMKKHQLV EADIHAHEDR IKDMNAQADS LVESGQFDSA
GIQEKRQSIN ERYERICNLA AHRQARLNEA NTLHQFFRDI ADEESWIKEK KLLVGSDDYG
RDLTGVQNLK KKHKRLEAEL ASHEPAIQAV QEAGEKLMDV SNLGVPEIEQ RLKALNQAWA
ELKSLAATRG QKLDESLIYQ QFLAKVEEEE AWITEKQQLL SVEDYGDSMA AVQGLLKKHD
AFETDFAAHR DRCADIHDNG QTLVTNNNHH AESISQRCTQ LDKKLENLQA LATRRKSALL
DNFAYLQFMW KADVVESWIA DKENHVKSEE FGRDLSTVQT LLTKQETFDA GLSAFEHEGI
HNITALKDQL INANHAQSAA ILKRHEDVLT RWQKLRADSE ARKYRLLAMQ EQFRQIEDLY
LTFAKKASAF NSWFENAEED LTDPVRCNSI EEIKALREAH AQFQASLSSA QYDFQALADL
DRKIKSFNVG PNPYTWFTME ALEDTWRNLQ KIIEERDAEL AKEVHRQEEN DKLRKEFAKH
ANLFHQWLTE TRTSLMDGSG SLEEQFEALC HKANEIRARR GDLKKIEELG ATLEEHLILD
NRYTEHSTVG LAQQWDQLDQ LAMRMQHNLR QQIQARNQSG VSEDSLKEFS MMFKHFDKDK
SGKLNHQEFK SCLRALGYDL PMVEEGQPDP EFEEILNVVD PNRDGHVSLQ EYIAFMISKE
TENVQSYEEI ENAFRAITAS DRPYVTKDEL YSNLTKDMAD YCVQRMKPFN DPKTGHPITG
ALDYVEFTRT LFQN
//
