ID   Q1GX41_SPHAL            Unreviewed;      1112 AA.
AC   Q1GX41;
DT   27-JUN-2006, integrated into UniProtKB/TrEMBL.
DT   27-JUN-2006, sequence version 1.
DT   27-MAR-2024, entry version 111.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   OrderedLocusNames=Sala_0055 {ECO:0000313|EMBL:ABF51781.1};
OS   Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256)
OS   (Sphingomonas alaskensis).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingopyxis.
OX   NCBI_TaxID=317655 {ECO:0000313|EMBL:ABF51781.1, ECO:0000313|Proteomes:UP000006578};
RN   [1] {ECO:0000313|EMBL:ABF51781.1, ECO:0000313|Proteomes:UP000006578}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 13593 / LMG 18877 / RB2256
RC   {ECO:0000313|Proteomes:UP000006578};
RX   PubMed=19805210; DOI=10.1073/pnas.0903507106;
RA   Lauro F.M., McDougald D., Thomas T., Williams T.J., Egan S., Rice S.,
RA   DeMaere M.Z., Ting L., Ertan H., Johnson J., Ferriera S., Lapidus A.,
RA   Anderson I., Kyrpides N., Munk A.C., Detter C., Han C.S., Brown M.V.,
RA   Robb F.T., Kjelleberg S., Cavicchioli R.;
RT   "The genomic basis of trophic strategy in marine bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:15527-15533(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|ARBA:ARBA00009922}.
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DR   EMBL; CP000356; ABF51781.1; -; Genomic_DNA.
DR   RefSeq; WP_011540396.1; NC_008048.1.
DR   AlphaFoldDB; Q1GX41; -.
DR   STRING; 317655.Sala_0055; -.
DR   KEGG; sal:Sala_0055; -.
DR   eggNOG; COG0210; Bacteria.
DR   eggNOG; COG2856; Bacteria.
DR   HOGENOM; CLU_008930_0_0_5; -.
DR   Proteomes; UP000006578; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 1.10.10.2910; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR010359; IrrE_HExxH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF06114; Peptidase_M78; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000006578}.
FT   DOMAIN          188..487
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          488..769
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   BINDING         209..216
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1112 AA;  119274 MW;  BF36ADF2691587FB CRC64;
     MAAFDLARLH ARALREAKIA GRATGPAAVK SAAAAEGFVI KPVPPGDPVI GTSDAKLLRE
     WCSIYVRNDV SDAEAAAFVA HELGHLKLHR PQDNCTGPNP DAGTSRALSR VEAYGPRERR
     ELQANVFARE LLLPRALARQ LFLVERLGAG SIAQLLELPV PLVRRQLFDS LLGPDASAPT
     VNAQKPKFGR DDSQEAAAGF ADPALLLEAG PGSGKTRTLV KRIEHLLDFD EAVPNEILAL
     TFSNKAAGEL ADRIATARPD AAADMWIGTF HAFGLDLIRR YYELLDLPSN VQLIDKAQAI
     ELLEDQLPLM GLNHYHDLRN PDQGLVKILS AISRAKDELV THAEFTRRAR EALAAAVSAE
     QVEVAERACE AARVYEIYAD ALGKAGAVDF GDLVMLPTLL MMRNDCVRAQ VAQRHSMVLV
     DEYQDVNRAS ARLLMELYRE GARLWVVGDA RQSLYRWRGA SSANMAQFER DFSGGKRLPL
     DRNYRSTEHI VGLGRGFARD MRAGKNGLAY NAKSAREEPG SATRLLVGLD DRCEGELLAA
     EITSLKQAGV PLSQQAVLAP TNNRLDIVAG ILAEHGIATT HLGSFFEREE VRDLLSVIAL
     LAEANGGALV RVAALREIGV GASDIGVIVR AAQAARVPLL SLLATASTLT GMSPTGGEAL
     EQLGLQMAGL DQFTPAFEVA ASWLLDRSDY LRDLAVAPDA SGSLSRAALL ALLGFLDQRE
     LGGQPLTPAR ALKRMRSTVL LADDRDLRDA TLGADADAVR LMTIHGAKGL EFPAVHVVGL
     HDQCLPGAFR RDDSPLPPGL VEPETREGHL EEEECLFFVA ISRAEDHLRL YHSELANVRG
     RKPSPFLGRL GALERRHLPA AATAAGAAGS PLSPISTDRI NLFDVRDFDS CPLRIAYRRF
     FGVEGRRHET PYLKTSGVLY ALVDRITEVS GPGVEERLQV LLGEIWAIRG PAEHGLAADY
     LAHAAGRAAA LGRLMSGFDS PGYSQIELPI NGGLLTVAAP LVRSTAAGTE IRFLEAGRVR
     SKTGNDLTAG LLLAAARHTF GPNVSVTIGH VTDGATVPVK RQDDKAAGDV EAAAAILAAI
     NKGALPAKPA MRVCGRCPHF VACPAVGRAE TA
//