ID Q1D6B8_MYXXD Unreviewed; 4567 AA.
AC Q1D6B8;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 122.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:ABF86985.1};
GN OrderedLocusNames=MXAN_3618 {ECO:0000313|EMBL:ABF86985.1};
OS Myxococcus xanthus (strain DK1622).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Myxococcaceae; Myxococcus.
OX NCBI_TaxID=246197 {ECO:0000313|EMBL:ABF86985.1, ECO:0000313|Proteomes:UP000002402};
RN [1] {ECO:0000313|EMBL:ABF86985.1, ECO:0000313|Proteomes:UP000002402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DK1622 {ECO:0000313|Proteomes:UP000002402};
RX PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S.,
RA Eisen J.A., Ronning C.M., Barbazuk W.B., Blanchard M., Field C.,
RA Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R.,
RA Miller N., Shvartsbeyn A., Sullivan S.A., Vaudin M., Wiegand R.,
RA Kaplan H.B.;
RT "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP000113; ABF86985.1; -; Genomic_DNA.
DR RefSeq; WP_011553636.1; NC_008095.1.
DR STRING; 246197.MXAN_3618; -.
DR EnsemblBacteria; ABF86985; ABF86985; MXAN_3618.
DR GeneID; 41360956; -.
DR KEGG; mxa:MXAN_3618; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_223631_0_0_7; -.
DR OrthoDB; 9757540at2; -.
DR Proteomes; UP000002402; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd12117; A_NRPS_Srf_like; 2.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 4.
DR Gene3D; 3.40.50.980; -; 8.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 4.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 4.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 4.
DR Pfam; PF13193; AMP-binding_C; 4.
DR Pfam; PF00668; Condensation; 4.
DR Pfam; PF00550; PP-binding; 4.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 4.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 8.
DR PROSITE; PS00455; AMP_BINDING; 4.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002402}.
FT DOMAIN 1024..1098
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2085..2160
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3150..3224
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4213..4288
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2067..2089
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4567 AA; 502554 MW; 65CB58A47E40ED3E CRC64;
MTDISRALEQ LSPSQRALLD LLLQEQQSAQ PHAAAPVLVR RESNEPAPAS FPQQRLWVLH
ELDPSSMAAY NVHVSVEFFG RLDRALLTRC VNEVVRRHES LRTTLRSHGG DPVQVVAPSL
ELTLPEEDLS ALSLEAQGDE VRRRIIAEAN FEFDLSAGPL LRVGILRLDA QHALVLLTLH
HSVTDQWSLG VFLQELMALY KAFEEGQPSP LPELELQYPD YARWQREQFE TRELAGQLDY
WRRQLTPQPS ALVVPSDHPR PALKTYRGGW HHFRLEPELA RKLKQLAQKE GATLFMVLMA
AYQTLLHRYS GQQDFAVGSP VANRRAPELE PLIGFFVNML VMRADASGDP TFRSFLHRVR
QVCLDAYSHQ DVPFDKLVEE LQPPRDPSRN PFFEAVFVLQ NVPQPALRIP GLLARYVELD
LGVSQFDLLM ELREDRPDRF IGRIEYCADL FDAKTVERMD RHYVRLLESV VENADQRLSE
LPLLRTEERQ QLLVDWNAKS TAFPRETPIH SLFSEQAARA PDAVALVSGE TLVTYAELER
RANQLAHHLR TYGVSRGTRV GLCLERSPDM VVGLLAILKA GGAYVPIDHH YPAERISLLL
QEAGIGVLVT TKPLAEGLPA SNSKHVCVDT DADVITALPH DAPLPATVGG DDLAYVMFTS
GSTGRPKGVC IPHRAVSRLV LANPFIHFGP DEVFLQLAPV AFDASTLELW GALLHGARLV
LAPPHTPSLD ELAALLTHHR VSTLWLTAAL FEQMVLHQGN ALAGVRQVLA GGDVLPPLRV
RQHLERIPLG AVLVNGYGPT ENTTFSATHS LRAGEAFGTS VPIGRPLGHS TAYVLDSRME
PVPVGVPGEL FVGGDGLAWG YLSRPELTAE KFLPHPFSSA PGARLYRTGD RVRWRADGSL
EFLGRSDFQV KVRGFRIELG EIESVLQQAP GVQEAVVLAR EDAPGDKRLV AYFVPTAAAR
SEEQAANAVG GIRTFLKARL PEYMLPAVFM PLEVLPLSPN GKVDRKALPA PYADLNRTGT
PFEAPRNASE QTLADIWAEV LGLRQVGIDD SFFELGGDSI RSIQVIAKLR EQGLELPTLE
LLQHPTIREL TGVIKATSVA PAGQIAPFSL VSEADRQRLP EDVEDAYPLA ALQSGMLFES
ALDASAGIYH DMFSFHVEMA LNEPLLQQAF RELFARHAIL RTSFHLDGHE EPLQLVHREV
EPPLKFEDLQ HLEAPQQTAY LQVSAEKERV QPFTWNQAPL MRLCVHRRSE TTVQLTIVFH
HAILDGWSAA TLLSELFGRY LELLEGTETP AAPSPAATYR QFVALERETQ NSHESERFWL
RRMDGVDAAS PRPLRSRDDE RVLHTHDVRI PGPLQQALLR VAHEAGVSLK TVLLAVHLRV
RGFVEGSTSV VTGIVTNGRP EVVDGERMIG LFLNSVPFPV TLPGGTWLEL IQQVAKHEQE
LMPHRRYPMA RLQQKRGGQP LFDTLFNFIH FHVAGGLSQQ KGLRFVDEML GAAWMELPLG
VTFTQDPDTS SLSVSIATTG TRHEAERTRE LGQYYLRALE AVAAGPSGRY EQAALLPPVD
RDTLLEAWNA TRREAAWEGC LHERFEDRAA LSPDALAVLD DEHSLTYAEL NRRANQLAWA
LRTRGVGPEV RVGLCMERAV DMVVGVLAIL KAGGAYVPMD PAYPAQRLAY MVSDSNVSCM
LTQQRVADKI AGHKVEVLCV DDAGLVNGSR DASNPPRLSR PQHLAYVIYT SGSTGMPKGV
MVQHASVMNL RAALAATAYA GVGKPLRVSL NASLSFDASV QQLVQLADGH ALCVVSQATR
EDTRLMLAWL ERHSVDVLDC APSQLRLLLD EGLAAHSPLR VLAGGEALDE ALWARLSAHP
HIECFNVYGP TECTVDSTLR PVRGASLPPS LGGPLANAQT YVLDAYLQPV PVGVPGELYI
GGAGLARGYL NRPELTADRF IPNPFSTASG ARLYRTGDRA RWLPQGELEF LGRIDFQVKV
RGFRIELGEI ESALRQHPAV RDTVVLVRED TPGLQRLVAY VVAEAEATTV VDSGTFRPFL
KERLPEHMVP SAFVTLEALP LTPNGKLDRK ALPAPEAPRS AATRPLSTET ERRVAAHWAT
LLHVETVNAE DDFFALGGHS LLATQLVTRL RQDFDVDLPL RALFEQSTVA ALAARLDSER
ARGTASALPP IRAAPRDRPL PQSFVQQRLW VMEQLTPDTA TYNNPAAVAI DGALDARAME
QSLLRVVQRH EALRTTFRNE GDLPVQVVHP IKTLELPITD ISTLPEGERD ARARQLANEE
AHLPFNLVRG PLFRARLLRL ASDRHVLFVT MHHIVSDGWS VGVLVREVAE GYEAAVQGRD
AQLPPLSVQY ADYALWQREW MQGPVLDSRL NYWREQLDGA PAALELPTDR PRPAVQTYRG
ALLPVRMPAK LSEAVTALAR RQEATPFMVL LATWQLLLSR YSGQQDLCVG SPIAGRTRPE
LEGLIGFFVN TLVFRARMSP ELPFRELLAQ AKAAALGASE HQDVPFEKLV EVLQPARDPS
RSPLFQVTFT LQNTPPVRLE LQGLSLHVLE TELETVKFDL SLLLEETLEG LSGALNYNTD
LFDASTAARM MGHFRTLLEA IVTDENQRLV ELPLLRTEER QQLLVDWNAT SAVFPRDTPT
HVLFSDQATR TPDAMALISG ESVVTYVELD RRSNQLAHHL RAYGVSRGTR VGLCLERSPD
MVVGLLAILK AGGAYVPIDH HYPAERISLL LQEAGVSVFV TQESLADELP SSGGLMVCVD
TDADLIAALP HGAPPSADVG GDDLAYVMFT SGSTGRPKGV CIPHRAVSRL VLANPFIHFG
PDEVFLQLAP VAFDASTLEL WGALLHGARL VLAPPHTPSL DELAALLTHH RVSTLWLTAA
LFEQMVLHQG NALAGVRQVL AGGDVLPPLR VRQHLERIPL GAVLVNGYGP TENTTFSATH
SLRAGEAFGT SVPIGRPLGH STAYVLDSRM EPVPVGVPGE LFVGGDGLAW GYLSRPELTA
EKFLPHPFSS APGARLYRTG DRVRWRADGS LEFLGRSDFQ VKVRGFRIEL GEIESVLQQA
PGVQEAVVLA REDSPGDKRL VAYVVGEDGV ESVDARALRD HVLRKLPEYL VPAIFIPMES
LPLSANGKVD RKALPAPDAD RALTGASFEA PRDASEQAIA DIWAAVLGLR QLGIDDNFFE
LGGDSIRSIQ VIAKLRERGL ELPIMELLQH PTIRQLSGVV KHAGESSPAA HDVAPFGFVS
EADRKRLPED VEDAFPLAAL QSGMLFESAL DASAGIYHDM FSFHLELKLD EPLLRQAFQE
LIARHAILRT SFHLDGYEEP LQLVHREVRP PLRIEDLRHL EPSQQDAFLR EWVEAERIKP
FEWTQAPLLH VAVHRRTDRG VQLTIVFHHA ILDGWSAATL FSELFGRYLE LQDDSNAPPA
QPLAATYRQF IALEREAQQS AESERFWLKR MEAMDSPGPR PNRARDGERV LHNHEVRIPN
SLQQALVRVA HEAGVSLKTV LLAVHLRVRG FVEGSTSVVT GIVTNGRPEV VDGERMIGLF
LNSVPFPVTL PGGTWMELIQ QVAKHEQELM PHRRYPMARL QQKRGGQPLF DTLFNFIHFH
VAGGLSQQKG LRFVDEMLGA AWMELPLGVT FTQDPDTSSL SISISTTGTR HEAERTRELG
QYYLRALEAV AAGPGGRYDQ AALLPPADRD TLLGAWNATL REVAWEGCLH ERFEDRAALS
PDSLAVLDDE HSLTYAELNR RANQLAWALR TRGVGPEVRV GLCMERSVDM VVGVLAILKA
GGAYVPMDPA YPAQRLAYMV SDSNVGCVLT QQRVADKLAG HKVEVLCVDD AAPTNEPRSE
SNPPRLSEPE HLAYVIYTSG STGKPKGVMV QHASVMNLRA ALAAAAYAGM DKPLRVSLNA
SLSFDASVQH LVQLADGHAL CVVPQTARED ARIMLAWLEQ NDVDVLDCAP SLLRLLLDEG
LAAHRPLRVL AGGEALDEAL WARLSAHPRI ECFNVYGPTE CTVDSTLRPV RGASLPPSLG
GPLANAQTYV LDAYLQPVPV GVPGELYIGG AGLARGYLNR PELTADRFIP NPFSTASGAR
LYRTGDRARW LPQGELEFLG RIDFQVKLRG FRIELGEIES ALRQHPAVRD TVVLVREDTP
GLQRLVAYVV AEPAATVDSG TFRPFLKERL PEHMMPSAFV TLEALPLNTS GKVDRRALPL
PEETSPRHEV YVPPRDAYEL ELARLFEELL GVSPISAKSD FFELGGHSLL AVRLLSMLRA
RTGRTLPAAA LFQTPTVEGL AAFLRREPAL WTPLVPIQRS GSRLPFFCVH PVGGTVFCYT
ELARRLGPDQ PFYGLQAQGL EGTLPPLESI DSMAASYVDA IRTLQPQGPY RLGGWSLGAV
IAFEMARLLH QRGETVEVLA LIEPSSTSLA QGVTTNDDSA AATMFALDLA LTAGIASAMT
VEGAVSDPQA LVERVLQEDR EAGVFVPDAG MEHFHALLRV FTANVRALQQ HTLGTFPGSL
TVLRGSDTEL EPSEAEDRGW SRHATQLAVH VVQGDHYTVL RLPGADALAR VLTELLARAD
TTESVSQ
//
