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Database: UniProt
Entry: Q17EB5_AEDAE
LinkDB: Q17EB5_AEDAE
Original site: Q17EB5_AEDAE 
ID   Q17EB5_AEDAE            Unreviewed;      5118 AA.
AC   Q17EB5;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   25-OCT-2017, entry version 97.
DE   SubName: Full=AAEL003837-PA {ECO:0000313|EMBL:EAT44864.1};
GN   ORFNames=AAEL003837 {ECO:0000313|EMBL:EAT44864.1};
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT44864.1, ECO:0000313|Proteomes:UP000008820};
RN   [1] {ECO:0000313|EMBL:EAT44864.1, ECO:0000313|Proteomes:UP000008820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Liverpool/LVPib12 {ECO:0000313|Proteomes:UP000008820};
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M.,
RA   Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J.,
RA   Sinkins S.P., Hogenkamp D.G., Amedeo P., Arensburger P.,
RA   Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V.,
RA   Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B.,
RA   DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M.,
RA   Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H.,
RA   Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S.,
RA   Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D.,
RA   Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A.,
RA   Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D.,
RA   White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A.,
RA   Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J.,
RA   Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B.,
RA   Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
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DR   EMBL; CH477283; EAT44864.1; -; Genomic_DNA.
DR   RefSeq; XP_001657320.1; XM_001657270.1.
DR   UniGene; Aae.11179; -.
DR   ProteinModelPortal; Q17EB5; -.
DR   STRING; 7159.AAEL003837-PA; -.
DR   PRIDE; Q17EB5; -.
DR   EnsemblMetazoa; AAEL003837-RA; AAEL003837-PA; AAEL003837.
DR   GeneID; 5579122; -.
DR   KEGG; aag:AaeL_AAEL003837; -.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   HOGENOM; HOG000231428; -.
DR   InParanoid; Q17EB5; -.
DR   KO; K04962; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   PhylomeDB; Q17EB5; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008820};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008820};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4445   4465       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4631   4652       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4726   4745       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4856   4877       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4915   4935       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4991   5014       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       94    148       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      155    200       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      210    264       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      270    318       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      336    396       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      577    803       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1032   1218       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1438   1656       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     4584   4606       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5118 AA;  578550 MW;  976FA82ACF285122 CRC64;
     MAEAEGGSEQ DDVSFLRTED MVCLSCTATG ERVCLAAEGF GNRHCFLENI ADKNIPPDLS
     QCVFVIEQAL SVRALQELVT AAGSETGKGT GSGHRTLLYG NAILLRHNNS DMYLACLSTS
     SSNDKLSFDV GLQEHSQGEA CWWTVHPASK QRSEGEKVRV GDDLILVSVA TERYLHTTKE
     NDLSIVNASF HVTHWSVQPY GTGISRMKYV GYVFGGDVLR FFHGGDECLT IPSTWGQEPG
     QNMVVYEGGS VMSQARSLWR LELARTKWAG GFINWSHPMR IRHLTTGRYL GVNENNELIL
     MSRELATTSQ TAFVLRAEKD DQKVVLEDKD LEVIGAPIIK YGDSTVIMQH HESGLWVSYK
     SYETKKKGVG KVEEKQAVLH EEGKMDDGLD FSRSQEEESR TARVIRKCSH LFTKFIGGLE
     TLQQNRRHSF FLQTINLGEM VMCLEDLINY FAQPEDDMEH EERQNRLRAL RNRQDLFQEE
     GVLNLILEAI DKINVISSQG FLASFLASDE TGQSWEMISG YLYQLLAAII KGNHTNCAQF
     ANSNRLNWLF SRLGSQASSE GSGMLDVLHC VLIDSPEALN MMRDEHIKVI ISLLEKHGRD
     PKVLDVLCSL CVGNGVAVRS SQNNICDFLL PGKNLLLQTS LVDHVASVRP NIFVGRVEGS
     AVYQKWYFEV TMDHIEQTTH MSPHLRIGWA NTNGYVPYPG GGEKWGGNGV GDDLFSYGFD
     GVFFWSAGRR TQVVFSDISE PFIKKNDVIG CTLDLSVPVI RFTFNGEPVH GCFTDFNLDG
     MFFPVISCSS KLSCRFLFGG DHGRMKFNPP PGFSPLVQCL MPHQNLSLDP CFFFGNLNKN
     VLAGPWLVED DSAFVPKPVD TSSVTLPSSV ETIKDKLAEN IHEMWALNKI EAGWTWGERR
     DDLYRIHPCL TSFEKLPAAE KRYDCQLAVQ TLKTILSLGY YISMDKPPAR IRPIRLPNDP
     YMQGNGYKPA PLDLSAAVLN PKMEELIDLL AENTHNLWAK ERIQQGWTYG LNEDGENRRS
     PHLVPYSKVD EAIKKANRDT ASETVRTLLI YGYNLDPPTG EANEALAAEA FRQKFSAFRT
     YRAEKNYAVT SGKWYFEFEV LTAGPMRVGW ARADCNPGTM LGSDDSSWAF DGYNARKLHL
     HTVEDFGRRY QVGDIIGCLI NVTDKTTSFS LNGELLMDAL GGETTFADVT APEGVGFVPA
     CTIGIGQKAR VVYGQDVDSL KWFTTCGLQE GYEPFCVNMK RAVTHWYTKD QPIFENNEDI
     PDCKIDVTRI PGGADTPPCL KISHNTFETM EKANWEFLRL SLPVTCDASF IDESEKMHRW
     EEIRIRQHRL LMEAEHQAQP SGAHMDHIMK SGFTMNDLKG LQRNYSEDGV ESDEVMRHGP
     QRPTRASRRA EALSPPGIEI NGEMHMSDPE NAYSDHEMED DRKKRGRSPF RLFGKKRDQS
     KDKLKDQRMP EPEPRKGTMQ QRTVARSPTM RASNADVRGA AQMAAERKSM GSPQGVESFG
     NEVYDADCLK LINEYFYGVR IFPGQDPTHV YVGWVTTQYH VHSKEFNQDK VRHAAIYVED
     EGETTVEVVN RQSCYMVRAD ELFNEVTQDA SGKGASQGMF VGCFVDTATG TIRFTCEGKE
     TSHVFLMEPE TKLFPAIFVE ATSKEILQIE LGRTPTTLPL SAAVLPTGDK HINPQFPPRL
     KVQCLKPHQW ARVPNTALQV HALKLSDIRG WSMLCEDPVS MLALHIPEED RCIDILELIE
     MDRLLSFHAH TLTLYSALCY QSNYRAAHAL CNHVDQKQLL YAIQSEYMSG PLRLGFYDLL
     IALHLESHAN TMEVCKNEFI IPLGPELKDL YVDPEMCHSL RSLQTLSVRP QMNMTEIASP
     SPPQSNLPTI VAPDSSSEPI PAIDSLYSPR FPLEVVREFV MAALKEAVEI NQVHNRDPIG
     GSNENLFLPL IKLIDRLLLV GVITNEDVEK LLIMIDPETW DPLFEKEGKD EHRKGLLTMK
     MAEGAKLQMC YLLHHLYDVQ LRHRTESIIA FAHDYVCDLQ QDQLRRYIEI KQSDLPSAVA
     AKKTREFRCP PREQMNAILC FKNLEGEDLE NCSCGSELRE RLIEFHEKLM GKVSLNALQE
     PEEESAEPVD ESKPGALKKL YNFINAVKEL EEDPKEPEEV ERKTPEEVFR KVLIKQIVSW
     AEESQIENPK LVREMFGLLV RQYDTIGELI NALNKTYVIN SKTTGDVANM WVGLSQIRAL
     LPVQMSQEEE ELMRKRLWKL VNNHTFFQHP DLIRILRVHE NVMAVMMNTL GRRAQAQSDA
     PVQSAEGEEA QPKEKDTSHQ MVVACCRFLC YFCRTGRQNQ RAMFDHFDFL LENSNILLSR
     PSLRGSTPLD VAYSSLMENT ELALALREHY LEKIAVYLSR CGLQSNSELI ERGYPDLGWD
     PVEGERYLDF LRFCVWVNGE SVEENANLVI RLLIRRPECL GPALRGEGEG LLKAIIDANK
     MSEKIAERRK MQDEAEGTIA GLGFSHPLPE GDDDEDYIDT GAAILCFYCT LVDLLGRCAP
     DASVIEQGKN ESLRARAILR SLVPLEDLQG VLGLKFTLTN PAAGEERPKS DMPSGLVPGH
     KQSIVLFLER VYGIETQELY YRLLEDSFLP DLRAATILDR SDGSESDMAL SMNRYIGNSI
     LPLLIKHSKF YNEAENYASL LDATLHTVYR MSKNRMLTKG QREAVSDFLV ALTSAMHPAM
     LLKLLRKLTV DVSKLSEYTT VALRLLTLHY DRCAKYYGTT GSGQASQFGA SSDEEKRLTM
     LLFSNIFDSL SNMDYDPELF GKALPCLIAI GCALPPDYSL SKNSDDDLYG KPTTSPDQPH
     YNPQPIDTTI VQLTNDLNQI IQKFSEHYHD AWASKKFENG WSYGDQWSDS NKTHPRLKPY
     TMLSEYEKER YREPVRESLK ALLALNWRVD HSEVDVPHSN RGSMRRQSKP NLELQGDTGS
     PFNYNPHPVD MTNLTLSREM QNMAERLAEN SHDIWAKKKF EELHQCGGAV HAQLVPYDLL
     TDKEKRKDRE RSQEFLKYLQ YQGLKLHKPS RGMTEEPGVT AAAIEARFAY SLLEKLISYI
     DRATINMKLL KPSTTFSRRS SFKTCSRDIK FFSKVVLPLI EKYFSTNRNY FIAIATATNN
     VGAASLKEKE MVASLFTKLA SLLRYRMAAF GADVRITVRC LQVLVKSIDA KSLTKACPEF
     IRTSMLTFFN NTADDLGQTI FNLQEGKYDR LRGTHLKTST SLAYVNQVIL PVLTALFDHL
     AACDYGSDLL LDEIQVASYK ILSSLYTLGT DTTLTRDRKY LKTEIERHKP ALGSCLGAFS
     SCFPVAFLEP HANKHNPFSL LNRIADTSLE AQDIMTKMES SMPTLETILS EVDHFVESEK
     TYQDAQHIID VILPLLCSYL PFWWNQGPDN VSPQSGNHVT MVTADHMNLL LKNVLKMIKK
     NIANENAPWM TRIASFTQQI IINSSEELLK DVFLPLAERV KKRVDSMFHK EESLRGFLKS
     STDDTSQIEA QIQEDWQLLV RDIYSFYPLL IKYVDLQRNH WLKDNIAEAE ELYNYVAEIF
     NVWSKSQYFL KEEQNFISAN EIDNMALIMP TATRRTAAVS GDMPAAGGKV KKKKRARDKK
     RDKDKEIQSS LMVACLKRLL PVGLNLFAGK EQELVQHCKD RYLKKMPEYE VIEFAHTQLT
     LPDKLDPADE MSWQHYLYSK LGKKEDAIVQ ESVEKADKKQ GNKIEETVER IVAMAKVLYG
     LHMIDHPQQQ SKNVYRSCVS IQRKRAVIAC FRHVSLHSLP RHRACNIFAR TYYELWLEDE
     NVGQEVMIED LTQTFEDAEK KKKEEEEEEG KPDPLTQLVT TFCRGAMTER SGALQEDALY
     MSYASIVARS CGEEEEEGGD EEEGGGGGED EGGASIHEQE MEKQKLLFHQ ARLANRGVAE
     MVLLHISASK GIPSDMVMRT LQLGIAILRG GNIDIQMGML NHLKEKKDVG FFTSIAGLMN
     SCSVLDLDAF ERNTKAEGLG VGAEGAAGEK NMHDAEFTCA LFRFIQLTCE GHNLDWQNYL
     RTQAGNTTTV NVVICTVDYL LRLQESIMDF YWHYSSKELI DSAGKANFFK AIGVASQVFN
     TLTEVIQGPC TQNQQALAHS RLWDAVGGFL FLFSHMQDKL SKHSSQVDLL KELLNLQKDM
     ITMMLSMLEG NVVNGTIGKQ MVDTLVESAS NVELILKYFD MFLKLKDLTS TPSFMEIDPN
     GDGWILPKDF REKMEQQKSY TPEEIDFLLA CCETNHDGKI DYIGFVDRFH EPAKEIGFNL
     AVLLTNLSEH MPNEPRLARF LETAGSVLNY FESFLGRIEI MGSSKRIERV YFEIKEANIE
     QWEKPQIKES KRAFFYSIVT EGGDKEKLEA FVNFCEDAIF EMTHASGLMA SDEDGGNVRR
     EAAFTYISEE EEERAARDPI KRTIQAIKDG LSYSVYMISP SNIKHQIAVL QSKSFPEIIV
     GFFKMIFYAF YYSGFGVSII IKYLVNILMS LMRGSTQEEE EVIVEVEPSL RALPPLPTEE
     PPSTVQAFGL DISKEENGQY RVQPHESPAL SPSSSVEETG ESSPEDGAGE LSAEAASTEP
     PMTLVDLLGG EAAKRAAQER SEAQKAQEAT LANIEAEQKK ASAETKEPAA VTQIDFSKYT
     KKAVSFLARN FYNLKYVALV LAFGINFMLL FYKVTTLGDD EASEGSGDDM MELASGLGSG
     LAEAVLEGGS GDGGSGDGGD EGDGEDPLEK VEVDEDFFYM EHVMRVAALM HSLVSLCMLI
     AYYHLKVPLA IFKREKEIAR RLEFDGLFIA EQPEDDDIKS HWDKLVISAK TFPVNYWDKF
     VKKKVRQKYS ETYDFDSISN LLGMEKNAFA AQESSEGGGF FHFIANIDWR YQIWKAGVTI
     TDNAFLYSLW YFIFSVMGNF NNFFFAAHLL DVAVGFKTLR TILQSVTHNG KQLVLTVMLL
     TIIVYIYTVI AFNFFRKFYI QEDDDGEEGD RKCHDMGTCF VFHLYKGVRA GGGIGDEIGD
     PDGDEYEVYR ILFDISFFFF VIVILLAIIQ GLIIDAFGEL RDQLESVKED MESNCFICGI
     GKDYFDKVPH GFDTHVAQEH NLANYMFFLM HLINKPDTEY TGQETYVWNM YQQRCWDFFP
     VGDCFRKQYE DELSGGGS
//
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