ID   Q18NV0_9CREN            Unreviewed;       228 AA.
AC   Q18NV0;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2009, sequence version 2.
DT   27-MAR-2024, entry version 49.
DE   SubName: Full=Cbf5 {ECO:0000313|EMBL:BAE96934.2};
DE   Flags: Fragment;
OS   Thermosphaera aggregans.
OC   Archaea; Thermoproteota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Thermosphaera.
OX   NCBI_TaxID=54254 {ECO:0000313|EMBL:BAE96934.2};
RN   [1] {ECO:0000313|EMBL:BAE96934.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DSM 11486 {ECO:0000313|EMBL:BAE96934.2};
RX   PubMed=16781672; DOI=10.1016/j.bbrc.2006.06.011;
RA   Yoshinari S., Itoh T., Hallam S.J., Delong E.F., Yokobori S., Yamagishi A.,
RA   Oshima T., Kita K., Watanabe Y.;
RT   "Archaeal pre-mRNA splicing: a connection to hetero-oligomeric splicing
RT   endonuclease.";
RL   Biochem. Biophys. Res. Commun. 346:1024-1032(2006).
RN   [2] {ECO:0000313|EMBL:BAE96934.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DSM 11486 {ECO:0000313|EMBL:BAE96934.2};
RX   PubMed=19671140; DOI=10.1186/1471-2148-9-198;
RA   Yokobori S., Itoh T., Yoshinari S., Nomura N., Sako Y., Yamagishi A.,
RA   Oshima T., Kita K., Watanabe Y.;
RT   "Gain and loss of an intron in a protein-coding gene in Archaea: the case
RT   of an archaeal RNA pseudouridine synthase gene.";
RL   BMC Evol. Biol. 9:198-198(2009).
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DR   EMBL; AB245537; BAE96934.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q18NV0; -.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR   Gene3D; 2.30.130.10; PUA domain; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR002501; PsdUridine_synth_N.
DR   InterPro; IPR002478; PUA.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR036974; PUA_sf.
DR   InterPro; IPR004802; tRNA_PsdUridine_synth_B_fam.
DR   InterPro; IPR032819; TruB_C.
DR   NCBIfam; TIGR00425; CBF5; 1.
DR   PANTHER; PTHR23127; CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5; 1.
DR   PANTHER; PTHR23127:SF0; H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1; 1.
DR   Pfam; PF01472; PUA; 1.
DR   Pfam; PF16198; TruB_C_2; 1.
DR   Pfam; PF01509; TruB_N; 1.
DR   SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR   SUPFAM; SSF88697; PUA domain-like; 1.
DR   PROSITE; PS50890; PUA; 1.
PE   4: Predicted;
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235}.
FT   DOMAIN          5..118
FT                   /note="Pseudouridine synthase II N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01509"
FT   DOMAIN          119..185
FT                   /note="tRNA pseudouridylate synthase B C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16198"
FT   DOMAIN          189..227
FT                   /note="PUA"
FT                   /evidence="ECO:0000259|Pfam:PF01472"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAE96934.2"
FT   NON_TER         228
FT                   /evidence="ECO:0000313|EMBL:BAE96934.2"
SQ   SEQUENCE   228 AA;  25431 MW;  CDF9C58FCB48D456 CRC64;
     VAWVKKLFNI DKAGHGGTLD PKVTGVLPVG LDNSTKVIGN VVHSVKEYVM VIQFHGDVEI
     GKLVEALKYF TGEIYQRPPL RSSVKRVLRT RRIHEIELLD FKDRFALVRA SCDPGTYMRK
     LAHDIGLYTG VGAHMRELRR TRTGPYREDE TLVKLQDVSE ALYLWRVEKD ERMLRRVILP
     VETAVTHLPK IVINDLAVDA IAHGASLAAP GVVRLTDNVS AGATVAVF
//