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Database: UniProt
Entry: Q199A7_MOUSE
LinkDB: Q199A7_MOUSE
Original site: Q199A7_MOUSE 
ID   Q199A7_MOUSE            Unreviewed;       305 AA.
AC   Q199A7;
DT   11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2006, sequence version 1.
DT   24-JAN-2024, entry version 111.
DE   SubName: Full=Truncated Wilms' tumor protein {ECO:0000313|EMBL:ABF93406.1};
GN   Name=Wt1 {ECO:0000313|MGI:MGI:98968};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:ABF93406.1};
RN   [1] {ECO:0000313|EMBL:ABF93406.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL {ECO:0000313|EMBL:ABF93406.1};
RX   PubMed=16698800; DOI=10.1074/jbc.M512391200;
RA   Hossain A., Nixon M., Kuo M.T., Saunders G.F.;
RT   "N-terminally truncated WT1 protein with oncogenic properties overexpressed
RT   in leukemia.";
RL   J. Biol. Chem. 281:28122-28130(2006).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC   -!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein family.
CC       {ECO:0000256|ARBA:ARBA00005682}.
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DR   EMBL; DQ537939; ABF93406.1; -; mRNA.
DR   RefSeq; NP_659032.3; NM_144783.2.
DR   AlphaFoldDB; Q199A7; -.
DR   DNASU; 22431; -.
DR   GeneID; 22431; -.
DR   KEGG; mmu:22431; -.
DR   AGR; MGI:98968; -.
DR   CTD; 7490; -.
DR   MGI; MGI:98968; Wt1.
DR   OrthoDB; 2898220at2759; -.
DR   BioGRID-ORCS; 22431; 2 hits in 83 CRISPR screens.
DR   Genevisible; Q199A7; MM.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 4.
DR   InterPro; IPR000976; Wilms_tumour_N.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR23235:SF120; KRUEPPEL-LIKE FACTOR 17; 1.
DR   PANTHER; PTHR23235; KRUEPPEL-LIKE TRANSCRIPTION FACTOR; 1.
DR   Pfam; PF02165; WT1; 2.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 4.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   2: Evidence at transcript level;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT   DOMAIN          179..208
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          209..238
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          239..266
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          270..299
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   REGION          16..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   305 AA;  34756 MW;  3EE51D0C7ED621A5 CRC64;
     MEKGYSTVTF DGAPSYGHTP SHHAAQFPNH SFKHEDPMGQ QGSLGEQQYS VPPPVYGCHT
     PTDSCTGSQA LLLRTPYSSD NLYQMTSQLE CMTWNQMNLG ATLKGMAAGS SSSVKWTEGQ
     SNHGIGYESE NHTAPILCGA QYRIHTHGVF RGIQDVRRVS GVAPTLVRSA SETSEKRPFM
     CAYPGCNKRY FKLSHLQMHS RKHTGEKPYQ CDFKDCERRF SRSDQLKRHQ RRHTGVKPFQ
     CKTCQRKFSR SDHLKTHTRT HTGKTSEKPF SCRWHSCQKK FARSDELVRH HNMHQRNMTK
     LHVAL
//
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