ID Q180F8_CLOD6 Unreviewed; 461 AA.
AC Q180F8;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=Iron hydrogenase {ECO:0000313|EMBL:CAJ70211.1};
DE EC=1.12.7.2 {ECO:0000313|EMBL:CAJ70211.1};
GN Name=hydA {ECO:0000313|EMBL:CAJ70211.1};
GN OrderedLocusNames=CD630_33140 {ECO:0000313|EMBL:CAJ70211.1};
OS Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC Clostridioides.
OX NCBI_TaxID=272563 {ECO:0000313|EMBL:CAJ70211.1, ECO:0000313|Proteomes:UP000001978};
RN [1] {ECO:0000313|EMBL:CAJ70211.1, ECO:0000313|Proteomes:UP000001978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=630 {ECO:0000313|EMBL:CAJ70211.1,
RC ECO:0000313|Proteomes:UP000001978};
RX PubMed=16804543; DOI=10.1038/ng1830;
RA Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA Price C., Rabbinowitsch R., Sharp S., Simmonds M., Steven K., Unwin L.,
RA Whithead S., Dupuy B., Dougan G., Barrell B.and.Parkhill.J.;
RT "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT mobile, mosaic genome.";
RL Nat. Genet. 38:779-786(2006).
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DR EMBL; AM180355; CAJ70211.1; -; Genomic_DNA.
DR RefSeq; YP_001089830.1; NC_009089.1.
DR AlphaFoldDB; Q180F8; -.
DR STRING; 272563.CD630_33140; -.
DR EnsemblBacteria; CAJ70211; CAJ70211; CD630_33140.
DR KEGG; cdf:CD630_33140; -.
DR PATRIC; fig|272563.8.peg.3468; -.
DR eggNOG; COG1143; Bacteria.
DR eggNOG; COG4624; Bacteria.
DR OrthoDB; 9805142at2; -.
DR PhylomeDB; Q180F8; -.
DR BioCyc; PDIF272563:G12WB-3481-MONOMER; -.
DR Proteomes; UP000001978; Chromosome.
DR GO; GO:0008901; F:ferredoxin hydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.20; -; 1.
DR Gene3D; 3.40.50.1780; -; 1.
DR Gene3D; 4.10.260.20; Iron hydrogenase, small subunit; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR009016; Fe_hydrogenase.
DR InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR InterPro; IPR003149; Fe_hydrogenase_ssu.
DR InterPro; IPR036991; Fe_hydrogenase_ssu_sf.
DR InterPro; IPR013352; Fe_hydrogenase_subset.
DR NCBIfam; TIGR02512; FeFe_hydrog_A; 1.
DR PANTHER; PTHR11615:SF6; NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11615; NITRATE, FORMATE, IRON DEHYDROGENASE; 1.
DR Pfam; PF02906; Fe_hyd_lg_C; 1.
DR Pfam; PF02256; Fe_hyd_SSU; 1.
DR Pfam; PF13237; Fer4_10; 1.
DR SMART; SM00902; Fe_hyd_SSU; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF53920; Fe-only hydrogenase; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000313|EMBL:CAJ70211.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001978}.
FT DOMAIN 4..33
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 34..63
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
SQ SEQUENCE 461 AA; 51232 MW; 1CEAD3CC0A2C63BB CRC64;
MTFMIINIDK DLCTGCRECS KVCPVNAIEG EEGKPQEINL DRCVMCGQCV QTCKSYASVI
DEGFEFLQEK KQEREIPESI NEPIFAAYNV CDIDKVKKAL SDPNVFTMVQ CAPAVRVALG
EDFGYYLGYL GAGKMAAALR ALNFDRVYDT NFAADLTIME EGSELIKRVT EGGTLPMFTS
CCPAWVKFME KNYPKLTNHL SSCKSPQQMG GAIFKTYGAE INNVDASKIF SVSIMPCTCK
KYECDREEMD SSGYRDVDVV LTTRELAYLI KDMGIDFKNL REEKFDSPLG SYSGAGTIFG
VTGGVMEAAI RTGYELITGE SIPDVEVKQV RGENGFRKST IKIGDLDLRV GVVSGLKNVI
PVLEDLEKGK LDVDFIEVMT CPVGCVSGGG QPKILLEEYK ELAYENRTKA TYVHDEHLAI
RKSHENPDIK KLYDEYLVEP LGEKSHHLLH TTYCIGKEVA K
//
