ID Q199A7_MOUSE Unreviewed; 305 AA.
AC Q199A7;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 24-JAN-2024, entry version 111.
DE SubName: Full=Truncated Wilms' tumor protein {ECO:0000313|EMBL:ABF93406.1};
GN Name=Wt1 {ECO:0000313|MGI:MGI:98968};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:ABF93406.1};
RN [1] {ECO:0000313|EMBL:ABF93406.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL {ECO:0000313|EMBL:ABF93406.1};
RX PubMed=16698800; DOI=10.1074/jbc.M512391200;
RA Hossain A., Nixon M., Kuo M.T., Saunders G.F.;
RT "N-terminally truncated WT1 protein with oncogenic properties overexpressed
RT in leukemia.";
RL J. Biol. Chem. 281:28122-28130(2006).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC -!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein family.
CC {ECO:0000256|ARBA:ARBA00005682}.
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DR EMBL; DQ537939; ABF93406.1; -; mRNA.
DR RefSeq; NP_659032.3; NM_144783.2.
DR AlphaFoldDB; Q199A7; -.
DR DNASU; 22431; -.
DR GeneID; 22431; -.
DR KEGG; mmu:22431; -.
DR AGR; MGI:98968; -.
DR CTD; 7490; -.
DR MGI; MGI:98968; Wt1.
DR OrthoDB; 2898220at2759; -.
DR BioGRID-ORCS; 22431; 2 hits in 83 CRISPR screens.
DR Genevisible; Q199A7; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 4.
DR InterPro; IPR000976; Wilms_tumour_N.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23235:SF120; KRUEPPEL-LIKE FACTOR 17; 1.
DR PANTHER; PTHR23235; KRUEPPEL-LIKE TRANSCRIPTION FACTOR; 1.
DR Pfam; PF02165; WT1; 2.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 179..208
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 209..238
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 239..266
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 270..299
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 16..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 305 AA; 34756 MW; 3EE51D0C7ED621A5 CRC64;
MEKGYSTVTF DGAPSYGHTP SHHAAQFPNH SFKHEDPMGQ QGSLGEQQYS VPPPVYGCHT
PTDSCTGSQA LLLRTPYSSD NLYQMTSQLE CMTWNQMNLG ATLKGMAAGS SSSVKWTEGQ
SNHGIGYESE NHTAPILCGA QYRIHTHGVF RGIQDVRRVS GVAPTLVRSA SETSEKRPFM
CAYPGCNKRY FKLSHLQMHS RKHTGEKPYQ CDFKDCERRF SRSDQLKRHQ RRHTGVKPFQ
CKTCQRKFSR SDHLKTHTRT HTGKTSEKPF SCRWHSCQKK FARSDELVRH HNMHQRNMTK
LHVAL
//