ID Q174B8_AEDAE Unreviewed; 491 AA.
AC Q174B8;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 24-JAN-2024, entry version 101.
DE SubName: Full=AAEL006960-PA {ECO:0000313|EMBL:EAT41407.1};
GN ORFNames=AAEL006960 {ECO:0000313|EMBL:EAT41407.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT41407.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT41407.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT41407.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT41407.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT41407.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT41407.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT41407.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00239}.
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DR EMBL; CH477414; EAT41407.1; -; Genomic_DNA.
DR RefSeq; XP_001652363.1; XM_001652313.1.
DR AlphaFoldDB; Q174B8; -.
DR STRING; 7159.Q174B8; -.
DR MEROPS; C02.010; -.
DR PaxDb; 7159-AAEL018127-PA; -.
DR GeneID; 5568545; -.
DR KEGG; aag:5568545; -.
DR VEuPathDB; VectorBase:AAEL018127; -.
DR eggNOG; KOG0045; Eukaryota.
DR HOGENOM; CLU_003001_3_1_1; -.
DR OMA; INATEYH; -.
DR OrthoDB; 142935at2759; -.
DR PhylomeDB; Q174B8; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00044; CysPc; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF382; CALPAIN-15; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00230; CysPc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
PE 3: Inferred from homology;
FT DOMAIN 1..218
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT ACT_SITE 142
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1"
FT ACT_SITE 162
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1"
SQ SEQUENCE 491 AA; 55402 MW; 94F88DCEFDE46A2E CRC64;
MCPQGAYQVR LCKDGKWTTV LVDDLLPCDK KGHLVYSQAK RKQLWVPIIE KAVAKIHGCY
EALVSGRAIE GLATLTGAPC ESIPLQPSSI PLPSEDDLDR DLIWAQLLSS RLVKFLMGAS
CGGGNMKVDE DEYQRKGLRP RHAYSVLDVR DIQGNRLLKL RNPWGHYSWQ GDWSDDSPLW
TEELRDVLMP HGGSEGVFWI SFEDVLKYFD CIDICKVRSN WNEVRLLGTL QPLCALSCVL
LTVLEPTEAE FTLFQEGQRN SEKSQRSQLD LCVVVFRTRN PAKPEVGRLV EHSKRQVRGF
VGCHKMLERD LYLLVCLAFN HWHTGIDDPS LYPQCVLAIH SSKKLLVEQI TPPPYLLADA
IISLTLTKGQ RHEGREGMTA YYLTKGWAGL VVMVENRHEN KWIHVKCDCQ ESYNVVSTRG
ELKTIDSVPP LQRQVIIVLT QLEGSGGFSI AHRLTHRLAN SSGLHDWGPP SATHCPPIDN
VYDLHSPRLI T
//
