ID NUOH_YERPN Reviewed; 325 AA.
AC Q1CHQ7; C4GV68;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 01-MAY-2013, entry version 55.
DE RecName: Full=NADH-quinone oxidoreductase subunit H;
DE EC=1.6.99.5;
DE AltName: Full=NADH dehydrogenase I subunit H;
DE AltName: Full=NDH-1 subunit H;
GN Name=nuoH; OrderedLocusNames=YPN_2144; ORFNames=YP516_2393;
OS Yersinia pestis bv. Antiqua (strain Nepal516).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Yersinia.
OX NCBI_TaxID=377628;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nepal516;
RX PubMed=16740952; DOI=10.1128/JB.00124-06;
RA Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F.,
RA Vergez L.M., Worsham P., Chu M.C., Andersen G.L.;
RT "Complete genome sequence of Yersinia pestis strains Antiqua and
RT Nepal516: evidence of gene reduction in an emerging pathogen.";
RL J. Bacteriol. 188:4453-4463(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L.,
RA Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C.,
RA Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C.,
RA Brettin T.S.;
RT "Yersinia pestis Nepal516A whole genome shotgun sequencing project.";
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-
CC sulfur (Fe-S) centers, to quinones in the respiratory chain. The
CC immediate electron acceptor for the enzyme in this species is
CC believed to be ubiquinone. Couples the redox reaction to proton
CC translocation (for every two electrons transferred, four hydrogen
CC ions are translocated across the cytoplasmic membrane), and thus
CC conserves the redox energy in a proton gradient. This subunit may
CC bind ubiquinone (By similarity).
CC -!- CATALYTIC ACTIVITY: NADH + quinone = NAD(+) + quinol.
CC -!- SUBUNIT: NDH-1 is composed of 13 different subunits. Subunits
CC NuoA, H, J, K, L, M, N constitute the membrane sector of the
CC complex (By similarity).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
CC protein (Potential).
CC -!- SIMILARITY: Belongs to the complex I subunit 1 family.
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DR EMBL; CP000305; ABG18473.1; -; Genomic_DNA.
DR EMBL; ACNQ01000013; EEO76196.1; -; Genomic_DNA.
DR RefSeq; YP_648073.1; NC_008149.1.
DR ProteinModelPortal; Q1CHQ7; -.
DR STRING; 377628.YPN_2144; -.
DR EnsemblBacteria; ABG18473; ABG18473; YPN_2144.
DR EnsemblBacteria; EEO76196; EEO76196; YP516_2393.
DR GeneID; 4123781; -.
DR KEGG; ypn:YPN_2144; -.
DR PATRIC; 18603824; VBIYerPes46733_2572.
DR eggNOG; COG1005; -.
DR HOGENOM; HOG000228276; -.
DR KO; K00337; -.
DR OMA; VGEYINI; -.
DR ProtClustDB; PRK06076; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050136; F:NADH dehydrogenase (quinone) activity; IEA:EC.
DR GO; GO:0048038; F:quinone binding; IEA:UniProtKB-KW.
DR HAMAP; MF_01350; NDH1_NuoH; 1; -.
DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR PANTHER; PTHR11432; PTHR11432; 1.
DR Pfam; PF00146; NADHdh; 1.
DR PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Complete proteome; Membrane; NAD;
KW Oxidoreductase; Quinone; Transmembrane; Transmembrane helix;
KW Ubiquinone.
FT CHAIN 1 325 NADH-quinone oxidoreductase subunit H.
FT /FTId=PRO_0000298860.
FT TRANSMEM 11 31 Helical; (Potential).
FT TRANSMEM 81 101 Helical; (Potential).
FT TRANSMEM 114 134 Helical; (Potential).
FT TRANSMEM 154 174 Helical; (Potential).
FT TRANSMEM 186 206 Helical; (Potential).
FT TRANSMEM 237 257 Helical; (Potential).
FT TRANSMEM 265 285 Helical; (Potential).
FT TRANSMEM 304 324 Helical; (Potential).
SQ SEQUENCE 325 AA; 36185 MW; 4D1EADD74724A7DD CRC64;
MSWFTPELIE ILISVLKAVV ILLVVVTCGA FMSFGERRLL GLFQNRYGPN RVGWGGSLQL
VADMIKMFFK EDWVPRFSDR AIFTLAPVIA FTSLLLSFAI VPVSPTWAVA DLNIGILFFL
MMAGLAVYAV LFAGWASNNK YSLLGAMRAS AQTLSYEVFL GLSLMGVVAQ AGSFNMQDIV
NSQEHVWNVI PQFFGFLTFA IAGVAVCHRH PFDQPEAEQE LADGYHIEYS GMKFGLFFVG
EYIGIVTVSA LIVTLFFGGW QGPFLPPFIW FALKTAFFMV MFILIRASLP RPRYDQVMSF
GWKVCLPLTL LNLLATAAVI LYNAQ
//
