ID Q1CT22_HELPH Unreviewed; 507 AA.
AC Q1CT22;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=HPAG1_0833 {ECO:0000313|EMBL:ABF84900.1};
OS Helicobacter pylori (strain HPAG1).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=357544 {ECO:0000313|EMBL:ABF84900.1, ECO:0000313|Proteomes:UP000008835};
RN [1] {ECO:0000313|EMBL:ABF84900.1, ECO:0000313|Proteomes:UP000008835}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HPAG1 {ECO:0000313|EMBL:ABF84900.1,
RC ECO:0000313|Proteomes:UP000008835};
RX PubMed=16788065; DOI=10.1073/pnas.0603784103;
RA Oh J.D., Kling-Baeckhed H., Giannakis M., Xu J., Fulton R.S., Fulton L.A.,
RA Cordum H.S., Wang C., Elliott G., Edwards J., Mardis E.R., Engstrand L.G.,
RA Gordon J.I.;
RT "The complete genome sequence of a chronic atrophic gastritis Helicobacter
RT pylori strain: evolution during disease progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:9999-10004(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP000241; ABF84900.1; -; Genomic_DNA.
DR RefSeq; WP_011550052.1; NC_008086.1.
DR AlphaFoldDB; Q1CT22; -.
DR SMR; Q1CT22; -.
DR REBASE; 13126; M.HpyHORF833P.
DR KEGG; hpa:HPAG1_0833; -.
DR HOGENOM; CLU_013049_0_1_7; -.
DR Proteomes; UP000008835; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004546; Restrct_endonuc_T1M.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR NCBIfam; TIGR00497; hsdM; 1.
DR PANTHER; PTHR42933:SF1; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); 1.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ABF84900.1};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ABF84900.1}.
FT DOMAIN 2..153
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 166..473
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 507 AA; 57471 MW; CBFA6355712CDB0A CRC64;
MHNTIWKVAN ELRGSVDGWD FKQYVLGILF YRYISENMTH YINKKERKRD PDFDYAKLSD
EEAKHARKHL IEEKDFFIPP SALFCNALKN APHNEDLNVT LQNIFNEIEK SSLGTPSEEN
VKGLFADLDV NSNKLGSSHK NRVEKLTKIL EAIGGMQLGD YLKSGIDVFG DAYEYLMAMY
ASNAGKSGGE FFTPQEVSEL LAKITLHNQE SVNKVYDPCC GSGSLLLQFS KVLGDKNVSK
GYFGQEINLT TYNLCRINMF LHDINYTKFH IALGDTLLDP KHEDDEPFDA IVSNPPYSTK
WGGDNNPLLI NDERFSPAGV LAPKNAADLA FTMHMLSYLS NSGTAAIVEF PGVLYRGNAE
AKIREYLVKE NVIDCVIALP DNLFFGTNIA TCILVLKKNK KDDTTLFIDA SKEFVKEGKK
NKLKAHNREK ILQTYIERKE VKHFCALANM EQIQENDYNL SVNRYVEQED TKEAIDIKAL
NSEISQIVEK QSALRNRLDR IIKELEA
//
