ID Q1I965_PSEE4 Unreviewed; 384 AA.
AC Q1I965;
DT 13-JUN-2006, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2006, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Macrolide efflux protein MacA {ECO:0000313|EMBL:CAK15813.1};
GN Name=macA {ECO:0000313|EMBL:CAK15813.1};
GN OrderedLocusNames=PSEEN3043 {ECO:0000313|EMBL:CAK15813.1};
OS Pseudomonas entomophila (strain L48).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=384676 {ECO:0000313|EMBL:CAK15813.1, ECO:0000313|Proteomes:UP000000658};
RN [1] {ECO:0000313|EMBL:CAK15813.1, ECO:0000313|Proteomes:UP000000658}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=L48 {ECO:0000313|EMBL:CAK15813.1,
RC ECO:0000313|Proteomes:UP000000658};
RX PubMed=16699499; DOI=10.1038/nbt1212;
RA Vodovar N., Vallenet D., Cruveiller S., Rouy Z., Barbe V., Acosta C.,
RA Cattolico L., Jubin C., Lajus A., Segurens B., Vacherie B., Wincker P.,
RA Weissenbach J., Lemaitre B., Medigue C., Boccard F.;
RT "Complete genome sequence of the entomopathogenic and metabolically
RT versatile soil bacterium Pseudomonas entomophila.";
RL Nat. Biotechnol. 24:673-679(2006).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CT573326; CAK15813.1; -; Genomic_DNA.
DR RefSeq; WP_011534201.1; NC_008027.1.
DR AlphaFoldDB; Q1I965; -.
DR STRING; 384676.PSEEN3043; -.
DR GeneID; 32806157; -.
DR KEGG; pen:PSEEN3043; -.
DR eggNOG; COG0845; Bacteria.
DR HOGENOM; CLU_018816_14_1_6; -.
DR OrthoDB; 9791520at2; -.
DR Proteomes; UP000000658; Chromosome.
DR GO; GO:0019898; C:extrinsic component of membrane; IEA:InterPro.
DR GO; GO:1990195; C:macrolide transmembrane transporter complex; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 6.10.140.1990; -; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR030190; MacA_alpha-hairpin_sf.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469:SF33; EFFLUX PROTEIN; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..384
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004190792"
FT DOMAIN 58..246
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT COILED 100..165
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 384 AA; 41614 MW; 7AF8B3568F0AC46C CRC64;
MEKSKFRKIT LGAAAALVAG IVLYAVQAPA KPPQYITATV ERGDIENAVL ATGTLEGIRQ
VDVGAQVSGQ LKSLKVKLGD KVTEGQWLAE IDPLVLRNTL RQAEVDAEKL QAERRSTQAK
LKQAKRVYER YEVLQEDESI SRQDFDNAES EYEVQQANLL SLDAQIKSAQ VQVDTARVNL
GYTRIVAPIN GHVVGVVTQE GQTVIANQLA PILLKLADLD TMTIKAQVSE ADVIHISPGQ
QVYFTILGDD QRYYAKLRGT EPAPQNYLES SDKSSGASRQ ASAVFYNALF EVPNPEHRLR
ISMTAQVRIV LDTAQGVLTV PVAALGARDK DGSFAVRVLD AKGFAQVRKV QAGINNNVKV
QVKAGLDEGD RVVIGEPVTG ESGA
//
