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Database: UniProt
Entry: Q16HE2_AEDAE
LinkDB: Q16HE2_AEDAE
Original site: Q16HE2_AEDAE 
ID   Q16HE2_AEDAE            Unreviewed;       831 AA.
AC   Q16HE2;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   27-SEP-2017, entry version 68.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=5579216 {ECO:0000313|VectorBase:AAEL014053-PA};
GN   ORFNames=AAEL014053 {ECO:0000313|EMBL:EAT33671.1};
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT33671.1, ECO:0000313|Proteomes:UP000008820};
RN   [1] {ECO:0000313|EMBL:EAT33671.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT33671.1};
RA   Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA   Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA   Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G.,
RA   Utterback T., Rogers Y.-H., Kravitz S., Fraser C.M.;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EAT33671.1, ECO:0000313|Proteomes:UP000008820, ECO:0000313|VectorBase:AAEL014053-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT33671.1}, and Liverpool/LVPib12
RC   {ECO:0000313|Proteomes:UP000008820,
RC   ECO:0000313|VectorBase:AAEL014053-PA};
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M.,
RA   Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J.,
RA   Sinkins S.P., Hogenkamp D.G., Amedeo P., Arensburger P.,
RA   Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V.,
RA   Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B.,
RA   DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M.,
RA   Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H.,
RA   Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S.,
RA   Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D.,
RA   Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A.,
RA   Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D.,
RA   White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A.,
RA   Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J.,
RA   Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B.,
RA   Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
RN   [3] {ECO:0000313|EMBL:EAT33671.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT33671.1};
RG   VectorBase;
RL   Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|VectorBase:AAEL014053-PA}
RP   IDENTIFICATION.
RC   STRAIN=Liverpool/LVPib12 {ECO:0000313|VectorBase:AAEL014053-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; CH478180; EAT33671.1; -; Genomic_DNA.
DR   RefSeq; XP_001657344.1; XM_001657294.1.
DR   UniGene; Aae.3482; -.
DR   ProteinModelPortal; Q16HE2; -.
DR   STRING; 7159.AAEL014053-PA; -.
DR   PRIDE; Q16HE2; -.
DR   EnsemblMetazoa; AAEL014053-RA; AAEL014053-PA; AAEL014053.
DR   KEGG; aag:AaeL_AAEL014053; -.
DR   VectorBase; AAEL014053-RA; AAEL014053-PA; AAEL014053.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   HOGENOM; HOG000037059; -.
DR   InParanoid; Q16HE2; -.
DR   KO; K02154; -.
DR   OMA; FILRANH; -.
DR   OrthoDB; EOG091G01BI; -.
DR   PhylomeDB; Q16HE2; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008820};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008820};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    395    424       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    444    466       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    535    553       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    568    591       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    640    662       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    765    786       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       95    122       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   831 AA;  94917 MW;  4629DD74F49DE526 CRC64;
     MGAMFRSEEM ALCQMFIQPE AAYTSVSELG ETGAVQFRDL NSEVNAFQRK FVSEVRRCDE
     MERKLRYVEA EVKKDNVKIP DIRDELPRAP NPREIIDLEA HLEKTESEIL ELSQNAVNLK
     SNYLELTELK HVLERTQGFF FEQEGAVNLD ATRNNLIIDD HTNVQARGRL GFVAGVIQRE
     KVPGFERMLW RISRGNVFLR QVELEKPLED PATGNEIYKT VFAAFFQGEQ LKTRIKKVCT
     GYHASLYPCP SAADEREEMV KGVRTRLEDL NMVLNQTQDH RSRVLSTVAK ELPRWRIMVK
     KMKAIYHTLN LFNMDVTKKC LIGECWVPVL DLPIVQKALS DGSAAVGSTI PSFLNVIETS
     EQPPTFNRTN KFTRGFQNLI DSYGIASYRE ANPALYTIIT FPFLFGIMFG DLGHGLIMAL
     FGFWMVCGEK KLGAKRSTNE IWNIFFGGRY IIFLMGLFSM YTGFVYNDVF SKSMNIFGSS
     WSIGHNTSTI MTNKDLTLNP GSSDLDDNVY PIGLDPVWQL ASNKIIFLNS YKMKLSIIFG
     VVHMIFGVCM SVVNHNFFKK RISILLEFLP QIIFLVLLFA YMVFMMFMKW IQYTAKTDYQ
     PNTPGCAPSV LIMFINMMLF KRTPPLHGCD EYMYSFQGSL QRTFVFIALI CVPWMLLGKP
     LYIMFNKKKM AAAHHNGGIN QQTETALEPA ESAKASGHGG HEDEPISEVF IHQAIHTIEY
     VLSTVSHTAS YLRLWALSLA HAQLSEVLWN MVLSMGLRQS SYKGAIMLYF VFGAWALFTL
     AILVMMEGLS AFLHTLRLHW VEFMSKFYEG LGYVFQPFSF KLILDADDDF E
//
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