ID Q17MW1_AEDAE Unreviewed; 1018 AA.
AC Q17MW1;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE RecName: Full=Peroxisomal ATPase PEX1 {ECO:0000256|ARBA:ARBA00034532};
DE AltName: Full=Peroxin-1 {ECO:0000256|ARBA:ARBA00032509};
GN ORFNames=AAEL000895 {ECO:0000313|EMBL:EAT48041.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT48041.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT48041.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT48041.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT48041.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT48041.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT48041.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT48041.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00034440};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00034440};
CC -!- SIMILARITY: Belongs to the AAA ATPase family.
CC {ECO:0000256|ARBA:ARBA00006914}.
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DR EMBL; CH477203; EAT48041.1; -; Genomic_DNA.
DR RefSeq; XP_001651642.1; XM_001651592.1.
DR AlphaFoldDB; Q17MW1; -.
DR STRING; 7159.Q17MW1; -.
DR PaxDb; 7159-AAEL000895-PA; -.
DR VEuPathDB; VectorBase:AAEL026995; -.
DR eggNOG; KOG0735; Eukaryota.
DR HOGENOM; CLU_000688_1_2_1; -.
DR OMA; YHKTYAR; -.
DR PhylomeDB; Q17MW1; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0007031; P:peroxisome organization; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd19526; RecA-like_PEX1_r2; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.10.330.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR029067; CDC48_domain_2-like_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015342; PEX1-N_C-lobe.
DR PANTHER; PTHR23077; AAA-FAMILY ATPASE; 1.
DR PANTHER; PTHR23077:SF12; PEROXISOME BIOGENESIS FACTOR 1; 1.
DR Pfam; PF00004; AAA; 2.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF09262; PEX-1N; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF54585; Cdc48 domain 2-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00674; AAA; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 764..900
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
SQ SEQUENCE 1018 AA; 114691 MW; 7F7829E0340AC822 CRC64;
MFRRTFTVSY SPFRNNYVTL PDNYHRMLSS YKNGCLSITH GIDSFFMSWS PFGGGGYQDN
RIGINAQVAT AMGLKEGDAV MVAMIIEARS LKTVEVTAAS EKDWDMLQVS SSRIQSILLD
QTRIVTKGQN LIVWVNDSIS IKIKIKFTIP PLPYGRLEND TELVVEPYKK PMLKKDAQTV
PSALTRSNTN LNIAELVRMR NQQRSKPNGI ENGDTLISSV ASAQFKNKSQ YLDDLVATLT
REVPKSYEFR VIRGVWNCRR NNSQICDIYI TKENIPAGMD IHLPFLLSTN DDREYFVNVR
LTSDAERFPS NAYPTVEVND KLMEQLEIHH GEKITLRAKQ NALNIVDMIE LIPATKVASK
IESDIVEKFK EFILFNSKVH PVLLNQGQVF RLPEYYLTVK LQPGNLKYCL VNAVILRQSK
ILCSGEVKNL NGVVPSEEDE KKRCLVVGVE DQKVVKIGKF QKIVDDCVDQ LKLKLCLDER
SAVRKSYNVI VAGSNQSGKR TIVQTVLRRL AEAPYHCFTT TFQCSKHKGR KPDSIQKDLR
HAFYMCMFHS PAVLYLEGLD VLTHNPGDQN TQDAEYHNKV SDVIRKQIEE FTSTNPISVI
ASISSVANLN RRLYSSRGSH LFHDLQKVPN LDKTDREIVI KSLFVNKRCK LEKKINWKKL
ANSTEGYSVG SLVQMVDRAV FYAFKKNSKS PLVTDEMIGS ALDVTNEYCL QGIESHKRSD
EPDDEDDVPG DKVPGLENAI DVFQEVLMWP TKFPKIFECS PLRNQAGILL FGPPGTGKTY
LVSKLAKTWN LRMISVKGPE LLAKYIGQSE ENVRNLFDRA RSAKPCVLFF DEFDSLAPRR
GHDSTGVTDR VVNQLLTELD GVEGLQGVTV IGATSRPELL DPALLRSGRI DRLVECSLPD
EKSRLAIFKN QSSSLDLAAD VQLPQFAKKA NSYTGADIQS ILTTANMLAV QECLTSAEDD
EHVPEKITIN QRHLLEAFAS TRPSLSPQDV QKYKDTYARF TNKEPPSRDF VAKRATLA
//
