ID Q17NP6_AEDAE Unreviewed; 1743 AA.
AC Q17NP6;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 124.
DE SubName: Full=AAEL000597-PA {ECO:0000313|EMBL:EAT48357.1};
GN ORFNames=AAEL000597 {ECO:0000313|EMBL:EAT48357.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT48357.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT48357.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT48357.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT48357.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT48357.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT48357.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT48357.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU003318};
CC Single-pass type I membrane protein {ECO:0000256|RuleBase:RU003318}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; CH477197; EAT48357.1; -; Genomic_DNA.
DR RefSeq; XP_001649196.1; XM_001649146.1.
DR STRING; 7159.Q17NP6; -.
DR PaxDb; 7159-AAEL000597-PA; -.
DR VEuPathDB; VectorBase:AAEL000597; -.
DR eggNOG; KOG3594; Eukaryota.
DR OMA; EPWCAKV; -.
DR PhylomeDB; Q17NP6; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0001736; P:establishment of planar polarity; IEA:UniProt.
DR GO; GO:0007163; P:establishment or maintenance of cell polarity; IEA:UniProt.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00110; LamG; 2.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF422; NEURAL-CADHERIN 2-RELATED; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF02210; Laminin_G_2; 2.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49313; Cadherin-like; 7.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|RuleBase:RU003318};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1564..1587
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..162
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 163..278
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 279..390
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 391..509
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 510..614
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 614..733
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 991..1027
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1028..1234
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1237..1277
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1280..1471
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1514..1552
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 1017..1026
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1267..1276
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1523..1540
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1542..1551
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1743 AA; 197015 MW; E15DF2A10566A5B2 CRC64;
MVSYTGRLQR VDNWICSGND LGLTIIPDWR CQNCYPQVLL KMHITKFIRI GIADKNDNPP
YFDKALYEAE VDENEDIQHT VLTVTAKDHD ESSRIRYEIT SGNIGGAFAV KNMTGAIYVA
GALDYETRKR YELRLAASDN LKENYTTVVI HVKDVNDNPP VFGRPTYQAQ ITEEDDRNLP
KRILQVTATD GDKDRPQNIV YFLTGQGIDP DNPANSKFDI NRTSGDIFVL KPLDRDQPNG
RPQWRFTVFA QDEGGEGLVG YADVQVNLKD INDNAPIFPQ GVYFGNVTEN GTAGMVVMTM
TAVDYDDPNE GTNAKLIYSI EKNVIEEETG SPIFEIEADT GVIKTAVCCL DRERTPDYSI
QVVAMDGGGL KGTGTASIRV KDINDMPPQF TKDEWFTEVD ETDGTNLPEM PILTVTVHDE
DETNKFQYKV IDNSGYGADK FTMVRNNDGT GSLKIVQPLD YEDQLQSNGF RFRIQVNDKG
EDNDNDKYHV AYSWVVVKLR DINDNKPQFE RPNIEVSVYE NADVGKTLET FKATDPDQGG
RSKVSYAIDR SSDRQRQFSI NQEGTVTIQR QLDREVTPRH QVKILAIDDG IPPKTATATL
TVIVQDINDN PPKFLKDYRP VLPEHVPPRK VVEILATDDD DRSKSNGPPF QFRLDPGADD
IIRASFKVEQ DQKGANGDGM AIVSSLRSFD REQQKEYLIP IVIKDHGNPA MTGTSTLTVV
IGDVNDNKMQ PGAKEIFVYN YLGQAPDTQI GRVYVYDLDD WDLPDKKFHW ETNHEHPRFK
LDEDTGMITM RTGTKDGRYN LRFKVYDRKH TQADVPANVT VTVREIPHDA VINSGSIRIA
GITDEDFIRV WNYRTQTVTK SKLDRFKDKL ADLLNTDREN VDVFSVQLRR KHPPLTDVRF
SAHGSPYYKP VRLNGIVLMH REEIEKDVGI NITMVGIDEC LYENQMCEGS CTNTLDISSL
PYMVNANKTS LVGVRVDVLA ECTCGARNFS KAESCRSSPC YNGGRCMETR YGLTCSCPTG
YTGPRCQQTT RSFRGNGWAW YPPLDMCDDS HLSFEFITRK SDGLLLYNGP IVPPERDELL
VSDFISVELE RGYPRLLIDF GSGTLELRVK TKTTLDNGEW HRLDIFWDTE NVRMVVDYCK
SAEVNEMEDG STPEFDDATC QARGTIPPFN EYLNVNAPLQ IGGFYREQFD PTHYRWNYMP
MGKGFDGCIK NLVHNSKLYD LAHPGLSRNS VAGCPQTEEV CSQSEQTSRC WEHGNCVGSF
TEARCQCRPG WTGPACNIPT IPTTFKQQSY VKYALSFEPD RFSTLVQLRF RTREQHGELF
RVSDQHNREY GILEIKDARL RFRYNLNSLR TEERDIWLNA IAVDDGQWHV VRVNRHGSAA
TLELDGGEGR RYNETFTFDG HQWLLVDKQE GVYAGGKAEY TGVRTFEVYA DYQKSCLDDI
RLEGKHLPLP PAMNGTQWGQ ATMARNLERN CPSNKPCANV ICPDPFECVD LWNEYECTCG
EGRVMSPDGK GCMDRNECLD LPCLNGGICV NQEPKLRYRC DCPDGFWGEN CELIQEGQTL
KLSMGALAAI LVCLLIILIL VLVFVVYNRR RESHIKYPGP DDDVRENIIN YDDEGGGEDD
MTAYDITPLQ IPIGPMPELT QCKMPPLMYP VMTMGPGHEP NVGMFIEEHK KRADSDPNAP
PFDDLRNYAY EGGGSTAGSL SSLQSGTDDE VQEFDYLDAW GPRFDKLANM YGDHHPTELD
ELH
//
