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Database: UniProt
Entry: Q1CMJ1
LinkDB: Q1CMJ1
Original site: Q1CMJ1 
ID   RLMG_YERPN              Reviewed;         395 AA.
AC   Q1CMJ1; C4GP13;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   01-OCT-2014, entry version 57.
DE   RecName: Full=Ribosomal RNA large subunit methyltransferase G {ECO:0000255|HAMAP-Rule:MF_01859};
DE            EC=2.1.1.174 {ECO:0000255|HAMAP-Rule:MF_01859};
DE   AltName: Full=23S rRNA m2G1835 methyltransferase {ECO:0000255|HAMAP-Rule:MF_01859};
DE   AltName: Full=rRNA (guanine-N(2)-)-methyltransferase RlmG {ECO:0000255|HAMAP-Rule:MF_01859};
GN   Name=rlmG {ECO:0000255|HAMAP-Rule:MF_01859};
GN   OrderedLocusNames=YPN_0457; ORFNames=YP516_0473;
OS   Yersinia pestis bv. Antiqua (strain Nepal516).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Yersinia.
OX   NCBI_TaxID=377628;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nepal516;
RX   PubMed=16740952; DOI=10.1128/JB.00124-06;
RA   Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F.,
RA   Vergez L.M., Worsham P., Chu M.C., Andersen G.L.;
RT   "Complete genome sequence of Yersinia pestis strains Antiqua and
RT   Nepal516: evidence of gene reduction in an emerging pathogen.";
RL   J. Bacteriol. 188:4453-4463(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L.,
RA   Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C.,
RA   Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C.,
RA   Brettin T.S.;
RT   "Yersinia pestis Nepal516A whole genome shotgun sequencing project.";
RL   Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Specifically methylates the guanine in position 1835
CC       (m2G1835) of 23S rRNA. {ECO:0000255|HAMAP-Rule:MF_01859}.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + guanine(1835) in 23S
CC       rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(1835) in 23S
CC       rRNA. {ECO:0000255|HAMAP-Rule:MF_01859}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01859}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. RlmG
CC       family. {ECO:0000255|HAMAP-Rule:MF_01859}.
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DR   EMBL; CP000305; ABG16789.1; -; Genomic_DNA.
DR   EMBL; ACNQ01000006; EEO78245.1; -; Genomic_DNA.
DR   PIR; AB0073; AB0073.
DR   RefSeq; YP_646389.1; NC_008149.1.
DR   ProteinModelPortal; Q1CMJ1; -.
DR   STRING; 377628.YPN_0457; -.
DR   EnsemblBacteria; ABG16789; ABG16789; YPN_0457.
DR   EnsemblBacteria; EEO78245; EEO78245; YP516_0473.
DR   GeneID; 4125798; -.
DR   KEGG; ypn:YPN_0457; -.
DR   PATRIC; 18599929; VBIYerPes46733_0650.
DR   eggNOG; COG2813; -.
DR   HOGENOM; HOG000246323; -.
DR   KO; K00564; -.
DR   OMA; DIGARIM; -.
DR   OrthoDB; EOG67X1ZC; -.
DR   BioCyc; YPES377628:GIXK-489-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0052916; F:23S rRNA (guanine(1835)-N(2))-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   Gene3D; 3.40.50.150; -; 1.
DR   HAMAP; MF_01859; 23SrRNA_methyltr_G; 1.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR017237; rRNA_m2G-MeTrfase_RsmD.
DR   InterPro; IPR029063; SAM-dependent_MTases-like.
DR   InterPro; IPR007848; Small_mtfrase_dom.
DR   Pfam; PF05175; MTS; 1.
DR   PIRSF; PIRSF037565; RRNA_m2G_Mtase_RsmD_prd; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Methyltransferase; rRNA processing;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    395       Ribosomal RNA large subunit
FT                                methyltransferase G.
FT                                /FTId=PRO_0000366543.
SQ   SEQUENCE   395 AA;  43841 MW;  E74D17002BA7E5E2 CRC64;
     MSQLDLGTQS LELERFPPQE NSNTLQAWEA ADEYLLQNID LSQIDGRPVL VFNDQFGTLA
     CALHAYRPFS SSDSYMSQLA TAHNLRLNHL DESAVTLLSS VDDLPEAPKL VVIKIPKALA
     LLEHQLRALR RVVAPDTVII AGAKSRDVHN STLQLFEKIL GPTKTTLAWK KARLIHCEVA
     DIPLADAPET IDWPLPNTDY IIHNHANVFS RNNLDIGARF FMEILPYDVT GKIADLGCGN
     GVVGLIALEQ NPLAEMLFVD ESYMAVASSE LNITVNRPQD LSRCEFMVSH GLAGVERESL
     QLVLCNPPFH QQHAVSDHVA WQMFCDAKRC LKAGGELMIV GNRHLDYFHK LKRLFGNCET
     LDSNQKFMVL KSVKQASSRS EGGGSGSLDM SYSDF
//
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