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Database: UniProt
Entry: Q16QL3
LinkDB: Q16QL3
Original site: Q16QL3 
ID   COQ2_AEDAE              Reviewed;         441 AA.
AC   Q16QL3;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   01-OCT-2014, entry version 50.
DE   RecName: Full=4-hydroxybenzoate polyprenyltransferase, mitochondrial;
DE            EC=2.5.1.39;
DE   AltName: Full=Coenzyme Q biosynthesis protein 2;
DE   AltName: Full=Para-hydroxybenzoate--polyprenyltransferase;
DE            Short=PHB:polyprenyltransferase;
DE   Flags: Precursor;
GN   Name=coq2 {ECO:0000250|UniProtKB:Q9VHS7}; ORFNames=AAEL011249;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1] {ECO:0000312|EMBL:EAT36680.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M.,
RA   Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J.,
RA   Sinkins S.P., Hogenkamp D.G., Amedeo P., Arensburger P.,
RA   Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V.,
RA   Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B.,
RA   DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M.,
RA   Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H.,
RA   Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S.,
RA   Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D.,
RA   Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A.,
RA   Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D.,
RA   White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A.,
RA   Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J.,
RA   Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B.,
RA   Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Catalyzes the prenylation of para-hydroxybenzoate (PHB)
CC       with an all-trans polyprenyl group. Mediates the second step in
CC       the final reaction sequence of coenzyme Q (CoQ) biosynthesis,
CC       which is the condensation of the polyisoprenoid side chain with
CC       PHB (By similarity). {ECO:0000250|UniProtKB:Q96H96}.
CC   -!- CATALYTIC ACTIVITY: A polyprenyl diphosphate + 4-hydroxybenzoate =
CC       diphosphate + a 4-hydroxy-3-polyprenylbenzoate.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC       {ECO:0000250|UniProtKB:Q96H96}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q96H96}.
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; CH477745; EAT36680.1; -; Genomic_DNA.
DR   RefSeq; XP_001661527.1; XM_001661477.1.
DR   UniGene; Aae.3876; -.
DR   STRING; 7159.AAEL011249-PA; -.
DR   EnsemblMetazoa; AAEL011249-RA; AAEL011249-PA; AAEL011249.
DR   GeneID; 5574610; -.
DR   KEGG; aag:AaeL_AAEL011249; -.
DR   VectorBase; AAEL011249; Aedes aegypti.
DR   eggNOG; COG0382; -.
DR   HOGENOM; HOG000003697; -.
DR   KO; K06125; -.
DR   OMA; CATKFIS; -.
DR   OrthoDB; EOG72VH75; -.
DR   PhylomeDB; Q16QL3; -.
DR   UniPathway; UPA00232; -.
DR   GO; GO:0005736; C:DNA-directed RNA polymerase I complex; ISS:UniProtKB.
DR   GO; GO:0005666; C:DNA-directed RNA polymerase III complex; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0002083; F:4-hydroxybenzoate decaprenyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0047293; F:4-hydroxybenzoate nonaprenyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008412; F:4-hydroxybenzoate octaprenyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006360; P:transcription from RNA polymerase I promoter; ISS:UniProtKB.
DR   GO; GO:0006383; P:transcription from RNA polymerase III promoter; ISS:UniProtKB.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; ISS:UniProtKB.
DR   InterPro; IPR006370; HB_polyprenyl-transferase.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   Pfam; PF01040; UbiA; 1.
DR   TIGRFAMs; TIGR01474; ubiA_proteo; 1.
DR   PROSITE; PS00943; UBIA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isoprene biosynthesis; Membrane; Mitochondrion;
KW   Reference proteome; Transferase; Transit peptide; Transmembrane;
KW   Transmembrane helix; Ubiquinone biosynthesis.
FT   TRANSIT       1     95       Mitochondrion. {ECO:0000255}.
FT   CHAIN        96    441       4-hydroxybenzoate polyprenyltransferase,
FT                                mitochondrial.
FT                                /FTId=PRO_0000307702.
FT   TRANSMEM    129    149       Helical. {ECO:0000255}.
FT   TRANSMEM    154    174       Helical. {ECO:0000255}.
FT   TRANSMEM    204    224       Helical. {ECO:0000255}.
FT   TRANSMEM    225    245       Helical. {ECO:0000255}.
FT   TRANSMEM    246    266       Helical. {ECO:0000255}.
FT   TRANSMEM    271    291       Helical. {ECO:0000255}.
FT   TRANSMEM    322    342       Helical. {ECO:0000255}.
FT   TRANSMEM    346    366       Helical. {ECO:0000255}.
FT   TRANSMEM    378    398       Helical. {ECO:0000255}.
FT   COMPBIAS    408    424       Ser-rich. {ECO:0000255}.
SQ   SEQUENCE   441 AA;  48432 MW;  D5735F88971A3992 CRC64;
     MLRKLTSNSS RWTTTHLGSL WQEVGGHPIR RGLILHHHCR PLAAVSSGVI LRQKEESRWS
     PNSGGKLANL RCWPEYRLHS ATKRRTLGEL VLRDYSSNNI SDKKPEPKSL LQSIVQNPYA
     RLMRIDRPIG SWLLFWPCGW SIALSAPAGC WPDLWTLTLF GAGAFIMRGA GCTINDMWDR
     DIDGKVARTR NRPLVAGELT SADAWFFLGA QLGVGLLILL ELNWYSIVLG ASSLGLVIIY
     PLMKRITHWP QLVLGMTFNW GALLGWSATQ GSVMWSACLP LYVAGVCWTI VYDTIYAHQD
     KVDDALLGIK STAIRFGDNT KLWLSGFSTA MIGGLVASGM VCEQTWPYYS AVGVISAHLA
     HQIYSLNIDN PTDCATKFIS NHQVGLILFL GIVLGTLYKG YSQRAGKSST TSSSSTSSSS
     SPSSGLLLAA TNHHQPARQA S
//
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