ID Q16KH8_AEDAE Unreviewed; 810 AA.
AC Q16KH8;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 121.
DE RecName: Full=General transcription and DNA repair factor IIH helicase subunit XPB {ECO:0000256|ARBA:ARBA00014343};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=5577460 {ECO:0000313|EnsemblMetazoa:AAEL013205-PA};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EnsemblMetazoa:AAEL013205-PA, ECO:0000313|Proteomes:UP000008820};
RN [1] {ECO:0000313|EnsemblMetazoa:AAEL013205-PA, ECO:0000313|Proteomes:UP000008820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL013205-PA,
RC ECO:0000313|Proteomes:UP000008820};
RG Aedes aegypti Genome Working Group (AGWG);
RA Matthews B.J.;
RT "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AAEL013205-PA}
RP IDENTIFICATION.
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL013205-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR RefSeq; XP_001663182.1; XM_001663132.1.
DR AlphaFoldDB; Q16KH8; -.
DR STRING; 7159.Q16KH8; -.
DR PaxDb; 7159-AAEL012991-PA; -.
DR EnsemblMetazoa; AAEL013205-RA; AAEL013205-PA; AAEL013205.
DR VEuPathDB; VectorBase:AAEL013205; -.
DR eggNOG; KOG1123; Eukaryota.
DR HOGENOM; CLU_008213_0_0_1; -.
DR InParanoid; Q16KH8; -.
DR OMA; RCQEIDY; -.
DR OrthoDB; 1360679at2759; -.
DR Proteomes; UP000008820; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd18029; DEXHc_XPB; 1.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001161; XPB/Ssl2.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR NCBIfam; TIGR00603; rad25; 1.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008820}.
SQ SEQUENCE 810 AA; 91871 MW; 5FFA99F451CFA6A1 CRC64;
MGPPKKSKKD RAGTGASSAT GGFVENKWNK KRRPEDEAYS AFANDDDDSN LDAAGGEFVP
EAASKNAEKI DEGIQEDEYG AKDYRSQMEL KPDNASRPLW VAPNGHIFLE SFSPVYKHAH
DFLIAISEPV CRPEHIHEYK LTAYSLYAAV SVGLQTHDII EYLKRLSKTT VPEGIQEFIR
LCTLSYGKVK LVLKHNKYFV ESPHPEVLQK LLKDPVIQSC RLRRTNDEGD GFITQTMEKK
AITAFGNTKI GPTTTVPATT EVEKPAEAET AVAVPDDITN FYDKMDNEEE EEEANLNTVS
FEVNQEKIEV LQKRCIEIEF PLLAEYDFRN DTINADINID LKPAAVLRPY QEKSLRKMFG
NGRARSGVIV LPCGAGKSLV GVTACCTVRK RALVLCNSGV SVEQWKQQFK MWSTADDSMI
CRFTSEAKDK PMGCGILVTT YSMITHTQKR SWEAEQTMRW LQEQEWGIMV LDEVHTIPAK
MFRRVLTIVQ SHCKLGLTAT LLREDDKIAD LNFLIGPKLY EANWLELQKR GYIARVQCAE
VWCPMAPEFY REYLVAKTSK KMLLYVMNPA KFRACQYLIR YHEKRGDKTI VFSDNVFALK
HYAIKMNKPY IYGPTSQSER IQILQNFKFN PKVNTIFVSK VADTSFDLPE ANVLIQISSH
GGSRRQEAQR LGRILRAKKG AIAEEYNAFF YTLVSQDTLE MGYSRKRQRF LVNQGYSYKV
ITHLAGMDSD PDLFYKTREE QGQLLQQVLS ATDMDCEDER IPGEGTGAPR PGGSKRTGGL
SSMSGADDAV YLEFRKKKEH LHPLFKKFRG
//
