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Database: UniProt
Entry: Q177V2_AEDAE
LinkDB: Q177V2_AEDAE
Original site: Q177V2_AEDAE 
ID   Q177V2_AEDAE            Unreviewed;      1835 AA.
AC   Q177V2;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   27-SEP-2017, entry version 83.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=AAEL006019 {ECO:0000313|EMBL:EAT42417.1};
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT42417.1, ECO:0000313|Proteomes:UP000008820};
RN   [1] {ECO:0000313|EMBL:EAT42417.1, ECO:0000313|Proteomes:UP000008820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Liverpool/LVPib12 {ECO:0000313|Proteomes:UP000008820};
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M.,
RA   Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J.,
RA   Sinkins S.P., Hogenkamp D.G., Amedeo P., Arensburger P.,
RA   Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V.,
RA   Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B.,
RA   DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M.,
RA   Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H.,
RA   Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S.,
RA   Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D.,
RA   Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A.,
RA   Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D.,
RA   White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A.,
RA   Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J.,
RA   Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B.,
RA   Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; CH477371; EAT42417.1; -; Genomic_DNA.
DR   RefSeq; XP_001657361.1; XM_001657311.1.
DR   UniGene; Aae.5786; -.
DR   ProteinModelPortal; Q177V2; -.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   HOGENOM; HOG000231755; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008820};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008820};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     46     69       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    177    199       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    540    563       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    584    601       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    613    637       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    668    690       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    748    769       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1048   1070       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1076   1102       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1123   1154       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1241   1267       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1330   1348       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1360   1379       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1391   1410       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1454   1477       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1547   1567       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1584   1619       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      203    238       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1835 AA;  205530 MW;  FE6D1B0FCF87C465 CRC64;
     MGIDLGNLAA LRTFRVLRAL KTVAIVPGLK TIVGAVIESV KNLRDVIILT MFSLSVFALM
     GLQIYMGVLT QKCIREFPMD GSWGNLSDEN WERFNNNDSN WYFSETGDTP LCGNSSGAGQ
     CEEGYICLQG YGDNPNYGYT SFDTFGWAFL SAFRLMTQDY WENLYQLVLR SAGPWHMLFF
     IVIIFLGSFY LVNLILAIVA MSYDELQKKA EEEEAAEEEA LREAEEAAAA KAAKLEAQAA
     AAAAAANPEI AKSPSDFSCH SYELFVNQEK GNDDNNKEKM SIRSEGLESV SEITRTTAPT
     ATAAGTAKAR KVSAFTIRNG RGRFVGVPGS DRKPLVLSTY LDAQEHLPYA DDSNAVTPMS
     EENGAIIVPV YYANLGSRHS SYTSHQSRIS YTSHGDLLGG MTKESRLRNR SARNTNHSIV
     PPPNMSGPNM SYVDSNHKGQ RDFDMSQDCT DEAGKIKHND NPFIEPSQTQ TVVDMKDVMV
     LNDIIEQAAG RHSRASDHGE DDDEDGPTFK DKALEFTMRM IDVFCVWDCC WVWLKFQEWV
     AFIVFDPFVE LFITLCIVVN TLFMALDHHD MDPDMERALK SGNYFFTATF AIEATMKLIA
     MSPKYYFQEG WNIFDFIIVA LSLLELGLEG VQGLSVLRSF RLLRVFKLAK SWPTLNLLIS
     IMGRTMGALG NLTFVLCIII FIFAVMGMQL FGKNYIDNVD RFPDKDLPRW NFTDFMHSFM
     IVFRVLCGEW IESMWDCMLV GDVSCIPFFL ATVVIGNLVV LNLFLALLLS NFGSSSLSAP
     TADNETNKIA EAFNRISRFS NWIKSNIANA LKFVKNKLTS QIASVQPAEH GENELELTPD
     DILADGLLKK GVKEHNQLEV AIGDGMEFTI HGDLKNKGKK NKQLMNNSKD DDTASIKSYG
     SHKNRPFKDE SHKGSAETME GEEKRDVSKE DLGIDEELDD ECDGEEGPLD GELIIHADED
     EVIEDSPADC CPDNCYKKFP VLAGDDDAPF WQGWANLRLK TFQLIENKYF ETAVITMILL
     SSLALALEDV HLPHRPILQD VLYYMDRIFT VIFFLEMLIK WLALGFRVYF TNAWCWLDFI
     IVMVSLINFV ASLCGAGGIQ AFKTMRTLRA LRPLRAMSRM QGMRVVVNAL VQAIPSIFNV
     LLVCLIFWLI FAIMGVQLFA GKYFKCVDKN KTTLSHEIIP DVNACVAENY TWENSPMNFD
     HVGKAYLCLF QVATFKGWIQ IMNDAIDSRE VGKQPIRETN IYMYLYFVFF IIFGSFFTLN
     LFIGVIIDNF NEQKKKAGGS LEMFMTEDQK KYYNAMKKMG SKKPLKAIPR PRWRPQAIVF
     EIVTNKKFDM IIMLFIGFNM LTMTLDHYKQ TDTFSAVLDY LNMIFICIFS SECLMKIFAL
     RYHYFIEPWN LFDFVVVILS ILGLVLSDLI EKYFVSPTLL RVVRVAKVGR VLRLVKGAKG
     IRTLLFALAM SLPALFNICL LLFLVMFIFA IFGMSFFMHV KDKSGLDDVY NFKTFGQSMI
     LLFQMSTSAG WDGVLDGIIN EDECLPPDND KGYPGNCGSA TIGITYLLAY LVISFLIVIN
     MYIAVILENY SQATEDVQEG LTDDDYDMYY EIWQQFDPDG TQYIRYDQLS DFLDVLEPPL
     QIHKPNKYKI ISMDIPICRG DMMFCVDILD ALTKDFFARK GNPIEETAEL GEVQARPDEV
     GYEPVSSTLW RQREEYCARV IQHAWRKHKE RQAGGGGGDD TDADACDNDD GDDGGGGAGD
     GGSAGGGGVT SPGVGSGSIV GGGTTPGSGG GGSQANLGIV VEHNLSPKES PDGNNDPQGR
     QTAVLVESDG FVTKNGHRVV IHSRSPSITS RSADV
//
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