ID Q18BS5_CLOD6 Unreviewed; 482 AA.
AC Q18BS5;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 116.
DE SubName: Full=Transcriptional regulator, GntR family {ECO:0000313|EMBL:CAJ68270.1};
GN OrderedLocusNames=CD630_14070 {ECO:0000313|EMBL:CAJ68270.1};
OS Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC Clostridioides.
OX NCBI_TaxID=272563 {ECO:0000313|EMBL:CAJ68270.1, ECO:0000313|Proteomes:UP000001978};
RN [1] {ECO:0000313|EMBL:CAJ68270.1, ECO:0000313|Proteomes:UP000001978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=630 {ECO:0000313|EMBL:CAJ68270.1,
RC ECO:0000313|Proteomes:UP000001978};
RX PubMed=16804543; DOI=10.1038/ng1830;
RA Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA Price C., Rabbinowitsch R., Sharp S., Simmonds M., Steven K., Unwin L.,
RA Whithead S., Dupuy B., Dougan G., Barrell B.and.Parkhill.J.;
RT "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT mobile, mosaic genome.";
RL Nat. Genet. 38:779-786(2006).
CC -!- SIMILARITY: In the C-terminal section; belongs to the class-I
CC pyridoxal-phosphate-dependent aminotransferase family.
CC {ECO:0000256|ARBA:ARBA00005384}.
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DR EMBL; AM180355; CAJ68270.1; -; Genomic_DNA.
DR RefSeq; WP_009902483.1; NZ_JAUPES010000036.1.
DR RefSeq; YP_001087907.1; NC_009089.1.
DR AlphaFoldDB; Q18BS5; -.
DR STRING; 272563.CD630_14070; -.
DR DNASU; 4914968; -.
DR EnsemblBacteria; CAJ68270; CAJ68270; CD630_14070.
DR KEGG; cdf:CD630_14070; -.
DR KEGG; pdc:CDIF630_01568; -.
DR PATRIC; fig|272563.120.peg.1474; -.
DR eggNOG; COG1167; Bacteria.
DR OrthoDB; 9802328at2; -.
DR PhylomeDB; Q18BS5; -.
DR BioCyc; PDIF272563:G12WB-1545-MONOMER; -.
DR Proteomes; UP000001978; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0008483; F:transaminase activity; IEA:UniProt.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00609; AAT_like; 1.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR42790; AMINOTRANSFERASE; 1.
DR PANTHER; PTHR42790:SF8; GNTR-FAMILY TRANSCRIPTIONAL REGULATOR; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR Pfam; PF00392; GntR; 1.
DR PRINTS; PR00035; HTHGNTR.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001978};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 12..80
FT /note="HTH gntR-type"
FT /evidence="ECO:0000259|PROSITE:PS50949"
SQ SEQUENCE 482 AA; 55624 MW; 8E9C8CCCC9AD6BCE CRC64;
MIFSNLKLND NEPIYIQLKN YISDMISKGL IPDNSKLPST RELSQLLQVS RNSVVLTYEE
LKSEGLIYSI SGKGTFVKSK NKSSNTTWSL NWDCLENTYS KKANELDIIK SEIPWSSDLI
SFKSISPDGD LFDMEELKKS FLNRISLEGH KLLNYGYAQG YKPLIDYLLE YMTNKGADIS
NKDILITNGF TEGFDIIMSS FTQEKDYIIC ENPTHNTAIK IMKSHNLNIL GVDINEDGLD
FNMLEDNLIK YKNKIKFAYI TPSYHNPTGI VMTPENRYKF YNLMKKYNIA IIEDGFNEEL
LYNSSHIFPI CSLDNMNNGV VYIGSFSKIL FPGMRIGWIF ADKKVINKLE SVKRCRNIHV
SFLDQGILFD YLSNGGFEKY IKKIRKFYGD KFNFAYKCIK KYIKTEYILG DGGLHIFIKL
KNIDTRVLLE KCYEKNVIFM PGDLFFTDNS GFDTLRLGFS RLSFEDIEIG IKIIGETINE
MF
//
