ID Q1D4W0_MYXXD Unreviewed; 593 AA.
AC Q1D4W0;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE RecName: Full=protein-glutamate O-methyltransferase {ECO:0000256|ARBA:ARBA00012534};
DE EC=2.1.1.80 {ECO:0000256|ARBA:ARBA00012534};
GN Name=frzF {ECO:0000313|EMBL:ABF86899.1};
GN OrderedLocusNames=MXAN_4138 {ECO:0000313|EMBL:ABF86899.1};
OS Myxococcus xanthus (strain DK1622).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Myxococcaceae; Myxococcus.
OX NCBI_TaxID=246197 {ECO:0000313|EMBL:ABF86899.1, ECO:0000313|Proteomes:UP000002402};
RN [1] {ECO:0000313|EMBL:ABF86899.1, ECO:0000313|Proteomes:UP000002402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DK1622 {ECO:0000313|Proteomes:UP000002402};
RX PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S.,
RA Eisen J.A., Ronning C.M., Barbazuk W.B., Blanchard M., Field C.,
RA Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R.,
RA Miller N., Shvartsbeyn A., Sullivan S.A., Vaudin M., Wiegand R.,
RA Kaplan H.B.;
RT "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-
CC glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:24452, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:10311,
CC ChEBI:CHEBI:29973, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:82795; EC=2.1.1.80;
CC Evidence={ECO:0000256|ARBA:ARBA00001541};
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DR EMBL; CP000113; ABF86899.1; -; Genomic_DNA.
DR RefSeq; WP_011554141.1; NC_008095.1.
DR AlphaFoldDB; Q1D4W0; -.
DR SMR; Q1D4W0; -.
DR STRING; 246197.MXAN_4138; -.
DR EnsemblBacteria; ABF86899; ABF86899; MXAN_4138.
DR GeneID; 41361457; -.
DR KEGG; mxa:MXAN_4138; -.
DR eggNOG; COG0457; Bacteria.
DR eggNOG; COG1352; Bacteria.
DR HOGENOM; CLU_025854_4_0_7; -.
DR OrthoDB; 5377542at2; -.
DR Proteomes; UP000002402; Chromosome.
DR GO; GO:0008983; F:protein-glutamate O-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.155.10; Chemotaxis receptor methyltransferase CheR, N-terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022642; CheR_C.
DR InterPro; IPR000780; CheR_MeTrfase.
DR InterPro; IPR036804; CheR_N_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR24422; CHEMOTAXIS PROTEIN METHYLTRANSFERASE; 1.
DR PANTHER; PTHR24422:SF19; CHEMOTAXIS PROTEIN METHYLTRANSFERASE; 1.
DR Pfam; PF01739; CheR; 1.
DR Pfam; PF13432; TPR_16; 1.
DR PRINTS; PR00996; CHERMTFRASE.
DR SMART; SM00138; MeTrc; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF47757; Chemotaxis receptor methyltransferase CheR, N-terminal domain; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50123; CHER; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ABF86899.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002402};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ABF86899.1}.
FT DOMAIN 1..276
FT /note="CheR-type methyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50123"
FT REPEAT 457..490
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 593 AA; 64669 MW; B38BA5F481A082B9 CRC64;
MLTASQKVLQ QLAALLLERA GLKITPDGFH SLRLALSARM PVLGLEEPEH YIQRLTGAGG
EEELRSLLPL VTVGHTEFFR DAKQFRALEK SVLPDLVSRS RREMRKVSIW SAGCATGEEP
YSLAMVLAEL GALSLEVDLW ATDLNLAAVE AAKQGRFTSR RAISINQARL TRFFKPVEEG
YEALPALREY IRFDGQNLAV PVFDKVALSS LDLILCRNVI IYFDLPTIRG LMDRFLAALR
PGGLLFLGYS ESLFKVYDRF EMIEVDGAFV YRRPLNDKSM RAPPLRITPY PGEPDVAARR
PVPADAFTAD LRKRMLPEDV PLTTRLPAVS ASSVAAPGSP SVTLPALGAS SSPRSVVPGR
LPAVSPHSPL PAIAARSRVT AELPTVGSVD SARPRITTEL PAVATTPRAP TVEVPAWPTL
LPPAERLAMA VRKMAQGDFS AAIAGVQRLL ADEPSDLDGL LTLGNLFSLT GRIPEAREAF
AQAIQREPLC VEARVFGGVA ALQAGELSEA RSELSKALFL EPTLAIGHYL LAQVHERTQD
HEAARRSYRN AIAQLRFPQR PLAGHYPEMP DSADAISRAA RYALAALEEQ PLR
//
