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Database: UniProt
Entry: Q1DHR3
LinkDB: Q1DHR3
Original site: Q1DHR3 
ID   NACA_COCIM              Reviewed;         205 AA.
AC   Q1DHR3; J3K086;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   01-OCT-2014, entry version 41.
DE   RecName: Full=Nascent polypeptide-associated complex subunit alpha;
DE            Short=NAC-alpha;
DE   AltName: Full=Alpha-NAC;
GN   Name=EGD2; ORFNames=CIMG_10150;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; mitosporic Onygenales; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J.,
RA   Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E.,
RA   Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M.,
RA   Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N., Orbach M.J.,
RA   Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens
RT   Coccidioides and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Component of the nascent polypeptide-associated complex
CC       (NAC), a dynamic component of the ribosomal exit tunnel,
CC       protecting the emerging polypeptides from interaction with other
CC       cytoplasmic proteins to ensure appropriate nascent protein
CC       targeting. The NAC complex also promotes mitochondrial protein
CC       import by enhancing productive ribosome interactions with the
CC       outer mitochondrial membrane and blocks the inappropriate
CC       interaction of ribosomes translating non-secretory nascent
CC       polypeptides with translocation sites in the membrane of the
CC       endoplasmic reticulum. EGD2 may also be involved in transcription
CC       regulation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of the nascent polypeptide-associated complex (NAC),
CC       consisting of EGD2 and EGD1. NAC associates with ribosomes via
CC       EGD1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Note=Predominantly cytoplasmic, may also
CC       transiently localize to the nucleus. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NAC-alpha family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 NAC-A/B (NAC-alpha/beta) domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00507}.
CC   -!- SIMILARITY: Contains 1 UBA domain. {ECO:0000305}.
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DR   EMBL; GG704915; EAS27236.2; -; Genomic_DNA.
DR   RefSeq; XP_001239128.1; XM_001239127.1.
DR   RefSeq; XP_001249276.1; XM_001249275.1.
DR   ProteinModelPortal; Q1DHR3; -.
DR   GeneID; 4558192; -.
DR   GeneID; 4568317; -.
DR   KEGG; cim:CIMG_10150; -.
DR   KEGG; cim:CIMG_10438; -.
DR   KO; K03626; -.
DR   OrthoDB; EOG7ZD27F; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR016641; EGD2/NACA.
DR   InterPro; IPR002715; Nas_poly-pep-assoc_cplx_dom.
DR   InterPro; IPR000449; UBA/Ts_N.
DR   PANTHER; PTHR21713; PTHR21713; 1.
DR   Pfam; PF01849; NAC; 1.
DR   Pfam; PF00627; UBA; 1.
DR   PIRSF; PIRSF015901; NAC_alpha; 1.
DR   PROSITE; PS51151; NAC_AB; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Nucleus; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN         1    205       Nascent polypeptide-associated complex
FT                                subunit alpha.
FT                                /FTId=PRO_0000273486.
FT   DOMAIN       48    113       NAC-A/B. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00507}.
FT   DOMAIN      166    205       UBA.
SQ   SEQUENCE   205 AA;  22081 MW;  05F26F97F7F05DD4 CRC64;
     MANPRVEELP DEEVPKTTVE DAGESSESEA EAAEEPTIPG GAAITVHSRN EKKARKAIGK
     LGLKHVPGIT RVTLRRPKNI LFVINQPDVY RSPSSNTWII FGEAKIEDLN SQAQASAAQQ
     LSAAEAAGNG EHAGHEHIDL GKGKAPETEK KEEEEEEEGE VDETGLEAKD IELVMAQANV
     SRSKAIKALK ENDNDIVNSI MALSV
//
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