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Database: UniProt
Entry: Q17M43_AEDAE
LinkDB: Q17M43_AEDAE
Original site: Q17M43_AEDAE 
ID   Q17M43_AEDAE            Unreviewed;       815 AA.
AC   Q17M43;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   25-OCT-2017, entry version 83.
DE   SubName: Full=AAEL001123-PA {ECO:0000313|EMBL:EAT47802.1};
GN   Name=5568592 {ECO:0000313|VectorBase:AAEL001123-PA};
GN   ORFNames=AAEL001123 {ECO:0000313|EMBL:EAT47802.1};
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT47802.1, ECO:0000313|Proteomes:UP000008820};
RN   [1] {ECO:0000313|EMBL:EAT47802.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT47802.1};
RA   Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA   Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA   Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G.,
RA   Utterback T., Rogers Y.-H., Kravitz S., Fraser C.M.;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EAT47802.1, ECO:0000313|Proteomes:UP000008820, ECO:0000313|VectorBase:AAEL001123-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT47802.1}, and Liverpool/LVPib12
RC   {ECO:0000313|Proteomes:UP000008820,
RC   ECO:0000313|VectorBase:AAEL001123-PA};
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M.,
RA   Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J.,
RA   Sinkins S.P., Hogenkamp D.G., Amedeo P., Arensburger P.,
RA   Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V.,
RA   Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B.,
RA   DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M.,
RA   Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H.,
RA   Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S.,
RA   Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D.,
RA   Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A.,
RA   Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D.,
RA   White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A.,
RA   Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J.,
RA   Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B.,
RA   Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
RN   [3] {ECO:0000313|EMBL:EAT47802.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT47802.1};
RG   VectorBase;
RL   Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|VectorBase:AAEL001123-PA}
RP   IDENTIFICATION.
RC   STRAIN=Liverpool/LVPib12 {ECO:0000313|VectorBase:AAEL001123-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
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DR   EMBL; CH477208; EAT47802.1; -; Genomic_DNA.
DR   RefSeq; XP_001652424.1; XM_001652374.1.
DR   ProteinModelPortal; Q17M43; -.
DR   STRING; 7159.AAEL001123-PA; -.
DR   EnsemblMetazoa; AAEL001123-RA; AAEL001123-PA; AAEL001123.
DR   GeneID; 5568592; -.
DR   KEGG; aag:AaeL_AAEL001123; -.
DR   VectorBase; AAEL001123-RA; AAEL001123-PA; AAEL001123.
DR   eggNOG; KOG3676; Eukaryota.
DR   eggNOG; ENOG4110DG4; LUCA.
DR   HOGENOM; HOG000007724; -.
DR   InParanoid; Q17M43; -.
DR   KO; K04974; -.
DR   OMA; NMRGAVG; -.
DR   OrthoDB; EOG091G02JZ; -.
DR   PhylomeDB; Q17M43; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   CDD; cd00204; ANK; 3.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR024862; TRPV.
DR   PANTHER; PTHR10582; PTHR10582; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SMART; SM00248; ANK; 5.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00933366}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008820};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008820};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    511    532       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    553    574       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    580    596       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    617    639       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    659    677       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    689    711       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      179    335       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT      179    211       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      247    279       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   COILED      782    805       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   815 AA;  93479 MW;  B8AFB3FB5091A43A CRC64;
     MGNTESNVTS GVKKQAGVST QALYKFVNLK GGGLLVDMMK RAIQNKQYAE IDHAIKTKVE
     PFLYNKGKGK YIPVAQLVLL RNRERPRSKQ LPEIRALENP EEDFDIDAVC PDVTEGEYQR
     NPSGYREVCW NIKERGAVGE TILHLCLLNA TSLHADLAKR LLRFYPKLIN DIYMCDEYYG
     ESVLHVAIVN EDPAMVKYLL DSGSDVDERC CGTFMCPEDQ KATRYDSIET EIICVLPMTN
     YDGYVYWGEY PLSFAACLGQ EECYRLVLAR GADPDNQDSN GNTVLHMLVI YEKISTFDMA
     YEVGSSLDIR NLQNLTPLTL AAKLGRVEMF FHIMNIEREI YWQLGAITCA AYPLALIDTI
     DIETGNINKD SALNLVVFGD KAEHLDLLEG VLIDLLKTKW NSFVKDKFYR QFFVFFWYFC
     VSLVSFTLRR GPMNLEETAA NRTTTSITLK NLTFSDSTNA TLPTLLAADV NEKIVQFIAN
     ETLFDPAVME ENTFFNSKCA TMAYDTLQDK IRLVSEIIIL IGSFLYLVGA LREFRFLGRK
     MFFENLMISP SRVMFLFSCC IMMIVPFLKV LCLIELEDHV AVTIMLTTAP YFLFFCRGFK
     TVGPFVVMIY RMVMGDLLRF VVIYLVFVMG FSQAYYIVFL SFKGEEEGDE NPMPSPMESI
     VAMFLMSLTN FGDYYGALEK TEHEGCAKVL FVIFMVIVAV LLVNLLIAMM GNTYTMIAET
     KNEWQRQWAR IVLVVERGVP PSERLKNFMS YSQPMSDGRR ALVLRLHMTD EDKEEMKEIL
     EMKRVHERLK KKRQVERELR AEQRRLIMEK YANVP
//
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