ID Q1AII9_9HIV1 Unreviewed; 326 AA.
AC Q1AII9;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AAZ84373.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AAZ84373.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAZ84373.1}
RP NUCLEOTIDE SEQUENCE.
RA Loutfy M.R., Walmsley S.L., Raboud J.M., Montaner J.S.G., Wynhoven B.,
RA Brumme Z.L., Mo T., Smaill F., Rouleau D., Gill J., Schlech W., Gough K.,
RA Rachlis A., Cameron B., Lapointe N., Trottier B., Shafran S.,
RA Harrigan P.R.;
RT "Assay of HIV gp-41 amino acid sequence to identify baseline variation and
RT development of mutations in patients failing enfuvirtide.";
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; DQ076967; AAZ84373.1; -; Genomic_RNA.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR000328; GP41-like.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Viral envelope protein {ECO:0000313|EMBL:AAZ84373.1};
KW Virion {ECO:0000313|EMBL:AAZ84373.1}.
FT DOMAIN 19..207
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 206..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAZ84373.1"
FT NON_TER 326
FT /evidence="ECO:0000313|EMBL:AAZ84373.1"
SQ SEQUENCE 326 AA; 37398 MW; 5FC9681EB824E8B6 CRC64;
AVGIGALFLG FLGAAGSTMG AASIXLTVQA RLLLSGIAQQ QBNLLRAIEA QQHLLQLTVW
GIKQLQARVL ALERYLRDQQ LMGIWGCSGK LICTTTVPWN ASWSNKSLDA IWDNMTWMEW
EREIDNYTGV IYKLLEESQN QQEKNEKDLL ELGKWDSLWN WFNITNWLWY IKLFIMIVGG
LVGLRIIFAV LSIVNRVRQG YSPLPFQTRL PTPRGPDRPE GIXEEGGDRD RDRSXPLVNG
FLAIIWIDLR SLFLFSYHRL RDLLLIXTRI VELLGRRGWE ALKYWWNLLQ YWSQELKNSA
VSLLNVTAIA VAEGTDRIIE VLQRIG
//
