ID Q1HMC6_ECOLX Unreviewed; 217 AA.
AC Q1HMC6;
DT 13-JUN-2006, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2006, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Gcl {ECO:0000313|EMBL:ABF20181.1};
DE Flags: Fragment;
GN Name=gcl {ECO:0000313|EMBL:ABF20181.1};
OS Escherichia coli.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562 {ECO:0000313|EMBL:ABF20181.1};
RN [1] {ECO:0000313|EMBL:ABF20181.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=00-5288 {ECO:0000313|EMBL:ABF20180.1}, and 99-4389
RC {ECO:0000313|EMBL:ABF20181.1};
RX PubMed=17446284; DOI=10.1099/jmm.0.47053-0;
RA Gilmour M.W., Olson A.B., Andrysiak A.K., Ng L.K., Chui L.;
RT "Sequence-based typing of genetic targets encoded outside of the O-antigen
RT gene cluster is indicative of Shiga toxin-producing Escherichia coli
RT serogroup lineages.";
RL J. Med. Microbiol. 56:620-628(2007).
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQ472539; ABF20180.1; -; Genomic_DNA.
DR EMBL; DQ472540; ABF20181.1; -; Genomic_DNA.
DR AlphaFoldDB; Q1HMC6; -.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR045229; TPP_enz.
DR PANTHER; PTHR18968:SF14; GLYOXYLATE CARBOLIGASE; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
PE 3: Inferred from homology;
FT DOMAIN 22..156
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABF20181.1"
FT NON_TER 217
FT /evidence="ECO:0000313|EMBL:ABF20181.1"
SQ SEQUENCE 217 AA; 24042 MW; A3CBA88F880D848D CRC64;
EFDPDMYEPL PVYKPAASRM QIEKAVEMLI QAKRPVIVAG GGVINADAAA LLQQFAELTS
VPVIPTLMGW GCIPDDHELM AGMVGLQTAH RYGNATLLAS DMVFGIGNRF ANRHTGSVEK
YTEGRKIVHI DIEPTQIGRV LCPDLGIVSD AKAALTLLVE VAQEMQKAGR LPCRKEWVAD
CQQRKRTLLR KTHFDNVPVK PQRVYEEMNK AFGRDVC
//
