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Database: UniProt
Entry: Q16VK8_AEDAE
LinkDB: Q16VK8_AEDAE
Original site: Q16VK8_AEDAE 
ID   Q16VK8_AEDAE            Unreviewed;       808 AA.
AC   Q16VK8;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   25-OCT-2017, entry version 75.
DE   SubName: Full=AAEL009529-PA {ECO:0000313|EMBL:EAT38588.1};
GN   Name=5572130 {ECO:0000313|VectorBase:AAEL009529-PA};
GN   ORFNames=AAEL009529 {ECO:0000313|EMBL:EAT38588.1};
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT38588.1, ECO:0000313|Proteomes:UP000008820};
RN   [1] {ECO:0000313|EMBL:EAT38588.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT38588.1};
RA   Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA   Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA   Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G.,
RA   Utterback T., Rogers Y.-H., Kravitz S., Fraser C.M.;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EAT38588.1, ECO:0000313|Proteomes:UP000008820, ECO:0000313|VectorBase:AAEL009529-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT38588.1}, and Liverpool/LVPib12
RC   {ECO:0000313|Proteomes:UP000008820,
RC   ECO:0000313|VectorBase:AAEL009529-PA};
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M.,
RA   Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J.,
RA   Sinkins S.P., Hogenkamp D.G., Amedeo P., Arensburger P.,
RA   Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V.,
RA   Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B.,
RA   DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M.,
RA   Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H.,
RA   Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S.,
RA   Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D.,
RA   Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A.,
RA   Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D.,
RA   White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A.,
RA   Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J.,
RA   Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B.,
RA   Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
RN   [3] {ECO:0000313|EMBL:EAT38588.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT38588.1};
RG   VectorBase;
RL   Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|VectorBase:AAEL009529-PA}
RP   IDENTIFICATION.
RC   STRAIN=Liverpool/LVPib12 {ECO:0000313|VectorBase:AAEL009529-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
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DR   EMBL; CH477589; EAT38588.1; -; Genomic_DNA.
DR   RefSeq; XP_001660195.1; XM_001660145.1.
DR   ProteinModelPortal; Q16VK8; -.
DR   STRING; 7159.AAEL009529-PA; -.
DR   EnsemblMetazoa; AAEL009529-RA; AAEL009529-PA; AAEL009529.
DR   KEGG; aag:AaeL_AAEL009529; -.
DR   VectorBase; AAEL009529-RA; AAEL009529-PA; AAEL009529.
DR   eggNOG; KOG0510; Eukaryota.
DR   eggNOG; COG0666; LUCA.
DR   HOGENOM; HOG000044673; -.
DR   InParanoid; Q16VK8; -.
DR   OMA; SFFENHS; -.
DR   OrthoDB; EOG091G025V; -.
DR   PhylomeDB; Q16VK8; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR030288; TRPA1/painless.
DR   PANTHER; PTHR24190; PTHR24190; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SUPFAM; SSF48403; SSF48403; 2.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|SAAS:SAAS00933366};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008820};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008820};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    359    375       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    387    404       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    424    441       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    448    466       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    486    505       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    554    576       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      199    241       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   COILED      733    760       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   808 AA;  93362 MW;  0AECCD61BB74BE36 CRC64;
     MMHMQGGANK QLCLGFYQEW VQIKVTVELL EILLRFKEEQ RFERKFLQFK VDEWNVREVI
     RLLLHIAVEL DMERSVKTII EHAGQLIFKT VKPITSKKKV LRVCEPDPEH DAKGSELVYR
     VELKGLLKKA CERGNVSTLT LLLGHITDRI LVNDDPILVF TLNRAQELWR HEEERAKVLQ
     CAEFLAKDQK IHLTRTDNNG NTALHTSLKF GFTDIALDLL QQKYAFLGVR NKDNQTPLDF
     ARFEFWKMYF DQCVAIDVRR SYFDRNEIRL NLNGFDPFIF KKRPTKKTSP KDRSEMNLWR
     IVEKASSSNV SHQQPQQTYV TEMDPVKIIA KSKELKRLLL HPVIYTFILV KWLRLTKWIY
     LNLICTLATV VCFGLHSLDT CNGDNQYSIA LNVITWIGAI YMIGREMVQI LFLRLSYFSS
     FENYLDIGTI ISMIIVLLNG CRSILSSLIV IAFALQLTVL IGSLPFNTLS TYMYMFKTVS
     ANFMKSFLLF IPLLGAFTFS FFLSYNDRTV PHNSTEDEIP FNTFSSFTDA ALKTLVMTTG
     EYEAAGVDFS GGKIILFVLF IFFAPIVILN LINGLAVSDI TAIKEESELI SLRKKVLILE
     RYERGLREMP IEFIRRMFPS SFFENHSYII IVKPKELRKI LVQHINPQAE NQRGQKLPKG
     EWRVVPNMPG GWLVRGSEGF FVNLKFLKFP LFCTLDEHIM DEALQIADAS IMLREIMDSR
     RAEMTSMASM SSFTDTEDKL EEMKAEITKM NRLLMRALQQ KQPTKRKISG NKAKMVREID
     EPGDKFTTVT KVAKAVGKFK KGKKKPKS
//
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