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Database: UniProt
Entry: Q18EW2_HALWD
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Original site: Q18EW2_HALWD 
ID   Q18EW2_HALWD            Unreviewed;       375 AA.
AC   Q18EW2;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   25-OCT-2017, entry version 84.
DE   RecName: Full=Transcription initiation factor IIB {ECO:0000256|HAMAP-Rule:MF_00383};
DE            Short=TFIIB {ECO:0000256|HAMAP-Rule:MF_00383};
GN   Name=tfbA7 {ECO:0000313|EMBL:CAJ53505.1};
GN   Synonyms=tfb {ECO:0000256|HAMAP-Rule:MF_00383};
GN   OrderedLocusNames=HQ_3408A {ECO:0000313|EMBL:CAJ53505.1};
OS   Haloquadratum walsbyi (strain DSM 16790 / HBSQ001).
OC   Archaea; Euryarchaeota; Halobacteria; Haloferacales; Haloferacaceae;
OC   Haloquadratum.
OX   NCBI_TaxID=362976 {ECO:0000313|EMBL:CAJ53505.1, ECO:0000313|Proteomes:UP000001975};
RN   [1] {ECO:0000313|EMBL:CAJ53505.1, ECO:0000313|Proteomes:UP000001975}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16790 / HBSQ001 {ECO:0000313|Proteomes:UP000001975};
RX   PubMed=16820047; DOI=10.1186/1471-2164-7-169;
RA   Bolhuis H.H., Palm P.P., Wende A.W., Falb M.M., Rampp M.M.,
RA   Rodriguez-Valera F.F., Pfeiffer F.F., Oesterhelt D.D.;
RT   "The genome of the square archaeon Haloquadratum walsbyi: life at the
RT   limits of water activity.";
RL   BMC Genomics 7:169-169(2006).
CC   -!- FUNCTION: Stabilizes TBP binding to an archaeal box-A promoter.
CC       Also responsible for recruiting RNA polymerase II to the pre-
CC       initiation complex (DNA-TBP-TFIIB). {ECO:0000256|HAMAP-
CC       Rule:MF_00383}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00383};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|HAMAP-
CC       Rule:MF_00383};
CC   -!- SIMILARITY: Belongs to the TFIIB family. {ECO:0000256|HAMAP-
CC       Rule:MF_00383}.
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DR   EMBL; AM180088; CAJ53505.1; -; Genomic_DNA.
DR   RefSeq; WP_011572602.1; NC_008212.1.
DR   ProteinModelPortal; Q18EW2; -.
DR   STRING; 362976.HQ3408A; -.
DR   EnsemblBacteria; CAJ53505; CAJ53505; HQ_3408A.
DR   GeneID; 4194758; -.
DR   KEGG; hwa:HQ_3408A; -.
DR   eggNOG; arCOG01981; Archaea.
DR   eggNOG; COG1405; LUCA.
DR   HOGENOM; HOG000108633; -.
DR   KO; K03124; -.
DR   OMA; REVACVI; -.
DR   OrthoDB; POG093Z07LX; -.
DR   Proteomes; UP000001975; Chromosome.
DR   GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR   GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0070897; P:DNA-templated transcriptional preinitiation complex assembly; IEA:InterPro.
DR   CDD; cd00043; CYCLIN; 2.
DR   Gene3D; 1.10.472.10; -; 2.
DR   HAMAP; MF_00383; TF2B_arch; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR000812; TFIIB.
DR   InterPro; IPR023484; TFIIB_arc.
DR   InterPro; IPR023486; TFIIB_CS.
DR   InterPro; IPR013150; TFIIB_cyclin.
DR   InterPro; IPR013137; Znf_TFIIB.
DR   PANTHER; PTHR11618; PTHR11618; 1.
DR   Pfam; PF08271; TF_Zn_Ribbon; 1.
DR   Pfam; PF00382; TFIIB; 2.
DR   PRINTS; PR00685; TIFACTORIIB.
DR   SMART; SM00385; CYCLIN; 2.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00782; TFIIB; 1.
DR   PROSITE; PS51134; ZF_TFIIB; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001975};
KW   Initiation factor {ECO:0000313|EMBL:CAJ53505.1};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00383, ECO:0000256|PROSITE-
KW   ProRule:PRU00469};
KW   Protein biosynthesis {ECO:0000313|EMBL:CAJ53505.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001975};
KW   Repeat {ECO:0000256|HAMAP-Rule:MF_00383};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_00383};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00383};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00383, ECO:0000256|PROSITE-
KW   ProRule:PRU00469};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00469}.
FT   DOMAIN       76    106       TFIIB-type. {ECO:0000259|PROSITE:
FT                                PS51134}.
FT   REPEAT      192    275       1. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   REPEAT      286    367       2. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   ZN_FING      76    106       TFIIB-type. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00469}.
FT   METAL        80     80       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   METAL        83     83       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   METAL        98     98       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   METAL       101    101       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
SQ   SEQUENCE   375 AA;  41373 MW;  7A04DC90F1C7F64F CRC64;
     MYTNNAPVTN QTETGTSSDT EEEETADTEE DNNDERSNEG DVSTKPTMTR RTGDTEVAIT
     QVEDEFNSTS AKVVDEQIGC PECGGDTVAS ADSPETICSA CGLVITEDEI DRGPEWRGFN
     AKERNQKSRV GAPTTALMHD KGLSTNIGWQ NKDAYGQSVS AEKRRKLKRL RTWNERIRTQ
     DSKDRNLKHA LGEIDRMSSA LDIHETTRET ASMIYRRALD ADLLPGRSIE GVATAVLYAA
     SRIDGVARSI DELASVSRVP ALEIKRTYRY IIRELDLQIP PTNPIEYIGR FASAIECNDE
     TERRARALTQ QATEKGVHSG KHPVGIAASA LYAAGQLCND RLTQSEISNA ADVSEVTIRN
     RYREILEAAE EVTSP
//
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