ID Q16GK5_AEDAE Unreviewed; 2895 AA.
AC Q16GK5;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 139.
DE SubName: Full=AAEL014347-PA {ECO:0000313|EMBL:EAT33370.1};
GN ORFNames=AAEL014347 {ECO:0000313|EMBL:EAT33370.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT33370.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT33370.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT33370.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT33370.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT33370.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT33370.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT33370.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; CH478268; EAT33370.1; -; Genomic_DNA.
DR RefSeq; XP_001648539.1; XM_001648489.1.
DR PaxDb; 7159-AAEL014347-PA; -.
DR GeneID; 5564197; -.
DR KEGG; aag:5564197; -.
DR VEuPathDB; VectorBase:AAEL014347; -.
DR eggNOG; KOG1388; Eukaryota.
DR HOGENOM; CLU_000612_0_0_1; -.
DR OMA; PVCQWCD; -.
DR OrthoDB; 5471913at2759; -.
DR PhylomeDB; Q16GK5; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00055; EGF_Lam; 3.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 4.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR46093; ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5; 1.
DR PANTHER; PTHR46093:SF17; MULTIPLE EGF-LIKE-DOMAINS 8; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF13418; Kelch_4; 4.
DR Pfam; PF00053; Laminin_EGF; 4.
DR Pfam; PF01437; PSI; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00180; EGF_Lam; 4.
DR SMART; SM00423; PSI; 9.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF117281; Kelch motif; 2.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01248; EGF_LAM_1; 3.
DR PROSITE; PS50027; EGF_LAM_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2707..2731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 74..186
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1199..1240
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1275..1321
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1322..1376
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1356..1502
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1532..1568
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 1293..1302
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1305..1319
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1344..1353
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1558..1567
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2895 AA; 322361 MW; E7CEED95ACA5DA82 CRC64;
MDWSSETLLD ALSSPPSKEH RTEAIQLLSL HKQQQFHRHN FGAQKMLFLL LLLCSLPLVT
VELALTKSSQ HQSCDKTRRV FTEPYGEISD GPSGYNYTQD SHCEWLIRAQ NDSQFITLTF
RSMGTECSYD YIFIYDGDSF RSPLLGSFSG KTEPQRVLAA SGSMLVLLYS DTNYVLEGFK
AEFSVTNCPN NCTNHGKCID HSCVCEYNWI GLDCSLDACP DGCGQDEGRG QCSNGKCVCS
SEYSGQSCSL HKSRPVPNEW HWLSNSKNGL TPRATHAAVY YAPSDSLYVF GGYNLNHVLD
SLQIYRFAKS IWENEWGMRV SPQEEPHVVD TTDEKSQMGV WLSEEPSGPN FFNNVIYSLA
DNRTGPFGGM YANRSRPAGR YGHAACAVED GFVIFGGKLA GGRLSHDLWL YNISHNNGTW
SERARTSSFQ PPSLTRHTLT LANGYIYVFG GALESGEFSS RLFRIRLSNN PAEEQWEEVI
PRGGKTLDIR IVAHTTSYHR HSKSLIVYGG VVAGVARFSK LSDRMFSFHL EHLHWAEIMY
PRTPLRDAYI PRERAFHTTT INGNYLIVFG GYTHRHNKEE ICYDNQMYLY HLGCHNWVSQ
DVLGTSRHAR YPKQQGVFAH AAALRNGNTL FLVGGYHGNV NGDLLAYTLP PLLIVENEED
FEPEAACPKH TSVTECLSDP ECGWCSADNV CYGRTIGANC TTNLQTTRCR GICPALGDCH
SCLIHGSAAK GSSKSVSNKL GFDRCTWCVQ NARCHHNNDN YGVCGEDTPS QNPGWWGTKG
TEVLSPDQCT QKDTRPGLTF LKYLDPVNWS MPDSVMVVNA TMVDFNVPSS TTHAEQSFNG
QVVARLLGFI RPPAVWEGAG ERLRACASYS QAVLRMASTD LGTANSRKKV VPVVTANITA
GQTVCEMAQW RSLEPRFRVM VDFQAKRSTA VNIQSHHQQI SKMGLQHSAI GQENPKTFTF
EFLEPFSNGS CGSYANCLHC LSDSLCGWCE LTSQCISRQS NESITCRKGS NWRYLTVQPA
QCSNCSNYIS CEQCIQTGIC EWWAEDARCS RKGRSLTAVI ELDQCPIPCY LRTNCSTCLN
ERGRCVWCEA TNQCFSFSVY TSEYQFGLCR EWLDQTMPTP TTAGSQLVSP PVQQCKSCSS
HRNCSQCLRS LSCGWCYDVD NPIEGICMQG DFNRSTYNCP ETLNTTSEKA RWSYAQCPDV
DECELGLHDC HEQAECSNTH GSFSCRCRKG FLGDGVRNCI QTCYETCVHG YCSGGPDYRC
QCDLGWTGID CSQNCECNNH STCVQGVGKC DKCMNWTEGQ YCERCSPGSF GNATSELGCQ
PCDCNGHGNE ALGICDSQTG ECYCQDNTEG LKCEMCNRNF FGDPKGGGQC YYQCEPRGVL
TNVGTEGIGS YQSHRSIRGG TEARECLWII SPYVKHGGEL KNAIIQFEIE PQDMNVTCGQ
NAVYVYDGLP DLTGATQQKQ LLAVFCSEDK SPWVTEARSG HLTIHYKQGG HGQGFKAIYN
VMSCSINTCK RPYVCHADKC VCPKGFAGPR CSLKICPSDC NVDRKQGTCD IGYGRCICAA
GYGGPDCSRT IKPSNIVFME LFNSYLISDS FEHLRKTLPR FGHSLVADRR GSLWMFGGYS
LSHGPLNDIR QFDTKNNTWM QVTVDSSPED RMPQGRYFHA AEIIFSKQAI YIYGGLSRNQ
SSHLVLDDFW QFGLQTQRWS MVTQNGAKPP PLAGHTMTVV KEADKDVLLI IGGFSVDNGM
QNRIWMFDLS SNSWSKLLTT GAKPTGIFGH STVCHPTKQI LYLYGGIVFT DGKSKVSNKL
YAFNFKNLKW TELPAFASKP SDYVPQTRYL HSAVTTENYM LVFGGRSHPG SVGDTMIAYV
YKCNRWLRLG ADIEIIGNTF GQTYAQAMTQ DPDYDAFYSV GGWDGSSYSR VTKIIMPPDL
CDLWSSSKYH CRQYMGCSYC AITTMEGSKT HCYSVGNSDV CDAQNGTLSF NNGAPCDDEW
ISKRNCSLFD TCSTCLASFP SHVESNPVCQ WCPECGVRGK CLQYDSDCTA ENKCQFNHST
IIELDSCPAF NCASSDCESC HAMSNCSWTF TGKHFQCQFR NETDSNKKPA ACPPNCHTYT
SCSACLSQPS SEGGFADCRW STQLNECISP SYQPIYCAGS ICGLVLDPSN IEQCPEPCGA
FSQCATCLRH AHCGWCSRNG TEGDGVCTEG SLDSPVDYPA ASTCDVIYSV KNNITVIDRN
DRFSWNYVKC PPENECANSH HSCNVKSERC VDRPHGYECQ CADGYKSDSG VCVPVCRQGC
VRGLCTEPDK CECDFGYVGA NCSIQCQCNG HSNCAGPDQL DSCLHCHNNT LGSQCEKCMP
FFVRDPRSNG ECIPCSEYCY GHTDLCVSKE LEPIVKNMTR IELNNYLTEG SQSDAVCLRC
ENFTDGDRCD TCIPGYFRGA TIASDSCRPC QCHGHGDMCD PVTGEKCNCG NNTESDNTCS
AKGKNLAYSC WSMQCTKCKD SYSGHPSNGH QCYKHITVDS RMCFDAKTID ECKIKPQPLK
SGQTVFFVIQ PRYMNVDIRF IVDVTQGELD FYMSPNDESF VVHSNGSSGH HDIFLDNRYS
WQHDIVDVTS VDTLNLYPLN IHGNSSDINI DPSMPIGLAS SQSNCRMDTE KFFFVKDRIA
KDLITYVTLY QCNSLLRVFG LKNRLVVTLP HTIHSLGQTK FYIALRARTG STASYGLVFF
RQDQLHIHLF VFFSVFFSCF FLFLAICVLA WKAKQAADMR RARIRHVVEM LHMAKRPFGR
INLSLDSPGE TPASHRKRVR SKHHAAQQLQ QDIAPVALEP TADNVAAVGT VFVRLPGKQK
SQITLALASS LVVLTRSHTT YNRAFHRRRG SSHHHNQHAQ IMQQHLQEEP VFVDLAQEQL
PLQPMALQRP LERNN
//
