ID Q1AX04_RUBXD Unreviewed; 678 AA.
AC Q1AX04;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN OrderedLocusNames=Rxyl_1108 {ECO:0000313|EMBL:ABG04074.1};
OS Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129 / PRD-1).
OC Bacteria; Actinomycetota; Rubrobacteria; Rubrobacterales; Rubrobacteraceae;
OC Rubrobacter.
OX NCBI_TaxID=266117 {ECO:0000313|EMBL:ABG04074.1, ECO:0000313|Proteomes:UP000006637};
RN [1] {ECO:0000313|EMBL:ABG04074.1, ECO:0000313|Proteomes:UP000006637}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 9941 / NBRC 16129 / PRD-1
RC {ECO:0000313|Proteomes:UP000006637};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., da Costa M.S.,
RA Rainey F.A., Empadinhas N., Jolivet E., Battista J.R., Richardson P.;
RT "Complete sequence of Rubrobacter xylanophilus DSM 9941.";
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
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DR EMBL; CP000386; ABG04074.1; -; Genomic_DNA.
DR RefSeq; WP_011564092.1; NC_008148.1.
DR AlphaFoldDB; Q1AX04; -.
DR STRING; 266117.Rxyl_1108; -.
DR CAZy; GT51; Glycosyltransferase Family 51.
DR KEGG; rxy:Rxyl_1108; -.
DR eggNOG; COG0744; Bacteria.
DR HOGENOM; CLU_006354_2_4_11; -.
DR OrthoDB; 9766909at2; -.
DR PhylomeDB; Q1AX04; -.
DR Proteomes; UP000006637; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000006637};
KW Transferase {ECO:0000313|EMBL:ABG04074.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 75..252
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 340..587
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 678 AA; 73994 MW; 037F3783E0133233 CRC64;
MNPRFETGTE SKGRRPGGLL ALLRAAFNAA LLAVAAALVL LLGAYVYALE RYGEGISRRY
PALPEDSYVY SADGERVGVI PASQRRRTVP FEELGPYLPR AVVAVEDRRF YEHAGVDPEG
VLRAAWTDLR AWEVQEGGST ITEQLVKNLY IPEEERFEVS FWRRLLQACL AHAYEQRHTK
REILTAYLNA VYFGRGAYGA EAAARAYFGK SARELDLSEA AALAGFLHAP SSYGRGGEER
AEDRRDAVLR LMRGQGVISG AQYRRAVSRE LRFSPPEGRE DPVYEPFLER VRREVEEHLG
EEALRRGGLR IRTTLDPRLQ RVAAASAADT LYAPGDPSAA VVSVEPQSGA IKALWGREGD
FNLALDARRQ PGSAFKPVVL ATALKEGISP YSTYLSGGLS LEFRGEEYVV NNYGYEERGE
ISLADAMAVS DNTVFVRLAM DVGLEEVART ARELGIRSPV EPYPSTAIGG LGVGVSPLEM
ASAYATFAGG GVYREPYAVE EIRREAYGGG ETLYDHRVSG RRVLGGNQAA AVTDVLRGVV
ERGTASRYRD LDAELGRPSA GKTGTSDGFA DAWYAGYTPQ LATAVWVGYP EGRRSMAGVH
GIEEVGGETL PLDIWAAYMR EATRGEPVWG FREPDYGKFR VVDRAYGGPS GEAVALASSL
QSRIRAMVDE ALREAFGG
//
