ID   Q17ZI3_HELAH            Unreviewed;       332 AA.
AC   Q17ZI3;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   27-MAR-2024, entry version 93.
DE   SubName: Full=Hydrogenase expression/formation protein {ECO:0000313|EMBL:CAJ98943.1};
GN   Name=hypE {ECO:0000313|EMBL:CAJ98943.1};
GN   OrderedLocusNames=Hac_0082 {ECO:0000313|EMBL:CAJ98943.1};
OS   Helicobacter acinonychis (strain Sheeba).
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=382638 {ECO:0000313|EMBL:CAJ98943.1, ECO:0000313|Proteomes:UP000000775};
RN   [1] {ECO:0000313|EMBL:CAJ98943.1, ECO:0000313|Proteomes:UP000000775}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sheeba {ECO:0000313|EMBL:CAJ98943.1,
RC   ECO:0000313|Proteomes:UP000000775};
RX   PubMed=16789826; DOI=10.1371/journal.pgen.0020120;
RA   Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G.,
RA   Gressmann H., Achtman M., Schuster S.C.;
RT   "Who ate whom? Adaptive Helicobacter genomic changes that accompanied a
RT   host jump from early humans to large felines.";
RL   PLoS Genet. 2:1097-1110(2006).
CC   -!- SIMILARITY: Belongs to the HypE family.
CC       {ECO:0000256|ARBA:ARBA00006243}.
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DR   EMBL; AM260522; CAJ98943.1; -; Genomic_DNA.
DR   RefSeq; WP_011577065.1; NC_008229.1.
DR   AlphaFoldDB; Q17ZI3; -.
DR   STRING; 382638.Hac_0082; -.
DR   KEGG; hac:Hac_0082; -.
DR   eggNOG; COG0309; Bacteria.
DR   HOGENOM; CLU_049733_0_0_7; -.
DR   OrthoDB; 9801934at2; -.
DR   BioCyc; HACI382638:HAC_RS00380-MONOMER; -.
DR   Proteomes; UP000000775; Chromosome.
DR   CDD; cd02197; HypE; 1.
DR   Gene3D; 3.90.650.10; PurM-like C-terminal domain; 1.
DR   Gene3D; 3.30.1330.10; PurM-like, N-terminal domain; 1.
DR   InterPro; IPR011854; HypE.
DR   InterPro; IPR010918; PurM-like_C_dom.
DR   InterPro; IPR036676; PurM-like_C_sf.
DR   InterPro; IPR016188; PurM-like_N.
DR   InterPro; IPR036921; PurM-like_N_sf.
DR   NCBIfam; TIGR02124; hypE; 1.
DR   PANTHER; PTHR30303:SF0; CARBAMOYL DEHYDRATASE HYPE; 1.
DR   PANTHER; PTHR30303; HYDROGENASE ISOENZYMES FORMATION PROTEIN HYPE; 1.
DR   Pfam; PF00586; AIRS; 1.
DR   Pfam; PF02769; AIRS_C; 1.
DR   PIRSF; PIRSF005644; Hdrgns_mtr_HypE; 1.
DR   SUPFAM; SSF56042; PurM C-terminal domain-like; 1.
DR   SUPFAM; SSF55326; PurM N-terminal domain-like; 1.
PE   3: Inferred from homology;
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842}.
FT   DOMAIN          41..147
FT                   /note="PurM-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00586"
FT   DOMAIN          158..310
FT                   /note="PurM-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02769"
SQ   SEQUENCE   332 AA;  36306 MW;  97FCA73F6B0AAFDB CRC64;
     MESVTLACGN GGKETNALIE RVFMPYLKEL ISAFGEDAPK FEANGEYCVS TDSFVITPLT
     FNGGDIGKLC VCGSANDVSM QGGKPLYLNI GFILEEGLEI ALLKQILQSM QKELFKANLK
     LLSLDTKVVP KGSVDKLFIN TTCIGKIIKT GISSHHLKQG QAIIVSDTIA NHGASLFAMR
     NEIKLKTNLK SDCQLLYPLV RPLFLSNLKI HALRDATRGG LASVLNEWAN SSKVKIVIEE
     EKIPLKEETK GICEILGLEP YALANEGVFV LALNQKDAPK ALEILKSNEQ AKNACMIGEV
     LESPYPIVVL KNAWGFERIL EMPEGELLPR IC
//