ID NACA_COCIM Reviewed; 205 AA.
AC Q1DHR3; J3K086;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 01-MAY-2013, entry version 37.
DE RecName: Full=Nascent polypeptide-associated complex subunit alpha;
DE Short=NAC-alpha;
DE AltName: Full=Alpha-NAC;
GN Name=EGD2; ORFNames=CIMG_10150;
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; mitosporic Onygenales; Coccidioides.
OX NCBI_TaxID=246410;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS;
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J.,
RA Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E.,
RA Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M.,
RA Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N., Orbach M.J.,
RA Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens
RT Coccidioides and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=RS;
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- FUNCTION: Component of the nascent polypeptide-associated complex
CC (NAC), a dynamic component of the ribosomal exit tunnel,
CC protecting the emerging polypeptides from interaction with other
CC cytoplasmic proteins to ensure appropriate nascent protein
CC targeting. The NAC complex also promotes mitochondrial protein
CC import by enhancing productive ribosome interactions with the
CC outer mitochondrial membrane and blocks the inappropriate
CC interaction of ribosomes translating non-secretory nascent
CC polypeptides with translocation sites in the membrane of the
CC endoplasmic reticulum. EGD2 may also be involved in transcription
CC regulation (By similarity).
CC -!- SUBUNIT: Part of the nascent polypeptide-associated complex (NAC),
CC consisting of EGD2 and EGD1. NAC associates with ribosomes via
CC EGD1 (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC similarity). Note=Predominantly cytoplasmic, may also transiently
CC localize to the nucleus (By similarity).
CC -!- SIMILARITY: Belongs to the NAC-alpha family.
CC -!- SIMILARITY: Contains 1 NAC-A/B (NAC-alpha/beta) domain.
CC -!- SIMILARITY: Contains 1 UBA domain.
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DR EMBL; GG704915; EAS27236.2; -; Genomic_DNA.
DR RefSeq; XP_001239128.1; XM_001239127.1.
DR RefSeq; XP_001249276.1; XM_001249275.1.
DR ProteinModelPortal; Q1DHR3; -.
DR GeneID; 4558192; -.
DR GeneID; 4568317; -.
DR KEGG; cim:CIMG_10150; -.
DR KEGG; cim:CIMG_10438; -.
DR KO; K03626; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR016641; EGD2/NACA.
DR InterPro; IPR002715; Nas_poly-pep-assoc_cplx_dom.
DR InterPro; IPR000449; UBA/transl_elong_EF1B_N.
DR PANTHER; PTHR21713; PTHR21713; 1.
DR Pfam; PF01849; NAC; 1.
DR Pfam; PF00627; UBA; 1.
DR PIRSF; PIRSF015901; NAC_alpha; 1.
DR PROSITE; PS51151; NAC_AB; 1.
DR PROSITE; PS50030; UBA; FALSE_NEG.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Nucleus; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1 205 Nascent polypeptide-associated complex
FT subunit alpha.
FT /FTId=PRO_0000273486.
FT DOMAIN 48 113 NAC-A/B.
FT DOMAIN 166 205 UBA.
SQ SEQUENCE 205 AA; 22081 MW; 05F26F97F7F05DD4 CRC64;
MANPRVEELP DEEVPKTTVE DAGESSESEA EAAEEPTIPG GAAITVHSRN EKKARKAIGK
LGLKHVPGIT RVTLRRPKNI LFVINQPDVY RSPSSNTWII FGEAKIEDLN SQAQASAAQQ
LSAAEAAGNG EHAGHEHIDL GKGKAPETEK KEEEEEEEGE VDETGLEAKD IELVMAQANV
SRSKAIKALK ENDNDIVNSI MALSV
//
