ID Q19088_CAEEL Unreviewed; 414 AA.
AC Q19088;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 163.
DE SubName: Full=FYVE-type domain-containing protein {ECO:0000313|EMBL:CCD65986.1};
GN Name=rabn-5 {ECO:0000313|EMBL:CCD65986.1,
GN ECO:0000313|WormBase:F01F1.4};
GN ORFNames=CELE_F01F1.4 {ECO:0000313|EMBL:CCD65986.1}, F01F1.4
GN {ECO:0000313|WormBase:F01F1.4};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD65986.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD65986.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD65986.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284603; CCD65986.1; -; Genomic_DNA.
DR PIR; T15947; T15947.
DR RefSeq; NP_498266.1; NM_065865.4.
DR AlphaFoldDB; Q19088; -.
DR SMR; Q19088; -.
DR DIP; DIP-26972N; -.
DR IntAct; Q19088; 4.
DR STRING; 6239.F01F1.4.2; -.
DR EPD; Q19088; -.
DR PaxDb; 6239-F01F1-4; -.
DR PeptideAtlas; Q19088; -.
DR EnsemblMetazoa; F01F1.4.1; F01F1.4.1; WBGene00017161.
DR GeneID; 175823; -.
DR KEGG; cel:CELE_F01F1.4; -.
DR UCSC; F01F1.4; c. elegans.
DR AGR; WB:WBGene00017161; -.
DR WormBase; F01F1.4; CE01230; WBGene00017161; rabn-5.
DR eggNOG; KOG0993; Eukaryota.
DR GeneTree; ENSGT00530000063743; -.
DR HOGENOM; CLU_044129_0_0_1; -.
DR InParanoid; Q19088; -.
DR OMA; TLCADNE; -.
DR OrthoDB; 2904642at2759; -.
DR PhylomeDB; Q19088; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00017161; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR GO; GO:0032794; F:GTPase activating protein binding; IPI:WormBase.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR GO; GO:0018996; P:molting cycle, collagen and cuticulin-based cuticle; IGI:WormBase.
DR CDD; cd15739; FYVE_RABE_unchar; 1.
DR Gene3D; 1.20.5.730; Single helix bin; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR003914; Rabaptin.
DR InterPro; IPR015390; Rabaptin_Rab5-bd_dom.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR31179:SF7; FYVE-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR31179; RAB GTPASE-BINDING EFFECTOR PROTEIN; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF09311; Rab5-bind; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|EPD:Q19088,
KW ECO:0007829|PeptideAtlas:Q19088};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 344..402
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 40..145
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 266..314
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 414 AA; 47599 MW; 6F4D5F5BBB46F316 CRC64;
MTEPSASEEV SAGVNAEEPP IPSKKISQVS PNPTLQCEMC QNYEVNLTAL QENERKLKEE
VKAAMELNER YQLDLSNERD YRKELEKKMN ELSTNCLNQV NEAAKANAKS EQRLDELSAK
HDKSIEVFTD QLNLARDKLQ QADDDFVTLG KKYKKLLGST RKSAQELRSE KIDMPADLDQ
LQFICLKNRE ELIETRAAKE HTEQQLQDEI TVLRAQILEE RAHREDQEVT FTAEISRLQS
ELGKINTRMV VASETIADQD SNIRQIRDLQ TTVGELETQV QQVQNERAAV EQTAQNYKQR
CTSLQQELDT SEVVQRDFVK LSQSLQIQLE KIRQSEQEVR WQWDDDVDQC SNCDTSFARV
KVKPHCLHCG RIFCMNCLKD TVPSGPNHRP ANVCKVCHTL LNRDTKPFFA TQDK
//
