ID Q16EU1_AEDAE Unreviewed; 2722 AA.
AC Q16EU1;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 24-JAN-2024, entry version 117.
DE SubName: Full=AAEL015015-PA {ECO:0000313|EMBL:EAT32755.1};
GN ORFNames=AAEL015015 {ECO:0000313|EMBL:EAT32755.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT32755.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT32755.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT32755.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT32755.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT32755.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT32755.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT32755.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CH478580; EAT32755.1; -; Genomic_DNA.
DR RefSeq; XP_001650336.1; XM_001650286.1.
DR STRING; 7159.Q16EU1; -.
DR PaxDb; 7159-AAEL015015-PA; -.
DR VEuPathDB; VectorBase:AAEL021323; -.
DR eggNOG; KOG1473; Eukaryota.
DR eggNOG; KOG1632; Eukaryota.
DR OMA; PEQYTNV; -.
DR PhylomeDB; Q16EU1; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0016589; C:NURF complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd05509; Bromo_gcn5_like; 1.
DR CDD; cd15559; PHD1_BPTF; 1.
DR CDD; cd15560; PHD2_3_BPTF; 2.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR InterPro; IPR038028; BPTF.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45975; NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF; 1.
DR PANTHER; PTHR45975:SF2; NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF00628; PHD; 3.
DR Pfam; PF15613; WSD; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00249; PHD; 3.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 3.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 206..266
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 357..404
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2482..2533
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2538..2589
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2616..2686
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1121..1177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1416..1440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1466..1530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1585..1631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1897..1917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2311..2374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2408..2475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1416..1430
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1466..1523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1585..1610
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2329..2347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2416..2433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2434..2475
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2722 AA; 306123 MW; BF284C8FE78A5BE1 CRC64;
MSSRKSAAAA GEGSSAGKRR GRPPKSQSSA MERPKSKFQY HLLKKPKYLC KDGSNGDSRF
STPSASRASS PQGSEESRPS TSRRSAPAKA PRSAKAAKGR KSTGGRGRGG NNRKSYTYHE
SEYHYGSDFG DDSDKSDGYD DSMRSASDSE DSLANESESD FSIHSFSAST GIICQKEPSP
DPVWLQDRDY PPLELPASSE DLLVPNNIVL KCTSIYEIIR RFRNLVRLSP FRLEDFAAAI
MCEDQSPLLT EIHIMLLKAI LREEDSQQTH FAPLDQKDSV NIALYLIDSI TWPEVLRSYI
ESDPSLDQQV LEVLTVNEYP FVAPEDRLKV LQFLTDQFLV TTTVRDDMLQ EGPIHYDDHC
RICHRLGDLL CCETCPAVFH LECVDPPLVD VPSEDWQCNL CKLHKVSGVM DCITSQEKQG
MLCRQELLGY DRHGRKYWFI GRRIFIETED SSDVWYFSTV KQFEYLLSKL DPVDLEMHLC
KELDERRDEI IRHMTLTETI TSQQKGNKKS YFELDNQRLE KLMEEEGLAT KDADEKMDVD
DQKGAGDKDE ESRLTRNKLT QISNGTLHFK LGMENGFKAY VNQYSINPIA LNKPQRNEDR
DKKRHLSHKF SLTQASEFKW LGGGMNSTQT QIISTIKQSI IALEQAVASP FLHQNWSKLR
KTWIGAISAC TKAKDFARIL CILQACMRSV IFASVWHEQL GHTKMYKITS AEREEKKKLE
KREKRERDDE EERNRSTFNF VKYSLGLRHQ VWKQKGEEYR IHGQWDWVWM SYSRRKGKKP
SRETNEISHV LIPIVAEVHK KLLKLDSKTH KAYQLVRVGS TDLDFMTGNE ALDSRLEEKF
NQTETFQVPE TFDVIDVSKA LSTPGGRILY PKIAKTASVL DGLLQRRVDL KEAEERKIAK
VKDEEDISVN VIHKPETVQA RLGECVEKQL QSIINSRHNV NVRNSLPLNK QPINRSNGEQ
VEPLIEKILP LRSKYQDVNA VVQTNKCYSL DCENGLCYSP LCLQKQAIKD ELLPLLKKVQ
ALQSTPMANP TIAGVKSILE QKLTEYKAEN FDSMLANFSM NRYRSILDEW DSAHMHLIEY
DEQLIQSMAA PKMPEEHNNN VTNEVEIKTE DAPDMVVKEE IVSTEGEPDL NGSERMDDSL
KLNENSNSIS ENSCDEPRST RRGRPRSSKN NSMVIEDTEV KVKEEEVMIL PKKEHKPNRR
FALPSRCVKK EDSEDKELAP DGSTRVYSVS STKGKIYLRK ALEPEVKVKS ETKPAAAVVG
PVKPKYPAVN YFWTRKQTTS MMVLPMHELL KLARNGGRLS AAGFHHMAKN NNSVWPYPCA
RPLFKTCWLY RTLNLSTLSA VGLQLRIIWT CLRWDDMAMK PATSDGKHQV TTESEIMSLE
ILKHRFAGIF HERMQYLRRK VVIPLELPKT VREVQSIRSG LRKRKRAESP QQTEPQVSEE
WIDEDKLELW EIKLYGEKQE KLAAAQAQHV TRTSTGKLPI TRQTPSTSGE SSNSSTSTTS
GNSGNNASTT NVQNKSAVIS SKASREEITE KMEQQLRIQR AAHNQKRAME LKQQDGATPP
KQTIVQRRII VKNADGTTKV IQQNITQPAR ASPASATTAA TSSPQAQQAS PAPAKPDGPQ
KVQIIRGPDG KVSVRGLNPG QQLIQTADGK LHVLSAAPAT SVTVTSPTAV TQPQPQQIQV
QPQQVQIQPQ QQAAPVVVSS PTVTQQIVNK SPSIVVRNQA GQPIKQIIQK QVVQKVSLRN
CGQLIATTGS PVQKVVTQSN LQQLLQGAGQ KVVVESNTGQ SPVQTQKVLV ATSPPGQPVQ
KQILIQNATP GSPQQIIINQ AGGQKVVQQI VASPGQQIMI GGQRIMIGGG QKIISNQPIQ
IQQNQQIQQI QQIQQVQQKV QQVHQIVTST PQPQQPQQIQ IQIQQPVAQP PPQPQLQTIQ
AQPAPLTQGQ SLTQQLSSGK LQLANLNGQQ VLIRPLGNNQ AQVVAHIKTQ PNGTAQIIPL
ANAVDPPPAP VQPQTIQQVV QAAPTQQATI QQVVQQPVTQ TTIVQQAFNT SGGSQTTFQQ
LAAATQQQQL QQQQQQQQLD PVEQTLLQGQ PPGTVIKCVT AQVIQTQQGP RIVLQGLQGS
EFTPQQSALV QQQVKQQLLK AQESNGKQGV LGPTKIYLAI QPSQQQVVAA QPPPLAPVQI
KHDGGTTHIQ LHQQVSSHQE SRYYTSRSYF ILQADSTVTT TTPTVEDSEL PVSGSLTTTI
KTAASTSNND NKPQILSNIV INDAKTSEEK DDSFVVTPDY IQQTIKNALK QENLNPEIEE
KLLNLQRYQE KQMKTDDRSA AIALQHNYSN MSSNREHHHH HSTPVKSKKR SHRGEDDDDE
WMMDTPKRRP TKSGGSSLSS VERKAQLNRH KEQLKKDILK KRSHLERELQ VQIQKELSTE
LAARCKQEQQ QIKQEHSGKQ HATAAATPST PAEKGSHSKK RSSASVSKED KVQKTPKHAQ
GSSKAEKASK ASGKKGSKKK EKILCLCRTP YDDTKFYVGC DLCHNWFHGD CVGISEEQSK
EIDEFVCSEC KHARETQELY CLCKQPYDES QFYICCDKCQ DWFHGRCVGI LQSEAEFIDE
YICPNCQINN SVNFANMKSL SAKEFDNLKK LIKQIQHHKS AWPFMEPVDP DEAPDYYRVI
KEPMDLQKVE NKVNNQTYHT LSEFIGDMTK IFDNCRYYNP KESQFYRCAE SLESFFVQKI
KFFRENLVEK KSAGTSSTST SV
//
