ID Q1AIY3_9HIV1 Unreviewed; 327 AA.
AC Q1AIY3;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AAZ84229.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AAZ84229.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAZ84229.1}
RP NUCLEOTIDE SEQUENCE.
RA Loutfy M.R., Walmsley S.L., Raboud J.M., Montaner J.S.G., Wynhoven B.,
RA Brumme Z.L., Mo T., Smaill F., Rouleau D., Gill J., Schlech W., Gough K.,
RA Rachlis A., Cameron B., Lapointe N., Trottier B., Shafran S.,
RA Harrigan P.R.;
RT "Assay of HIV gp-41 amino acid sequence to identify baseline variation and
RT development of mutations in patients failing enfuvirtide.";
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; DQ076823; AAZ84229.1; -; Genomic_RNA.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR000328; GP41-like.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Viral envelope protein {ECO:0000313|EMBL:AAZ84229.1};
KW Virion {ECO:0000313|EMBL:AAZ84229.1}.
FT DOMAIN 20..209
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 209..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAZ84229.1"
FT NON_TER 327
FT /evidence="ECO:0000313|EMBL:AAZ84229.1"
SQ SEQUENCE 327 AA; 37592 MW; 18E029BAACF67E47 CRC64;
AVGALGAMFL GFLGAAGSTM GAASMALTVQ ARQLLSGIVQ QQNNLLRAIE AQQHLLQLTV
WGIKQLQARV LAVERYLKDQ QLLGIWGCSG KLICTTAVPW NTSWSNKSLD QIWNNMTWME
WEKEIDNYTX LIYTLIEZSQ NQQEKNEQEL LELDXWAXLW NWFDISXWLW YIKIFIMIVG
GLIGLRIVFA XLSIVNRVRQ GYSPLSFQTY XPAPRGPDRP EGIEEEGGDR DRDRSNRLVH
GFLALIWDDL RSLCLFSYHR LRDLLLIVTR IVEXXGRRGW EILKYWWNLL QYWSQEIKNS
AVSLLNATAI AVAEGTDRII EAAQRIF
//
