ID Q177S0_AEDAE Unreviewed; 1894 AA.
AC Q177S0;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 123.
DE SubName: Full=AAEL006022-PA {ECO:0000313|EMBL:EAT42448.1};
DE Flags: Fragment;
GN ORFNames=AAEL006022 {ECO:0000313|EMBL:EAT42448.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT42448.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT42448.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT42448.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT42448.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT42448.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT42448.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT42448.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR EMBL; CH477371; EAT42448.1; -; Genomic_DNA.
DR RefSeq; XP_001657392.1; XM_001657342.1.
DR STRING; 7159.Q177S0; -.
DR PaxDb; 7159-AAEL006022-PA; -.
DR VEuPathDB; VectorBase:AAEL006022; -.
DR eggNOG; KOG1090; Eukaryota.
DR HOGENOM; CLU_002298_1_1_1; -.
DR OMA; FQHWEVV; -.
DR PhylomeDB; Q177S0; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd13208; PH-GRAM_MTMR5_MTMR13; 1.
DR CDD; cd14534; PTP-MTMR5-like; 1.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR022096; SBF1/SBF2.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF109; SET DOMAIN BINDING FACTOR, ISOFORM A; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF12335; SBF2; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1..428
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 1061..1581
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT DOMAIN 1713..1763
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 1811..1894
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 725..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1028..1052
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1894
FT /evidence="ECO:0000313|EMBL:EAT42448.1"
SQ SEQUENCE 1894 AA; 214623 MW; B7590160E721B474 CRC64;
GKILQRFPEK DWADTPFIEG IEWFCQPQGW SLSTVRQEPQ FFVSVLTDID ANRHYCACLC
FNETIAITPS KPIDEEEEDD NLSPSSRALL AASSGPPSIT HHSIMYAPKC LVIVSRLDYI
ETFRNCLGTI YTVYLESLKF HLHHLIGSIL GCIQVPPPGG PQVRFSIGAG DKQVLQPPIS
PTIPVTGSCV SLLFHQLGIK NVMLLFCAVM TEHKILFHST SYSRLTDSCR ALTALMYPFR
YSHVYIPILP ASLVEVLSTP TPFIMGIHSS MQTEVTEVLD VIIADLDGGS IHIPQSLVPP
PAELPKALRE ATEIALQQVL HPELTRADLA FPPNNINNNG YNFREQKSDE MLDKEIRAVF
MRLFAQLLQG YRSCLTLIRI NPKPIIQFHR AGFLGARDLV DCDFLSRVLD SMFFTGFVTE
RGPPWRPCDA WDELYSAMND LLKQEMQDPH LVLIHIQELA KQLYTNENPS PQPYQQKVLR
PPEGAFARIH QPPMPLIDSQ EVQVNNSARK LEVLKNCISC IFDNKITEAR KSFPAVLRIL
KQRDARLTLC RELAKIAHGN KQLDHQQFDL VVKLMNRALQ DDSSKDEYGV AAALLPLSTT
FCRKLCTGVI QFAYTCIQDH PVWKNQQFWE DAFYHDVQNF IKELYLPRQT SEKSYSSWAT
DTNAQEPSAL EIAADQMRIW PTVDLDKQTE LTSSEEKTLY SQAIHYANRM VFLLIPQDVN
QGGRVQKLDS HADDDASVSN SVIESHSHSD HSDEGFEDND PSEVGSQVAK MVCKFIDRVC
NEGNVTPEHL RNLHQMVPGV IQMHIETLES VNREAKRIPP IQKPKLQFPN FLQGEELIGD
PMRVYLLADG REEKEVGTSN LLPAEGALYL TNYRIVFKGS PCDPYCCEQS VVRAFPISSL
TKEKRLTVIY LQHLEQVLQE GMQLRSCTFQ LIKVAFDEEV IADAIEAFRK TIHRVRHPED
EFGHFAFATT HGITNPTPLH KVKEKNATLK DFAKKTLLRT AKKAGFKQKS TTKRKYILPG
ADFEETYGNS SMGINENPED EDGSDDGADT MPRVTVKDVE RLKERSYVKD WLRVGLGDVQ
AGYRISSINC NYSLCRTYPA MLVCPKDVSD DSLRNLSRCY KHHRIPVATW RHKNGATLLR
GAVPLAKGVM GMLKGHPGSS NNSADSASFH EQDRYFVCVI KTTPHTRPIR HTGNFSDSNL
SLDSLALAAN GLMTRTDNST LTPDIGRKNN VGLYSINNSS FSSFGALRPT PKQNKWGSWD
HQPQQYTIQR VPLYFLGEKS QSKSAKLSEM YAEFIPVDYT DVRHSRTAFK KLMRACLPSC
LNTEPDQTFS KLVEQSEWLQ QIRGLLQLSG AVVDLMDLQE SSVTLALEDG WDVTAQISSL
AQLCLDPYYR TIDGFRVLIE KEWLAFGHRF GHRSNLKPNS SSGSPFAPTF LQFLDAVHQI
QSQFPLAFEF NEYYLRFLAY HHVSCRFRTF LFDCELERVD YGITAIDDKR GSLNSHHKHV
VEALTVSDDD NIYPGGLGGG VGRGNHASNT QKFGPSLFDY IERQHAKNPS FYNFMYTPDP
DRQVLRPQSS ISVLEVWSYY LDEELAQGPQ LLNNDNLDED SDYGSAGSMA NKHPRRKVVS
VGYDSLNKYD ADAFSRLIEE LKNAEAERGL LPQKWRQVWD KLELPHSDSL TRHASFSSAL
VRSHGRLLHK RSTLEIIMRG RQVGYHQENF LHPHRFEKHA YSAPINCNHC GNVLWGPLLN
GLRCVDCGNT YHEKCAESVP KNCTKYKAVE GTQPTLARNQ GDNNSVSSSV NTANTTSQHY
YEQYSSNVAD DRTHEGYLYK RGAILKNWKQ RWFVLDSHKH QLRYYDAMED CNCKGYIELA
EVQSVAQAPP QAAPVPSKKI DEKAFFDVSR KYFY
//
