ID COQ2_AEDAE Reviewed; 441 AA.
AC Q16QL3;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 03-APR-2013, entry version 46.
DE RecName: Full=4-hydroxybenzoate polyprenyltransferase, mitochondrial;
DE EC=2.5.1.39;
DE AltName: Full=Coenzyme Q biosynthesis protein 2;
DE AltName: Full=Para-hydroxybenzoate--polyprenyltransferase;
DE Short=PHB:polyprenyltransferase;
DE Flags: Precursor;
GN Name=coq2; ORFNames=AAEL011249;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea;
OC Culicidae; Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M.,
RA Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J.,
RA Sinkins S.P., Hogenkamp D.G., Amedeo P., Arensburger P.,
RA Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V.,
RA Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B.,
RA DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M.,
RA Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H.,
RA Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S.,
RA Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D.,
RA Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A.,
RA Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D.,
RA White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A.,
RA Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J.,
RA Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B.,
RA Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
CC -!- FUNCTION: Catalyzes the prenylation of para-hydroxybenzoate (PHB)
CC with an all-trans polyprenyl group. Mediates the second step in
CC the final reaction sequence of coenzyme Q (CoQ) biosynthesis,
CC which is the condensation of the polyisoprenoid side chain with
CC PHB (By similarity).
CC -!- CATALYTIC ACTIVITY: A polyprenyl diphosphate + 4-hydroxybenzoate =
CC diphosphate + a 4-hydroxy-3-polyprenylbenzoate.
CC -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane; Multi-pass membrane
CC protein (By similarity).
CC -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
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DR EMBL; CH477745; EAT36680.1; -; Genomic_DNA.
DR RefSeq; XP_001661527.1; XM_001661477.1.
DR UniGene; Aae.3876; -.
DR STRING; 7159.AAEL011249-PA; -.
DR EnsemblMetazoa; AAEL011249-RA; AAEL011249-PA; AAEL011249.
DR GeneID; 5574610; -.
DR KEGG; aag:AaeL_AAEL011249; -.
DR VectorBase; AAEL011249; Aedes aegypti.
DR eggNOG; COG0382; -.
DR HOGENOM; HOG000003697; -.
DR KO; K06125; -.
DR OMA; CATKFIS; -.
DR OrthoDB; EOG4QZ62N; -.
DR PhylomeDB; Q16QL3; -.
DR UniPathway; UPA00232; -.
DR GO; GO:0005736; C:DNA-directed RNA polymerase I complex; ISS:UniProtKB.
DR GO; GO:0005666; C:DNA-directed RNA polymerase III complex; ISS:UniProtKB.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0002083; F:4-hydroxybenzoate decaprenyltransferase activity; IEA:EC.
DR GO; GO:0047293; F:4-hydroxybenzoate nonaprenyltransferase activity; IEA:EC.
DR GO; GO:0008412; F:4-hydroxybenzoate octaprenyltransferase activity; ISS:UniProtKB.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006360; P:transcription from RNA polymerase I promoter; ISS:UniProtKB.
DR GO; GO:0006383; P:transcription from RNA polymerase III promoter; ISS:UniProtKB.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; ISS:UniProtKB.
DR InterPro; IPR006370; HB_polyprenyl-transferase.
DR InterPro; IPR000537; UbiA_prenyltransferase.
DR Pfam; PF01040; UbiA; 1.
DR TIGRFAMs; TIGR01474; ubiA_proteo; 1.
DR PROSITE; PS00943; UBIA; 1.
PE 3: Inferred from homology;
KW Complete proteome; Isoprene biosynthesis; Membrane; Mitochondrion;
KW Reference proteome; Transferase; Transit peptide; Transmembrane;
KW Transmembrane helix; Ubiquinone biosynthesis.
FT TRANSIT 1 95 Mitochondrion (Potential).
FT CHAIN 96 441 4-hydroxybenzoate polyprenyltransferase,
FT mitochondrial.
FT /FTId=PRO_0000307702.
FT TRANSMEM 129 149 Helical; (Potential).
FT TRANSMEM 154 174 Helical; (Potential).
FT TRANSMEM 204 224 Helical; (Potential).
FT TRANSMEM 225 245 Helical; (Potential).
FT TRANSMEM 246 266 Helical; (Potential).
FT TRANSMEM 271 291 Helical; (Potential).
FT TRANSMEM 322 342 Helical; (Potential).
FT TRANSMEM 346 366 Helical; (Potential).
FT TRANSMEM 378 398 Helical; (Potential).
FT COMPBIAS 408 424 Ser-rich.
SQ SEQUENCE 441 AA; 48432 MW; D5735F88971A3992 CRC64;
MLRKLTSNSS RWTTTHLGSL WQEVGGHPIR RGLILHHHCR PLAAVSSGVI LRQKEESRWS
PNSGGKLANL RCWPEYRLHS ATKRRTLGEL VLRDYSSNNI SDKKPEPKSL LQSIVQNPYA
RLMRIDRPIG SWLLFWPCGW SIALSAPAGC WPDLWTLTLF GAGAFIMRGA GCTINDMWDR
DIDGKVARTR NRPLVAGELT SADAWFFLGA QLGVGLLILL ELNWYSIVLG ASSLGLVIIY
PLMKRITHWP QLVLGMTFNW GALLGWSATQ GSVMWSACLP LYVAGVCWTI VYDTIYAHQD
KVDDALLGIK STAIRFGDNT KLWLSGFSTA MIGGLVASGM VCEQTWPYYS AVGVISAHLA
HQIYSLNIDN PTDCATKFIS NHQVGLILFL GIVLGTLYKG YSQRAGKSST TSSSSTSSSS
SPSSGLLLAA TNHHQPARQA S
//
