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Database: UniProt
Entry: Q1G867
LinkDB: Q1G867
Original site: Q1G867 
ID   PYRC_LACDA              Reviewed;         425 AA.
AC   Q1G867;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2006, sequence version 1.
DT   19-FEB-2014, entry version 56.
DE   RecName: Full=Dihydroorotase;
DE            Short=DHOase;
DE            EC=3.5.2.3;
GN   Name=pyrC; OrderedLocusNames=Ldb2111;
OS   Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM
OS   20081).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=390333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11842 / DSM 20081;
RX   PubMed=16754859; DOI=10.1073/pnas.0603024103;
RA   van de Guchte M., Penaud S., Grimaldi C., Barbe V., Bryson K.,
RA   Nicolas P., Robert C., Oztas S., Mangenot S., Couloux A., Loux V.,
RA   Dervyn R., Bossy R., Bolotin A., Batto J.-M., Walunas T.,
RA   Gibrat J.-F., Bessieres P., Weissenbach J., Ehrlich S.D., Maguin E.;
RT   "The complete genome sequence of Lactobacillus bulgaricus reveals
RT   extensive and ongoing reductive evolution.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:9274-9279(2006).
CC   -!- CATALYTIC ACTIVITY: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-
CC       aspartate.
CC   -!- COFACTOR: Binds 2 zinc ions per subunit (By similarity).
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; (S)-dihydroorotate from bicarbonate: step 3/3.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the DHOase family. Type 2 subfamily.
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DR   EMBL; CR954253; CAI98849.1; -; Genomic_DNA.
DR   RefSeq; YP_619723.1; NC_008054.1.
DR   ProteinModelPortal; Q1G867; -.
DR   STRING; 390333.Ldb2111; -.
DR   EnsemblBacteria; CAI98849; CAI98849; Ldb2111.
DR   GeneID; 4084392; -.
DR   KEGG; ldb:Ldb2111; -.
DR   PATRIC; 22219609; VBILacDel123523_1859.
DR   eggNOG; COG0044; -.
DR   HOGENOM; HOG000219142; -.
DR   KO; K01465; -.
DR   OMA; HHLTLTE; -.
DR   OrthoDB; EOG6KHFW6; -.
DR   ProtClustDB; PRK09357; -.
DR   BioCyc; LDEL390333:GIXG-2080-MONOMER; -.
DR   UniPathway; UPA00070; UER00117.
DR   GO; GO:0004151; F:dihydroorotase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_00220_B; PyrC_type2_B; 1.
DR   InterPro; IPR006680; Amidohydro_1.
DR   InterPro; IPR004722; DHOase.
DR   InterPro; IPR002195; Dihydroorotase_CS.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; SSF51338; 2.
DR   TIGRFAMs; TIGR00857; pyrC_multi; 1.
DR   PROSITE; PS00483; DIHYDROOROTASE_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis;
KW   Zinc.
FT   CHAIN         1    425       Dihydroorotase.
FT                                /FTId=PRO_1000024087.
FT   METAL        56     56       Zinc 1 (By similarity).
FT   METAL        58     58       Zinc 1 (By similarity).
FT   METAL       138    138       Zinc 1; via carbamate group (By
FT                                similarity).
FT   METAL       138    138       Zinc 2; via carbamate group (By
FT                                similarity).
FT   METAL       175    175       Zinc 2 (By similarity).
FT   METAL       228    228       Zinc 2 (By similarity).
FT   METAL       301    301       Zinc 1 (By similarity).
FT   MOD_RES     138    138       N6-carboxylysine (By similarity).
SQ   SEQUENCE   425 AA;  46291 MW;  187D96BE7C71EB33 CRC64;
     MQTVIKNGTV YQNGRLIHAD VLIEDQKIKA IGTDLTGDKV IDATGKLVSP GLVDVHVHYR
     DPGQTYKEDI ETGSKAAAHG GFTTVGAMPN VTPVPDTPDL MKKMVQENKQ KGIVHIFQYG
     PITKNETTDE LPDYAALKKA GAFALSNDGH GVQTAQTMYL AMQEAKKNDL IVAAHAQDDS
     LFNHGIVNEG EKAKELNLPP VTELAETTQI ARDLLLAEKT GVHYHICHVS TKTSVELVRM
     AKACGINVTC EAAPHHLLLT EDDIPKDNGY YKMNPPLRSK EDQAALLVGL LDGTIDLIAT
     DHAPHAKQEK QGGMQNAAFG ITGSETAFST LYTKFVKEDK VFTLEQLLSW LSDQPAKVFG
     LKKAGVLEPG CPADVAIFDL EHETELKEKN YQSKGINTPF TGQKIYGATV MTMVDGEVVY
     QRGEK
//
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