ID Q184J7_CLOD6 Unreviewed; 381 AA.
AC Q184J7;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Alcohol dehydrogenase {ECO:0000313|EMBL:CAJ69900.1};
DE EC=1.1.1.1 {ECO:0000313|EMBL:CAJ69900.1};
GN OrderedLocusNames=CD630_30060 {ECO:0000313|EMBL:CAJ69900.1};
OS Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC Clostridioides.
OX NCBI_TaxID=272563 {ECO:0000313|EMBL:CAJ69900.1, ECO:0000313|Proteomes:UP000001978};
RN [1] {ECO:0000313|EMBL:CAJ69900.1, ECO:0000313|Proteomes:UP000001978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=630 {ECO:0000313|EMBL:CAJ69900.1,
RC ECO:0000313|Proteomes:UP000001978};
RX PubMed=16804543; DOI=10.1038/ng1830;
RA Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA Price C., Rabbinowitsch R., Sharp S., Simmonds M., Steven K., Unwin L.,
RA Whithead S., Dupuy B., Dougan G., Barrell B.and.Parkhill.J.;
RT "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT mobile, mosaic genome.";
RL Nat. Genet. 38:779-786(2006).
CC -!- SIMILARITY: Belongs to the iron-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00007358}.
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DR EMBL; AM180355; CAJ69900.1; -; Genomic_DNA.
DR RefSeq; WP_003439845.1; NZ_JAUPES010000017.1.
DR RefSeq; YP_001089524.1; NC_009089.1.
DR AlphaFoldDB; Q184J7; -.
DR STRING; 272563.CD630_30060; -.
DR EnsemblBacteria; CAJ69900; CAJ69900; CD630_30060.
DR KEGG; cdf:CD630_30060; -.
DR KEGG; pdc:CDIF630_03291; -.
DR PATRIC; fig|272563.120.peg.3173; -.
DR eggNOG; COG1454; Bacteria.
DR OrthoDB; 9804734at2; -.
DR PhylomeDB; Q184J7; -.
DR BioCyc; PDIF272563:G12WB-3171-MONOMER; -.
DR Proteomes; UP000001978; Chromosome.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd08188; PDDH; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR001670; ADH_Fe/GldA.
DR InterPro; IPR018211; ADH_Fe_CS.
DR InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR PANTHER; PTHR11496; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR11496:SF102; ALCOHOL DEHYDROGENASE 4; 1.
DR Pfam; PF00465; Fe-ADH; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
DR PROSITE; PS00913; ADH_IRON_1; 1.
DR PROSITE; PS00060; ADH_IRON_2; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:CAJ69900.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001978}.
FT DOMAIN 10..373
FT /note="Alcohol dehydrogenase iron-type/glycerol
FT dehydrogenase GldA"
FT /evidence="ECO:0000259|Pfam:PF00465"
SQ SEQUENCE 381 AA; 41115 MW; CC6ACEB7D6C00B61 CRC64;
MSIYYVPPIN LLGKGCLNEA KDSIKSLGTK KAFIVSDKFL VSNGTVKKVT DILSQIDIDF
VVYDEVKQNP TVTNVNKGLK ILKSENCDFV ITIGGGSPQD CGKAISILAT NGGDIRDYEG
INKTSKKCLP IIAITTTAGT SAEVTINYVI TDEDRHVKMI MVDTNSLATM TVNDPELMIS
KPSNLTAATG MDALTHAIEA VVANGAYDVT DSTALYAIKQ IFKYLPRAVK NGNDIEAREQ
MCYACFLNGI AFSNAGLGNV HAMAHQLGGL YDLPHGVCNA MLLPIVEEEN AKSAPAKFRP
IAEVIGMDVN NKSDKECVDF VIDKIKALSE EVGIPKSLKD VGVDNPNFEL LAENSMKDAC
AGANPVFFDK DKIIELFMKI S
//
